In 2021, scientists strapped wrist trackers on 88,026 adults and watched when they fell asleep for nearly six years. The bedtime with the lowest heart disease risk was 10 to 11 PM. Going to bed past midnight raised heart disease risk by 25%, and falling asleep before 10 PM was almost as bad at 24% higher. The numbers held even after they adjusted for total sleep duration, smoking, weight, and cholesterol.
The reason only got figured out in the last 15 years. In 2012, scientists found the brain has its own overnight cleaning crew, called the glymphatic system. While you sleep deeply, it washes out the day's waste. Part of that waste is amyloid beta and tau, the same gunk that builds up in the brains of people with Alzheimer's.
Miss a night and the cleaning stops. In 2018, a team at the NIH made 20 healthy people stay up all night, then scanned their brains the next morning. The amyloid had visibly risen. From one bad night. In 2026, a bigger study with 39 people in Nature Communications confirmed the same clearance system in healthy humans.
The metabolic hit shows up just as fast. Back in 1999, researchers at the University of Chicago put 11 healthy young men on 4 hours of sleep for six straight nights. Their bodies stopped handling sugar the way they should, in a range that looked like early diabetes. Their insulin response dropped about a third. These were 20-something guys in great shape.
The population-level numbers are uglier. RAND put the US cost of bad sleep at $411 billion a year, around 2% of the entire economy. People sleeping under 6 hours die 13% more often than people sleeping 7 to 9 hours. AAA found that close to 1 in 5 deadly US crashes between 2017 and 2021 involved a sleepy driver. Roughly 6,400 deaths a year. People die because somebody else stayed up too late.
And then there's alcohol. Stay awake for 17 hours, and your reaction time matches someone at 0.05% blood alcohol, the legal driving limit in most of Europe. At 24 hours awake, you match 0.10%, above the US drunk-driving limit. The CDC has been publishing this for 20 years. People who would never drive after two drinks regularly drive after 17 hours awake.
So Bryan's one-line tweet is backed by 25 years of medical research that all says the same thing. The actual window is 10 to 11 PM.
I carry a gene that raises my risk of Alzheimer's by 40%.
It is called APOE ε4. About 25% of people carry at least one copy. I have one. My son David has the same one.
Nobody told me until I was 53. After my heart attack. After 12 years of annual physicals.
The test costs $100. Once. For life.
Can finally talk about the recent 11,000+ Epstein file leak by the DOJ, what happened, and where you can get view the files yourself.
https://t.co/RzBn8mJVED
Gacha is launching the ultimate onchain super app on @AbstractChain - the consumer chain ✳️
Making crypto fun, simple, and accessible for everyone, everywhere.
Receive early access below 👇
Why I consume extra virgin olive oil and macadamia nuts: they function as natural Ozempic.
Mono-unsaturated fatty acids (MUFAs) are abundant in extra virgin olive oil (EVOO), macadamia nuts, and avocados.
High intake of mono-unsaturated fatty acids (MUFAs) is associated with a 6% reduction in all cause mortality risk, compared to an 8% increase for high intake of saturated fats.
Replacing saturated fats (5% of total calorie intake) with MUFAs was associated with a 15%, 10%, and 11% decrease in all-cause, heart disease, and cancer mortality risk.
MUFAs including oleic acid in olive oil and palmitoleic acid in macadamia nuts, have plenty of observational and interventional clinical evidence supporting their roles in promoting longevity and preventing age-related diseases.
A landmark interventional trial showed that regular consumption of MUFAs with a mediterranean diet lowered the risk of cardiovascular disease by 31% or 28%, for extra virgin olive oil (containing MUFAs as oleic acid) and Nuts (Mix of MUFAs and PUFAs), respectively.
Macadamia nuts and extra virgin olive oil are both longevity nutrients that mitigate the risk factors and lower the risk of multiple age related diseases, they also function as natural Ozempic to help maintaining optimal weight and metabolism.
The biggest altseason in history is just about to start!
The key to 1000x is catching the right narrative early
AI agents will lead the 2024-2025 cycle
100$ in the right AI Agents low caps = $100k in 2025
Here are 10 AI agents low-caps with 100-1000x upside🧵👇
3 Solana Airdrops you can't miss out on
Sanctum, Switchboard & Clone
Not much eyes on the last two, and they will catch eyes one way or other
◽️ Sanctum
Said to be the next Jito, Sanctum launched it's points system called "Wonderland"
You can earn EXPs by Holding LSTs and through Pets, Multipliers, Referrals & Quests
To get started, Just go to https://t.co/3sXkKDkCpC (Code : K3YLJC)
Trade SOL to get INF & you'll get the infinitie Pet
You earn 10 EXP per minute for every LST you hold worth of 1 SOL & the Pet will level up
Get at least 0.1 of every LST and own all the Pets
You can complete Quest #2 for the multiplier, the answer is "EVENSTAR CATHEDRAL"
Shill your own Referral below 👇
◽️ Switchboard
The new Pyth, Switchboard raised $3.5M & is very easy to farm
Just use Switchboard powered Price feeds & Earn Orbs
This also gives you some 2-in-1 farming opportunities
The best is literally farming Sanctum as it use Switchboard as it's price oracle
You can also deposit your LSTs to margin, as it also use Switchboard
https://t.co/DZhod4Dnc7
◽️ Clone
So underfarmed, the Total TVL is currently less than <$3M
Get started - https://t.co/tvqC1obr4p
Swap USDC to any cloned asset & earn points equivalent to your Trade volume
You can currently Provide liquidity in cloned assets to get the 2x Multiplier
With literally just $100 worth of trades, I was ranked <1000
I'll write a detailed post on it later once it matures
_______
Once again, How bad do you really want it, anon? 🙃
I'll always be here even if airdrops literally goes to Zero, will you?
We farm every opportunity till we finally make it & ride into sunset 🫡
A #Cosmos#Airdrop update: $PRYZM
Just a quick reminder, if you have been staking $ATOM, $OSMO, $LUNA, $TIA, $DYM or $INJ with @Pryzm_Zone validator, be sure to register your wallet for the airdrop:
https://t.co/AHetmav0b3
Full guide: https://t.co/lm92tkSl46
Good luck!
Disclaimer:
Don’t invest unless you’re prepared to lose all the money you invest. This is a high-risk investment and you should not expect to be protected if something goes wrong. Take 2 mins to learn more.
Thank you Emmy for showering me with 400 Diamonds and getting me to shamelessly tweet this out. If you've collected Ethereum NFTs, all the way back to 2017, head to https://t.co/kWHnnu6OD9 to claim your taste of Diamonds on the best cross-chain rewards program.
If you are staking $DYM 🥩 take the time to vote 🗳️on the new prop
https://t.co/nfppo6b7wY
Stay active in governance - and sometimes it may payoff with an Airdrop 🪂 eligibility criteria 👀
Proposes adjustments
🔸reducing maximum inflation to 8%
🔸increasing minimum inflation to 2%
🔸decreasing the goal bonded of DYM tokens to 50%.
➡️Governance discussion: https://t.co/6Wk4fsjNIc
Reminder if your validator cast their vote they already voted on your behalf - nothing to do. You can always vote on your own to override the vote of your validator(s).
🔸Airdrops coming to $DYM stakers: https://t.co/ZcDBa7qWYP
🔸Stake $DYM with our Sponsor @EnigmaValidator and be eligible for future Airdrops and support @Airdrops_one and @InterchainInfo
https://t.co/EHt4VRCyfZ 🔸
🫡