Negative symptoms in schizophrenia are not simply the absence of hallucinations or delusions.
They are a distinct symptom domain linked to motivation, reward, emotional expression, social cognition, and goal-directed behaviour.
Here’s the neurobiology that helps explain why they can persist, even when psychosis improves. 🧵👇
🚨 Electroconvulsive therapy (ECT) - the most controversial treatment in Psychiatry
A study of >1 million patients with a depressive disorder re-examined the benefits of ECT.
Here's what you need to know about this landmark paper published this week in @BMJMentalHealth
Running vs. Antidepressant (SSRI) for Depression/Anxiety:
-Similar remission rates (45% vs 43%) over 16 weeks
-Compared to SSRIs, the running group had ⬇️ weight, waist circumference, and blood pressure
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In Medicine, you have to know the ECG, Acid Base, Cardiac Cycle, Diabetes Medications and Dosage, Heart Failure, Physics, Astrology, Spotify
Orthopedics:
It’s a landmark in the history of NASH (MASH)
A positive trial: less fibrosis, less inflammation, lower LDL
Something to celebrate
https://t.co/x0GrR6XrHL
#livertwitter
A patient with diabetes who was taking empagliflozin, an SGLT2 inhibitor, had false positive urine screening tests for ethanol in a room-temperature sample, owing to bacterial fermentation of glucose that yielded ethanol. Read the full correspondence: https://t.co/keZ5P5Aozl
Sebastian Bauer (Poland) - "She Loves Sunflowers"
"I want to be like a sunflower; so that even on the darkest days I will stand tall and find the sunlight."
Multiple studies like this one showed a clear link between higher TMAO levels (caused by gut flora)and elevated risk of heart attack, stroke and death.
Crazy!
PS: Cholesterol is still the king
https://t.co/tKG8jeNSVi
New study: Gut bacteria convert choline from RED MEAT into TMA, which becomes TMAO, a chemical that may cause cardiovascular disease. Berberine, a natural molecule that lowers blood sugar (like metformin does) also inhibits production of TMAO 💪 https://t.co/67IJCJgRUh