Shalin Kothari

Husband, Father, Son, Brother, Friend and Assistant Professor @YaleMed with a focus on Lymphoid Malignancies.

[Shalin Kothari @kotharishalin]

Heading to SF this weekend for The Future of Agentic AI in Healthcare hackathon hosted by @AbridgeHQ with @AnthropicAI and @lightspeedvp, in partnership with @cerebral_valley at @SHACK15sf.

As a lymphoma oncologist who builds, the plan: an agent that helps oncologists pick treatments pulling patient context, guidelines, and literature with evidence you can actually see and trust.

If you're going, come find me. Clinician seeking engineer teammate 👨‍⚕️🤝👩‍💻

[Amer Zeidan عامر زيدان @Dr_AmerZeidan]

our great @YaleHematology group after a very educational post #ASH2024 highlights meeting @YaleCancer

[Shalin Kothari @kotharishalin]

@rahulvohra Yes please! I absolutely love the app.

[Shalin Kothari @kotharishalin]

I think most patients should get consecutive therapy, but some with poor risk phenotypes (complex karyotype, TP53 aberration, NOTCH1/2, etc) should get upfront kitchen sink of newer drugs. I hope that the regulators don’t approve these combos in all comers without clear combo vs consequent data! One can hope.

[Shalin Kothari @kotharishalin]

The anxiety of navigating trial eligibility criteria to find 'gotcha' exclusions for patients who could benefit is real. Just had to exclude a patient due to a highly curable cancer from almost 2 years ago. Clinical trials (except for FiH studies) MUST evolve to reflect real-world patients—our research is meaningless without true representation!

[Shalin Kothari @kotharishalin]

Every so often, you meet patients who, despite their suffering, brighten your perspective with meaningful, selfless lives full of volunteerism. This irreplaceable aspect—the honor of knowing them—will never be threatened by the AI-ification of medicine. This is the art of medicine, which by definition, is not artificial.

[Leo Meriranta @Merijellona]

Friends! I am super-excited to share our story on KLHL6 in this @BCD_aacr

📣KLHL6 targets the B-cell receptor and lymphoma mutations perturb this homeostasis!

🔓Read
https://t.co/koCsl1RmCe

🪩Joint editorial in @CD_AACR
https://t.co/Bot04pxxih

🧵Let’s go

[Sam Yamshon @samyamshon]

There is quite literally no better feeling in the world than showing a patient a PET scan that shows a complete remission. Several in one day is an embarrassment of riches. Feeling grateful, and hoping for many more!

[Roni Shouval @RShouval]

Wow! Genetic guidance of treatment in newly diagnosed #DLBCL https://t.co/R9N9KB4VVX

[Shalin Kothari @kotharishalin]

@faizayasin_md and I look forward to discussing this case! MCL can be a perplexing disease to treat with more unknowns than knowns, but that’s changing for the better.

[IACH @TheIACH]

📢Join us for the upcoming IACH Junior Club:
'Mantle cell lymphoma case'
Monday, November 14, 2022
6:00pm Paris, 5:00pm London, 12:00pm NY
Free Registration: https://t.co/9a4FF3iWRW
@Mohty_EBMT @Florent_Malard @kotharishalin @faizayasin_md

[Shalin Kothari @kotharishalin]

A fantastic opportunity to work with a group of talented scientists in this field at Yale! #lymsm

[Müschen Lab @MuschenLab]

Postdoc and postgraduate positions in our lab -genetic engineering of human immune cells and lymphoma in humanized mice. https://t.co/yFwEXk5pLC

[Yale Cancer Center @YaleCancer]

Yale Cancer Center is pleased to announce further investment in our Hematology/Oncology Fellowship Program led by Dr. Alfred Lee with a $1.5 million commitment to the program. @YaleHemOnc @YaleMed @YNHH
Learn more: https://t.co/7ZdSAKPxGI

[Sahil Bloom @SahilBloom]

The most powerful paradoxes of life:

[Houssein Safa, MD @hsafaMD]

Sorry guys but Hematology Oncology is undoubtedly the best specialty out there and I’m not taking no for an answer.

[Vinay Prasad MD MPH @VPrasadMDMPH]

What we will likely regret re US pandemic:
[THREAD]
1. Entire USA shut down hard in early March (for many places this was excessive, 4 others came too late, NYC).

Use of restrictions at wrong time depletes the populations energy & cannot be sustained....

[Shalin Kothari @kotharishalin]

@graham74GC @AaronGoodman33 My lymphoma clinic yesterday!- blastoid MCL on EA4151, WM - 2nd line, PLL- 4th line w/ massive spleen, R/R Burkitt in a young guy, R/R MCL on a BTKi+IRAK4i trial x2, pleomorphic MCL in a nonagenerian man, CLL on w/w x2, double hit DLBCL, R/R MCL on BTKi,cutaneous BCL in remission

[Shalin Kothari @kotharishalin]

@PallawiTorkaMD @SoniSmithMD @JohnPLeonardMD @michaelwangmd I would rechallenge with 1 gm/m2 after complete resolution. Not sure if deoxycytidine eye drops (have never used it myself) are available. If not, I would combine diclofenac drops with dex drops for upcoming cycles. May also consider going up to 1.5 g/m2 if next cycle uneventful.

[John P. Leonard, MD @JohnPLeonardMD]

A lymphoma version of "scientific papers" with apologies to and acknowledgment of
@xkcdComic