Katie Guzzetta 🌻

All things #Microbiota! 👩‍🔬💩 Formerly @HamiltonCollege🇺🇲 ➜ @Pharmabiotic🇮🇪 ➜ @harvardmed 🇺🇸➜ @ETH🇨🇭

[Cell Host & Microbe @cellhostmicrobe]

Microbial IAM alleviates PCOS

C. aerofaciens & metabolite indole-3-acetamide (IAM) mitigate polycystic ovary syndrome pathology via activating adipose HIF-2α-ceramide signaling. Probiotic strain producing IAM shows therapeutic efficacy in mouse PCOS model
https://t.co/aEg0DmD7ez

[Eric Topol @EricTopol]

Our understanding for how our brain ages and why our memory slips after age 50 have been completely revamped through 2 new landmark studies of the microglia, the brain immune cells

[Katie Guzzetta 🌻 @ktguzz]

Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance
#PeanutAllergy #GutMicrobiome #FMT https://t.co/UJn4NeMJJh

[Boushra Dalile, PhD @BDalile]

New paper out! 👇

[UCCpsychiatry @UCCpsychiatry]

Maternal gut microbiota disruption alters postpartum maternal behavior in association with modulation of stress responses and brain tryptophan metabolism in mice https://t.co/fJD0lWEuQM

[Cell Host & Microbe @cellhostmicrobe]

Universal microbiome signature for CRC

Large gut microbiome meta-analysis of colorectal cancer uncovers CRC microbiome signatures universal across ages & sequencing methods & modifiable by dietary interventions, i.e. fiber.
https://t.co/KlhTm7rqRo

[Cell Host & Microbe @cellhostmicrobe]

Weekend read! Microbiota extends reproductive lifespan

Germ-free female mice undergo accelerated primordial follicle loss & reduced reproductive capacity that are restored upon post-natal colonization. Microbial SCFAs & fiber mitigates ovarian dysfunction
https://t.co/cAMSoZrI2U

[Katie Guzzetta 🌻 @ktguzz]

#Microbiota from young mice restore the function of aged ISCs.
@GutMicrobiome #aging https://t.co/lamsSdxlhw

[Katie Guzzetta 🌻 @ktguzz]

#GutMicrobiota transfer from old mice accelerates aging in adults
https://t.co/9ofBjjj1nW

[Microbiome Research Reports @MicroResRep]

Excited to share a new #Commentary by Marco Ventura, a leading figure in the field of #Bifidobacterium research:
“Mapping the #genomic landscape of two key human #gutmicrobial species: Bifidobacterium infantis and Bifidobacterium longum”
Read👉https://t.co/HrGkSJpZAu
#Microbiome

[Katie Guzzetta 🌻 @ktguzz]

Adolescent obesity induces sex-specific alterations of action control
https://t.co/Dn3IQIvYQp

[Satchin Panda @SatchinPanda]

We analyzed 2.6M food & beverage logs from ~20,000 people to uncover (among other insights) what’s consumed every 2 hours across a 24h day.
Some usual suspects… and a few surprises.
Take a guess—then check the list 👇
https://t.co/ifqEyMnIEp
@NatMetabolism

[Cell Host & Microbe @cellhostmicrobe]

Not just passengers!
Perspective by Colin Hill & Co examines role of phages in fecal microbiota transplants (FMTs). Phages may actively reshape the recipient’s gut by transferring genes between microbes, potentially influencing treatment success
https://t.co/PeYd1haayT

[Katie Guzzetta 🌻 @ktguzz]

@svetlana_up It will be held only in person with a strong emphasis on networking and interactions 🙂

[Katie Guzzetta 🌻 @ktguzz]

Two more days until the 2nd edition of our Swiss-wide #microbiome & health event! 🇨🇭🦠

We've got a brilliant lineup of speakers and I'm excited to once again moderate the panel discussion. Make sure to register for free at
https://t.co/Nlr8XwPlr0

[Nutrition Science @NutrioSci]

Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis

@NatMetabolism @E_MSchneider @jfcryan

https://t.co/GAJcudBGH3

[Prof. Akiko Iwasaki @VirusesImmunity]

Our new preprint by @peowenlu @SaefIzzy @weinerlabhms and colleagues shows that nasal anti-CD3 monoclonal antibody treatment can reduce neuroinflammation in a mouse model of Long COVID, even when administered at 4 weeks after infection 🧠
https://t.co/P8FZA2XA37

[Nature Reviews Gastroenterology & Hepatology @NatRevGastroHep]

New online! The microbiome regulates host metabolic health and diseases through microbial enzymes https://t.co/n4OB3FhxS6

[Katie Guzzetta 🌻 @ktguzz]

@simyersin Congratulations to @simyersin and team for their newest publication!

"Strain-level translocation and enrichment dynamics of oral #bacteria in the lower gastrointestinal tract of stunted children"

https://t.co/M78EAFQl3K

[GI Nutrition Foundation @GI_NutritionFdn]

If people with #celiacdisease lack the microbes needed to break down certain fibers, they don't benefit from consuming them

@VerduLab, @AlbertoCaminer7 & colleagues found patients with #celiacdisease had impaired microbial fiber metabolism in the small intestine, which was associated with depletion of the fiber-degrading taxa:

✅ Findings align with @DrHArmstrong research on β-fructan fibers' role in inducing inflammation if the microbes needed to ferment the fiber are not present

✅ While a high fiber intake is often recommended to newly diagnosed patients with celiac disease alongside the gluten-free diet to improve constipation, these findings suggest that it's first important to restore the gut ecosystem

✅ In mice, an inulin-supplemented diet increased small intestinal short-chain fatty acids and could be used as adjuvant therapy for the gluten-free diet to promote mucosal healing, when metabolizing taxa are present

📚 Read more: https://t.co/SJiMhPvqB0