Müschen Lab

B-cell dynamics, oncogenic signaling in B-cell malignancies @YaleUniversity. Since January 2026 @muschenlab.bsky.social

[Science Signaling @scisignal]

A signaling loop centering on the protein CD25 sustains the growth of acute leukemias such as #AML and #B-ALL by fine-tuning the activity of oncogenic tyrosine kinases, according to a new study. @MuschenLab @Yale https://t.co/bFneMnb3xB

[Müschen Lab @MuschenLab]

Yale Study Identifies a New Class of Drug Targets for Aggressive Leukemia https://t.co/URpJdAgrCD

[Müschen Lab @MuschenLab]

On this week's cover of Science Signaling. Congratulations to Ruifeng Sun and Jaewoong Lee, who led this effort! Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia | Science Signaling https://t.co/dfK08WqE5y

[Müschen Lab @MuschenLab]

EACR - Overactivation of Oncogenic Signalling as a Potential Cancer Treatment Strategy - ecancer https://t.co/syIISjVsg9

[Müschen Lab @MuschenLab]

Beta-catenin promotes cancer cell growth but B-cell leukemia cells, unexpectedly, depend on its efficient degradation. Our paper out today in @naturecancer, shows how this dependency could be leveraged for the benefit of patients with B-ALL.👇 https://t.co/xELfFYXGx3

[Müschen Lab @MuschenLab]

👇In a few weeks, the Samir Zaidi Lab will open at Yale. Exciting and important science and a generous and supportive mentor - phenomenal opportunity for future graduate students and postdocs with an interest in lineage plasticity and drug resistance in cancer.

[Samir Zaidi, MD, PhD @samirzaidi]

Fifteen years ago, my wife, Salimah, and I met as graduate students at @Yale in New Haven. Now, in a full-circle moment, I’m thrilled to share that I’ll be joining the @YaleCancer and @ynhhealth to launch my independent lab in March 2025! @samirzaidi

I’ll be based in the Center of Molecular and Cellular Oncology and look forward to collaborating with incredible scientists like @BraunMDPhD, @ishizukalab, @S_J_Aitken, #CarolineMlynarczyk, #FrederickWilson and many others, under the leadership of @MuschenLab.

I’m deeply grateful for the invaluable mentorship at @MSKCancerCenter ––from #CharlesSawyers @SawyersLabMSKCC, #MichaelMorris, @DrRosenbergMSK —who have guided me along this path.

This transition wouldn’t have been possible without the unwavering support and vision of @DrEricWiner. His leadership made Yale feel not just like an exciting scientific home, but a truly warm and welcoming community—one that I can’t wait to be a part of.

Excited to continue seeing patients in my clinic at @YaleCancer, and of course, to introduce our two boys to some legendary New Haven pizza!

[Müschen Lab @MuschenLab]

Welcome back to Yale, Samir. So glad to have you joining us!

[Samir Zaidi, MD, PhD @samirzaidi]

Fifteen years ago, my wife, Salimah, and I met as graduate students at @Yale in New Haven. Now, in a full-circle moment, I’m thrilled to share that I’ll be joining the @YaleCancer and @ynhhealth to launch my independent lab in March 2025! @samirzaidi

I’ll be based in the Center of Molecular and Cellular Oncology and look forward to collaborating with incredible scientists like @BraunMDPhD, @ishizukalab, @S_J_Aitken, #CarolineMlynarczyk, #FrederickWilson and many others, under the leadership of @MuschenLab.

I’m deeply grateful for the invaluable mentorship at @MSKCancerCenter ––from #CharlesSawyers @SawyersLabMSKCC, #MichaelMorris, @DrRosenbergMSK —who have guided me along this path.

This transition wouldn’t have been possible without the unwavering support and vision of @DrEricWiner. His leadership made Yale feel not just like an exciting scientific home, but a truly warm and welcoming community—one that I can’t wait to be a part of.

Excited to continue seeing patients in my clinic at @YaleCancer, and of course, to introduce our two boys to some legendary New Haven pizza!

