EngeLab

The Enge lab pursues projects focusing on clonal evolution, gene regulation and cell interaction in cancer using novel single-cell multiomics methodology.

[EngeLab @lab_enge]

https://t.co/h7x0L9xTYh

Kolbeinsdóttir et al, Principles of subclonal gene dosage across human cancer. doi: https://t.co/wk7kW91YrU

[EngeLab @lab_enge]

New preprint from the lab: how does genetic variation within a tumor shape its phenotype?

Spearheaded by talented PhD student Sólrún Kolbeinsdóttir, we have performed whole genome and mRNA co-sequencing on single cells from many patients across six cancer types.

[EngeLab @lab_enge]

We also describe a class of very weakly subclonal solid tumors (“transient clonality”) with extremely high turnover of large genomic segments. Transient clonality appears in several cancer types, and the copy number turnover has large-scale transcriptional effects.

[Björn Reinius @BReinius]

Excited to have published our work on #SEQURNA, a next-generation RNase inhibitor transforming #scRNAseq & other applications.

➡️Introducing synthetic thermostable RNase inhibitors to single-cell RNA-seq 🚀 🌕
https://t.co/qfCNvXm8Kk

🧵…

[PeterK @KharchenkoLab]

Happy to see our work with Jimmie Ye's lab on coordinated variation of different cell types in healthy and diseased individuals published! At the core of it is the scITD tool for tensor decomposition, rotation and interpretation strategy. Great effort by @J_E_Mitchel et al.!

[EngeLab @lab_enge]

Great to be part of this collaboration with @baryawno and @KharchenkoLab among others!

Joint single-cell WGS/mRNA seq is an important tool to understand evolutionary processes in tumors!

[Karolinska Institutet @karolinskainst]

Transformation of fetal Schwann cell precursors (SCPs) may represent one possible mechanism of tumour initiation in #neuroblastoma with chromosome 17 aberrations as a characteristic element. New KI study published in Molecular Cancer @BioMedCentral. https://t.co/demOQSEwgs

[EngeLab @lab_enge]

My research group at Karolinska Institute in beautiful Stockholm, Sweden are hiring.

We combine basic science and clinically relevant work using novel single-cell methodologies. Both experimentalists and comp. sci welcome!

https://t.co/LUlsI6ptW9

https://t.co/AWb9WR0msY

[EngeLab @lab_enge]

We are hiring postdoctoral scholars for a very interesting project that involves both basic research on cancer evolution, and a chance to develop methods that will help shape the future of precision medicine!

Apply here:
https://t.co/tQqrlEKlPh

https://t.co/lu1kZ6OtGu

[EngeLab @lab_enge]

@AnnaVaharautio @NatureComms Congratulations!

[EngeLab @lab_enge]

@TheCiraLab @IwijnDeVlaminck Very cool! Congratulations!

[Cira Lab @TheCiraLab]

Wrists sore from pipetting? Check out our preprint on “Surface Patterned Omniphobic Tiles (SPOTs): a versatile platform for scalable liquid handling”.
https://t.co/hso6nugEFN

[EngeLab @lab_enge]

@Jeff_Mold @PaoloGallipoli @SepidehSheybani @AlexanderDent6 Yeah those are all very cool! Notably using sc as just another (important) tool rather than “sequence 2M cells and see what sticks”.
The challenge is to move away from a highly controlled model system and still derive knowledge from the experiment.

[EngeLab @lab_enge]

@Jeff_Mold @PaoloGallipoli @SepidehSheybani @AlexanderDent6 Wait, which papers did this? Do you mean PDX/genetic lineage tracing-type approaches?

[EngeLab @lab_enge]

@ozgungokce @NatureComms @AndrovicPeter @MaSchifferer Congratulation! Looks useful.

[EngeLab @lab_enge]

@FelixHorns @sydshaffer Congratulations Felix. Very cool work!

[Element Biosciences @ElemBio]

Introducing a $200 genome on the AVITI™ Sequencing System, available today. We’re driving down costs and redefining what a benchtop sequencer can do. Element empowers labs everywhere to produce their own high-quality data. Read our press release: https://t.co/aC388jmsOa
#jpm2023

[Front Line Genomics @FLGenomics]

At #Fog2023 we’ll be hosting a panel discussion on single-cell analysis with @ADBeggs (@UniBirmingham), Martin Enge (@KarolinskaInst) and Irene Papatheodorou (@EMBLEBI). Find out more on our website: https://t.co/UXY6IEJeL3

#genomics

[Front Line Genomics @FLGenomics]

We are delighted to announce that Martin Enge, Assistant Professor at @KarolinskaInst, will be speaking this January at the Festival of Genomics and Biodata! Find out more on our website: https://t.co/XVi5XSTH3Z

#fog2023

[EngeLab @lab_enge]

@agrossfield @arjunrajlab You can do it in inkscape every time, but workload might be higher