Korede_Sugarrrr

I’m here because of peer pressure.

[يوسف @the_mayyowa]

I think one thing I wasn’t prepared for in my adulthood is how casually dishonest humans are.

People lie for no reason. Even in situations where it is unwarranted. They just tell lies anyhow.

Dishonesty is so normalised that you seem odd when you frown upon it.

Wild stuff.

[Baby Mars |framer developer🍂 @tearsandguile]

I built the Nigerian Literature Archive for the books many of us grew up reading and the ones we may have forgotten.

From Ige Adubi to Ralia the Sugar Girl, Eze Goes to School and more, it’s a small way to preserve and rediscover Nigerian literature.

https://t.co/c1PJNqpXeL

[babe of astounding weight™️ @AsChiWasSayin]

the insult no move me

[Manzi @ClixWell]

“A way forward.”

[kelvin @kelvinholdon]

Omo to give up sweet ooo
I just dey rest since morning

[akosua @akosuaachiaa__]

everyday i thank God for removing me from the dating market because you people are dealing with principalities

[The REAL Suburban Mom @ItsMrsPlugg]

We broke up after 9 years. A year later we realized there was NOTHING out there that came close to what we meant to each other (all bs included) we got back together and got married a year after that, life has been perfect ever since 😭

[Bryan Johnson @bryan_johnson]

🚨Kate officially diagnosed with endometriosis

> done without surgery
> across three modalities: imaging, blood, and AI
> all non-invasive
> in 42 days

For context, average time to diagnosis is 6.6 years.

And, we found 2 other diagnoses at the same time.

Over the past 6 weeks, we’ve sprinted to confirm or deny Kate’s suspected endometriosis. Endo is notoriously challenging to diagnose.

It’s one of the most gnarly diseases and affects 15% of women.

Men, to get you on the same page, having endo is akin to an alien growing in your guts and balls, self replicating, and glueing everything together. Causing you constant pain and discomfort.

We got to work.

> got an MRI
> got a transvaginal ultrasound
> both results came back negative

At this point, Kate’s patient journey had followed the archetype precisely. Most women don’t get diagnosed for 7-10 years. For Kate, it’s been 7 years. And, like most women, her imaging came back clear even though now we know that she has endo.

This is why diagnosis has traditionally happened via surgery. There has been no other way than to open her up and look inside.

We wanted to avoid surgery so we went back to the drawing board. We searched the world over.

On our second go, we did:

> endo-specific ultrasound
> an endo blood test
> AI MRI
> saliva test

This was successful.

We were able to confirm her endo via ultrasound, blood test, and MRI. Confirmed simultaneously by three unique modalities, as far as we know, a world-first approach.

The extensive measurement allowed us to find additional things.

Her ultrasound showed:

> endometriosis
> PMOS (formerly PCOS) (needs confirmation)
> adenomyosis

30-40% of women have at least one of these conditions. That’s intimidating especially when the path to diagnosis is fraught with so many challenges.

Phase I was getting a diagnosis.

Phase II is curing endometriosis. We’ve already started working.

If you’re a female with suspected endo, here’s what you can do to accelerate your diagnosis.

—
1. Endo-Specific Ultrasound

You want an endo-specific ultrasound. As we saw with Kate, a standard pelvic/transvaginal ultrasound failed to identify her endo.

You want the ultrasound to be performed by a physician or sonographer specifically trained. They follow a special protocol to hunt for endometriosis by mapping the ovaries and uterus, and testing whether organs can slide freely, or are tethered by endometriosis lesions.

It’s best timed just after ovulation, when a small amount of peritoneal fluid aids visualization.

It can detect superficial endometriosis, lesions, and adenomyosis that general imaging misses.

We went to Dr. Kacey Hamilton at Cedar Sinai.

2. AI MRI / MatricesAI

Radiologists miss lesions in up to 60% of cases. We worked with @MatricesAI which leverages AI and a unique dataset to detect endometriosis lesions on pelvic MRI. This model is still new, its first pilot study with 200 participants began in April this year.