[Yale Cancer Center @YaleCancer]

New research presented at #ASH24 from the @MuschenLab by @RuifengSun2 shows the previously unrecognized role of PKCδ and CD25 in to control BCR signaling in Mature B-Cell #Lymphoma. @YaleMed @OncoAlert @YaleHematology
https://t.co/PDEcaSsuY2

[Yale Cancer Center @YaleCancer]

.@RuifengSun2 presents research @MuschenLab showing CD25 as a regulator of the B pathway and suggesting it as a new therapeutic target for acute lymphoblastic leukemia #ALL at #ASH24. @YaleHematology @OncoAlert @YaleMed @YaleIBIO https://t.co/2KlOc5XoyL

[Yale Cancer Center @YaleCancer]

Zhangliang Cheng @MuschenLab presents on the 3 stages of B Cells and oscillations between MYC and BCL6 dependent states in B Cell #lymphoma. #ASH24 @YaleMed @SmilowCancer

[Müschen Lab @MuschenLab]

Congratulations, both of you!

[Brian Liau @brian_b_liau]

We all have our scientific role models. I’m so lucky that mine was my own mom. 1st-generation & running a lab while raising two boys, she overcame many barriers, to say the least. After 45 years of discoveries @MIT, I hope you enjoy retirement! https://t.co/pRY8Egb6cL

[Sirpa Leppa @LeppaSM]

Leo Meriranta @Merijellona is defending his PhD thesis “molecular cross-section of high/risk #DLBCL” today. It is an honor to chair and enjoyable to listen high level scientific discussion lead by Dr Dan Hodson. Thank you Dan, well done Leo!

[Müschen Lab @MuschenLab]

Congratulations, David!

[Müschen Lab @MuschenLab]

Welcome to Yale!

[Ping Mu 🇺🇦 @PingMu_PhD]

Super excited to share that we’ve moved to Yale University’s Department of Urology to continue our prostate cancer research. Already loving the Yale community and looking forward to some awesome collaborations ahead. @Yale_Urology @YaleMed @YaleCancer @Yale

[Müschen Lab @MuschenLab]

Wonderful to be hosting Michael Reth @theNASciences , who discovered the ITAM and pioneer in immune receptor signaling. Thank you for an inspirational seminar @YaleIBIO and private brainstorming session over breakfast.

[Siyuan (Steven) Wang @SStevenWang]

The ‘China Initiative’ failed US research and national security. Don’t bring it back.  https://t.co/B1i3ugQqCw

[Steven Banik @StevenMBanik]

Excited our final version of @tineisadora's work on targeted protein relocalization is out today @nature! Molecular control over protein localization could offer new opportunities for therapeutics and biological discovery. @Stanford_ChEMH @StanfordUChem https://t.co/XQFwRmnfaX

[Müschen Lab @MuschenLab]

@KevinWNg Very cute picture of Clovis. I admire how he is always happy and with shining fur (I think biomarker of dog happiness), not a small feat in Manhattan. Our basset hound passed away a few years ago, hoping to not be dogless for much longer.

[Müschen Lab @MuschenLab]

@LindaCPhD This is what I learned from Christian: small grants add up and we should appreciate them. I am glad to see that both of us are following Christian's philosophy!

[Müschen Lab @MuschenLab]

Congratulations, Linda!

[Lai (Linda) Chan @LindaCPhD]

Received an NOA for a small foundation grant 💰 today. Feeling very excited and grateful. 😊 #NewPI #AcademicChatter #AcademicTwitter

[Müschen Lab @MuschenLab]

Congratulations, Uli, taking PU.1 research to a whole new level.

[Uli Steidl @SteidlUli]

Very happy and proud to see this study on PU.1 transcription factor "redistribution" and its mechanistic implications out in @NatureGenet today. Huge congrats to lead author @SamuelJohnTayl1! (recruiters watch out: Sam is on the faculty job market now...!). A big thank you also to the entire collaborative team including the twitterless Gregory Poon and Kristy Stengel! @EinsteinCellBio @Einstein_SCI @EinsteinMed