Check out our preprint showing that the turnover of NIX and BNIP3 mitophagy receptors via SCF-FBXL4 ligase keeps mitophagy low.
https://t.co/bQFUjeNUkR
Very (very!!) happy to share our latest publication, "PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy", out today in @NatureComms. 1/n https://t.co/zq4JjjyiC4
Late to the Twitter party, but wanted to highlight this excellent study from @LabPagan that provides fundamental insights into how mitophagy is regulated. An elegant mechanism that puts ubiquitin at the centre stage -this from a pathway that is meant to be ubiquitin independent!
Really nice study from the lab of Julia Pagan showing a central role for the F-box protein FBXL4 in ubiquitation and degradation of mitophagy regulators BNIP3 and NIX. @LabPagan. @UQ_News https://t.co/eGkWWlRmRn
Check out our preprint showing that the turnover of NIX and BNIP3 mitophagy receptors via SCF-FBXL4 ligase keeps mitophagy low.
https://t.co/bQFUjeNUkR
A cell videoed through a microscope. DNA in the nucleus (blue), mitochondria (yellow), and the cytoskeletal protein VASP (purple) are shown.
#CellBiology#microscopy#SciArt
11th Brisbane Cell and Developmental Meeting 22nd April 12-4 pm. Presentations by Dr Sarah Boyle, A/Prof Matt Francois, A/Prof James Hudson and Dr Jana Vukovic. Hosted at TRI and on Zoom. Free post-meeting networking event for Brisbane members. Register at https://t.co/OJCkRNCLmn
Checkout our paper describing DDK’s role in human replication and fork repair. Online now @MolecularCell Many thanks to my coauthors @GelotCam @jallepap @jespervolsen https://t.co/FGpZLDeeIE
A peculiar bacterial enzyme has allowed researchers to achieve what even the popular CRISPR–Cas9 genome-editing system couldn’t manage: targeted changes to the genomes of mitochondria, cells’ crucial energy-producing structures. https://t.co/u5qBYOjYrH
A handful of genetic and structural analyses have identified a key feature of #COVID19 — a protein on its surface — that might explain why it infects human cells so readily. https://t.co/yUzrYrcKfu
News & Views: A process termed ubiquitination mediates the regulated destruction of cellular proteins, thereby preventing disease or infection. Structural data now reveal how a crucial regulator of ubiquitination enzymes coordinates this process. https://t.co/Cfc5B3bclM
A useful review of mitochondrial E3 Ubiquitin Ligase PARKIN: Relationships with other causal proteins in familial #Parkinsons & its substrate-involved mouse models
https://t.co/cltSKIRliX