New #JITC review: "Cancer-associated fibroblast targeting therapies as a tool to enhance responses to radiotherapy and immunotherapy" https://t.co/ENwjakAr4h
🚨 New publication alert in @Cancer_Cell from @gunderlab & team!
Their study revealed that #myofibroblast programming (the most common fibroblast phenotype in #pancreatic_cancers) transcriptionally represses differentiation into fibroblastic reticular subtypes that are necessary to form #tertiary_lymphoid_structures in #tumors.
Blocking these myofibroblast differentiation signals combined with agonizing lymphotoxin beta receptor reverses this, thereby inducing TLS and promoting anti-tumor immunity.
🧠These findings help us understand how to overcome resistance to TLS formation order to increase response to #immunotherapy.
Congratulations to the team!
Read More: https://t.co/2ytpJvdyMI
@OhioStateSurg@OhioStatePIIO
A remarkable 7th Annual #PIIO Symposium — four sessions of cutting-edge IO science, new ideas, and powerful collaboration.
We wrap with our Awards Session, recognizing excellence in poster presentations and discovery across PIIO. The future of #immuno_oncology is bright. @OSUCCC_James@Zihai@Pelotonia
Impressive talk by @gunderlab highlighting how tertiary lymphoid structures may unlock new therapeutic paths to overcome immunotherapy resistance in #PDAC. @OhioStatePIIO annual symposium 2025
👏 Big congratulations to this year’s award winners at The @OSUCCC_James Annual Scientific Meeting — proud to see #PIIO scientists among the honorees! 💪 #ImmunoOncology#CancerResearch w/Monica Venere, PhD; Gaurav Shrestha PhD; Raven Vella; Elijah @kirschstein13
Gunderlab with a great showing at PancMidwest at "TSUN" 😉, and @OSUCCC_James annual scientific meeting. Congrats to @kirschstein13 for winning the top travel award and for Maddie's first poster on B cells in PDAC. Labby hour and eucher to celebrate @OhioStatePIIO@OhioStateSurg
Hard to have a better first conference experience for @kirschstein13. Awesome job on your talk and congratulations on your young investigator award! @NIH funded research on reprogramming stroma to enhance immune responses in PDAC patients. @OhioStatePIIO@OhioStateSurg
Congratulations @kirschstein13, 2nd year BSGP grad student, who was "dialed" for his poster award at the 2024 @OhioStatePIIO symposium, 👏. Big plans for gunderlab in 2025! @OhioStateSurg
At halftime, recipients of the #mshsl Triple A award are honored. They are seniors from around the state who excel in Academics, Arts and Athletics. Congratulations!
Mr. Basketball announces its Top 10 list of candidates for the 2019 award. Look for the Final Five to be announced in early March.
https://t.co/qj8C76zbtX