Susanna Larsson

Associate Professor of Epidemiology

[Shuai Yuan 袁帅 @Yuan_AS]

Our multi-population GWAS paper on Afib is online now @NatureComms

We identified more genetic loci, population-specific genetic correlations, improved polygenic risk score, and enhanced risk prediction by integrating a PRS and protein score.

https://t.co/WCoZYsqDXJ

[Shuai Yuan 袁帅 @Yuan_AS]

ApoE, excess adiposity, elevated blood pressure, type 2 diabetes, and smoking were identified as risk factors for intracerebral hemorrhage.

Findings from our GWAS & MR paper in @StrokeAHA_ASA @American_Stroke

@LarssonSC @dpsg108 @stevesphd

https://t.co/6a6WLmVTAV

[Stephen Burgess @stevesphd]

New review just dropped at @ehj_ed "MR for cardiovascular diseases: principles and applications": https://t.co/Ev8b7m1zG9. Led by @LarssonSC and supported by @aidanbutty. Comments and feedback welcome!

[Shuai Yuan 袁帅 @Yuan_AS]

Our protein-wide MR analysis reveals many blood proteins in the development of type 2 diabetes and complications. Now online in @CellRepMed

Link 🔗 https://t.co/Nt0ovP78JU

A happy journey of this work with @oldz84 @LarssonSC

[Shuai Yuan 袁帅 @Yuan_AS]

Does #obesity increase the risk of #GIDs?

Check up on our comprehensive MR analysis in @ObesitySociety on birthweight, childhood obesity, and adulthood obesity and body composition in relation to 24 gastrointestinal diseases.

🔗https://t.co/zk8ggrtPki

[Shuai Yuan 袁帅 @Yuan_AS]

Our newly online paper:

Risk of incident cardiovascular disease among patients with gastrointestinal disorder: a prospective cohort study of 330,751 individuals

https://t.co/5rAeqhDHd1

[Dipender Gill @dpsg108]

This is my guy @BarWoolf doing some clever stuff to show how mis-specifying the exposure in drug target MR can cause all kinds of problems! Really nicely supervised by @stevesphd to have created a lovely paper

[Susanna Larsson @LarssonSC]

Our study shows that elite female endurance athletes are at increased risk of atrial fibrillation, published in British Journal of Sports Medicine
@BJSM_BMJ https://t.co/vvEumDhdRg

[Shuai Yuan 袁帅 @Yuan_AS]

High intake of #ultraprocessed #food ➡️➡️➡️ venous #thromboembolism ⚠️⚠️⚠️

>>> A moderate association
>>> Population-based evidence from a cohort study in the UK Biobank study @uk_biobank

@LarssonSC

Full-text 🔗https://t.co/Xll4OsxXsx

[BMJMedicine @BMJMedicine]

#Research suggests that higher plasma #caffeine concentrations may have potential benefits for reducing #adiposity and lowering risk of #Type2Diabetes. Clinical study is needed to investigate the translational potential of these findings. ▶️ https://t.co/ndNMeZihdX

@LarssonSC

[Shuai Yuan 袁帅 @Yuan_AS]

We conduct a multinational study to decipher the causal associations of sleep duration and daytime napping with peripheral artery disease. Now published in #EHJOpen

Thanks for the great support from @_J_chen_ @MGLevin @damrauer @LarssonSC

[Benji Woolf @BarWoolf]

New article out in @BMJMedicine with @LarssonSC and @dpsg108 https://t.co/rZ7nkc8KG3
We use drug target MR to support a protective effect of plasma caffeine levels on diabetes - and find that this is mediated by an effect of caffeine on weight loss.

[Shuai Yuan 袁帅 @Yuan_AS]

Our review on #sarcopenia is online in #Metabolism-Clinical & Experimental now. We summarized the epidemiological features of the disease as well as its risk factors and consequences. Future directions in this field were also highlighted.

@LarssonSC

https://t.co/OKh0ghAT9Z

[Shuai Yuan 袁帅 @Yuan_AS]

Happy to share another work with @_J_chen_ @dpsg108 @stevesphd @LarssonSC published in @DiabetesCareADA

Gastrointestinal Consequences of Type 2 Diabetes Mellitus and Impaired Glycemic Homeostasis: A Mendelian Randomization Study

See the figure for the summary of the study

[Shuai Yuan 袁帅 @Yuan_AS]

A review of recent Mendelian randomisation analysis on diabetes, type 1 and type 2, published in @DiabetologiaJnl

The paper describes future directions, challenges, and opportunities in this field.

Many thanks for the great inputs from @Riudecanyenc and @LarssonSC

[Shuai Yuan 袁帅 @Yuan_AS]

Smoking but not alcohol consumption increases the risk of a wide range of gastroenterological diseases.

Results from our Mendelian randomization analysis published in @eLife

Many thanks for the great support from @_J_chen_ @dpsg108 @stevesphd @LarssonSC

[Shuai Yuan 袁帅 @Yuan_AS]

What are the health benefits and risks of drinking milk? Please find the answers in our new online paper in BMC Medicine @BMCMedicine

MR-PheWAS on milk consumption:
https://t.co/x1xcsUlaAx

@LarssonSC

[Shuai Yuan 袁帅 @Yuan_AS]

Any associations between rheumatoid arthritis and cancer risk? Our new Mendelian randomization paper will tell you the answer. @_J_chen_ @LarssonSC @stevesphd @amymariemason @siddhartha_kar @ArthritisRes

https://t.co/gR4sPiBV0o

[Shuai Yuan 袁帅 @Yuan_AS]

Our meta-analysis and Mendelian randomization analysis suggest potential causal associations of serum #homocysteine and possibly #folate levels with the risk of #NAFLD.

https://t.co/xeoJUkrVIP

@AJCNutrition @_J_chen_ @LarssonSC

[Susanna Larsson @LarssonSC]

Our genome-wide association and Mendelian randomization study of FGF21 reveals causal associations with several clinical factors. Read the full-text article in Metabolism
https://t.co/nsA3BmcPDO