Julia Pagan Lab

Studying protein degradation at The University of Queensland 🧫🔬

[Julia Pagan Lab @LabPagan]

Check out our preprint showing that the turnover of NIX and BNIP3 mitophagy receptors via SCF-FBXL4 ligase keeps mitophagy low.
https://t.co/bQFUjeNUkR

[Natalie Niemi @nieminm]

Very (very!!) happy to share our latest publication, "PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy", out today in @NatureComms. 1/n https://t.co/zq4JjjyiC4

[Julia Pagan Lab @LabPagan]

First PhD completed in our lab!! We are so proud of you Dr @DienGiang , your hard work has paid off! 👩🏻‍🎓🥳

[Michael Lazarou @LazarouLab]

Late to the Twitter party, but wanted to highlight this excellent study from @LabPagan that provides fundamental insights into how mitophagy is regulated. An elegant mechanism that puts ubiquitin at the centre stage -this from a pathway that is meant to be ubiquitin independent!

[Keri-Lyn Kozul @KeriKozul]

Really, really humbled to have had the opportunity to work closely with @DienGiang on this project! 🧫

Go check out some of the cool things we saw!

[Brett Collins @brettcollins100]

Really nice study from the lab of Julia Pagan showing a central role for the F-box protein FBXL4 in ubiquitation and degradation of mitophagy regulators BNIP3 and NIX. @LabPagan. @UQ_News https://t.co/eGkWWlRmRn

[Julia Pagan Lab @LabPagan]

Sylvie Urbe and Michael Clague's group independently discovered the same mechanism and you can read their preprint too! https://t.co/5wWFolbmPr

[Julia Pagan Lab @LabPagan]

Check out our preprint showing that the turnover of NIX and BNIP3 mitophagy receptors via SCF-FBXL4 ligase keeps mitophagy low.
https://t.co/bQFUjeNUkR

[Julia Pagan Lab @LabPagan]

Many thanks to the amazing first authors @DienGiang + @KeriKozul and our wonderful collaborators including @brettcollins100 @LabParton @paganolab @ZurynLab @LazarouLab @Jones_MJK @_AntonioMarzio Robert Taylor @MitoResearch

[Julia Pagan Lab @LabPagan]

Moving week for our lab!

[Dylan Burnette @MAG2ART]

A cell videoed through a microscope. DNA in the nucleus (blue), mitochondria (yellow), and the cytoskeletal protein VASP (purple) are shown.
#CellBiology #microscopy #SciArt

[Julia Pagan Lab @LabPagan]

Join us for this awesome event!

[ANZSCDB @ANZSCDB]

11th Brisbane Cell and Developmental Meeting 22nd April 12-4 pm. Presentations by Dr Sarah Boyle, A/Prof Matt Francois, A/Prof James Hudson and Dr Jana Vukovic. Hosted at TRI and on Zoom. Free post-meeting networking event for Brisbane members. Register at https://t.co/OJCkRNCLmn

[MJK_Jones @Jones_MJK]

Checkout our paper describing DDK’s role in human replication and fork repair. Online now ⁦@MolecularCell Many thanks to my coauthors ⁦@GelotCam⁩ ⁦@jallepap⁩ ⁦@jespervolsen⁩ https://t.co/FGpZLDeeIE

[Julia Pagan Lab @LabPagan]

Love this one 😂

[Rune Busk Damgaard @rbdamgaard]

We all know it's true #ubiquitin

[Julia Pagan Lab @LabPagan]

A fun lab celebration playing Christmas themed putt putt @VicParkGC!🎄🎅🏼 Scientists and swinging candy canes were an interesting mix...

[Nature Portfolio @NaturePortfolio]

A peculiar bacterial enzyme has allowed researchers to achieve what even the popular CRISPR–Cas9 genome-editing system couldn’t manage: targeted changes to the genomes of mitochondria, cells’ crucial energy-producing structures. https://t.co/u5qBYOjYrH

[New Scientist @newscientist]

Mitochondria, the powerhouses inside cells, have been gene-edited for the first time https://t.co/QaRo0RJ2Jr

[Nature Portfolio @NaturePortfolio]

A handful of genetic and structural analyses have identified a key feature of #COVID19 — a protein on its surface — that might explain why it infects human cells so readily. https://t.co/yUzrYrcKfu

[Nature Portfolio @NaturePortfolio]

News & Views: A process termed ubiquitination mediates the regulated destruction of cellular proteins, thereby preventing disease or infection. Structural data now reveal how a crucial regulator of ubiquitination enzymes coordinates this process. https://t.co/Cfc5B3bclM

[The Science of Parkinson's @ScienceofPD]

A useful review of mitochondrial E3 Ubiquitin Ligase PARKIN: Relationships with other causal proteins in familial #Parkinsons & its substrate-involved mouse models
https://t.co/cltSKIRliX

[Julia Pagan Lab @LabPagan]

Giang for completed her M1 on Friday! We are so proud of her 🥳