Here is how you can work with them:

They’re opening their diagnosis program at the Geneviève Institute to give early access to their AI model in a clinical trial.

They will take you through a state-of-the-art clinical intake questionnaire. Help you advocate for your symptoms with your gynecologist, based on your intake or connect you to a new center where their AI is being piloted and the clinical trial conducted.

3. Blood test / HerResolve

Kate had two small tubes of blood drawn for a test built by @Heranovalifesci.

The test measures seven biological markers (three microRNAs, three proteins, and one hormone) and uses an AI model to help detect endo.

It was highly accurate in its validation study at confirming endo and caught most cases that ultrasound and MRI had missed.

Their technology has been validated in a peer reviewed study (298 women, 11 sites across US/Europe/Hong Kong, published in the Journal of Minimally Invasive Gynecology): specificity 97.5%, sensitivity 80%, with strong diagnostic performance (94.4%), demonstrating it was highly effective at distinguishing women with endometriosis from those without the disease.

A positive result is a strong signal, since only 2.5% of women without endometriosis test positive, though final confirmation is still clinical. A negative is less conclusive, because the test misses about 20% of true cases.

The test identified 61.5% of histologically confirmed cases that transvaginal ultrasound and/or MRI missed.

#

We did one more saliva based test and will report back on that when results are returned.

[Adedotun Senpai 👨🏾‍💻🎹 @AD_Tonnee]

@SirLeoBDasilva PS: for those looking for technicalities, situationships count too, FWB counts too, relationships of less than a year count too, and a whole lot of “romantic involvements”.

[Bella Hadidn’t @SkinwithLolami]

Occasionally, ask yourself “How am I complicit in creating the conditions I say I don’t want?”

Because it’s so easy to blame other people while avoiding the discomfort of self-reflection.

[Maandamano Hottie 🇵🇸 @_omalicha__]

This is so real. Having a capacity for your life by expanding it (hobbies, work, friends, etc) remediates this.

[Yoriyori-OyokO💕🎀 @Ify__oma]

Me crying over every little thing even though I’m a very wicked person

[HOT LEGS BIBI🙄 @ButterBibi]

If you visit your partner unannounced and they get angry… walai, you’re very very single.

[co-creator with God. 🥼🩺 @MaryRoseMalomo]

“Nnu Ego lay down by the roadside, thinking that she had arrived home. She died quietly there, with no child to hold her hand and no friend to talk to her. She had never really made many friends, so busy had she been building up her joys as a mother.”

I cried.😭

[Palash Shah @palashshah]

what if the guy who invented umbrellas wanted to name them brellas but hesitated

[Andra @BioavailableNd]

One of the coolest fungal findings in the research: brushing your teeth 2-3x vs 1x/day lowered Candida Albicans not just in the mouth… but in stool too. Your oral microbiome and gut microbiome are deeply connected.

[Motolani Alake @OneMotolani]

A human being cheating has little to do with timing, age or anything. Yes, those factors amplify the chances, but a cheater will cheat, regardless of mitigating circumstances or knowledge, because that adrenaline > what’s right.
It’s a character flaw - it doesn’t need triggers.

[Bella Hadidn’t @SkinwithLolami]

“People know exactly what they’re doing”

Until it’s you. Then suddenly, your intentions matter. Everyone wants grace for themselves, but rarely wants to extend it to others.

[BETTY @betty_nft]

I know a lot of people will look at this photo as if it’s unnecessary and over the top but this is the reality of what women have to deal with.

The condition he is talking about is so common, so painful, so invasive and chronic and yet so under-researched or understood. In fact some of the more recent studies on endo focus instead on the effect on the male partners of women with it, all while there is still no cure or any sort of proper acknowledgement for women suffering with it. Women’s health is underfunded, and hasn’t been a priority historically.

Whatever you think about this man, him and his partner will probably end up doing more for women’s health with this study than the last 100 years of research have achieved.

[Demotivational Speaker @OdunEweniyi]

consequences