L C

all things tech (& maybe other stuff) || come on, do better! || latina, always

[L C @lcontreras]

@NanouuSymeon Yup. I feel old. I wonder how old is xml. 🤔

[L C @lcontreras]

Friendly reminder

[Harry Spoelstra @HarrySpoelstra]

The neurobiology of long COVID

🔥Very interesting work from @VirusesImmunity et al. in which they review what is understood about the pathobiology of post-acute COVID-19 impact on the CNS and discuss possible neurobiological underpinnings of the cognitive symptoms affecting COVID-19 survivors. They furthermore propose the chief mechanisms that may contribute to this emerging NEUROLOGICAL HEALTH CRISIS!

➡️“Neurocognitive and neuropsychiatric impairments experienced by people with both acute and long COVID (neuro-COVID) have led to decline in quality of life and inability to return to previous levels of occupational function, affecting (at least) tens of millions of people.”
➡️“We highlight a number of possible underlying disease mechanisms that could contribute to CNS dysfunction, including neuroinflammatory effects of distal inflammation, autoimmunity, direct CNS infection, herpesvirus reactivation, neurovascular disease, and hypoxia.”
➡️“What accounts for the persistent nature of cognitive dysfunction in neuro-COVID remains to be fully elucidated.”
➡️“Continuing neuroinflammation could reflect a lasting state change in CNS immune and glial cells that perpetuates neural pathophysiology, ongoing endotheliopathy with microvascular disruption and blood-brain-barrier breakdown, autoimmunity, response to ongoing peripheral inflammation, attributable to latent herpesvirus reactivation, possible persistent reservoirs of SARS-CoV-2 infection outside of the nervous system, or persistent circulating viral-spike protein, or a combination of these possibilities.”
➡️“A deeper mechanistic understanding of the pathophysiology of long COVID in general and neuro-COVID in particular will be required to develop effective therapies to ease the suffering of millions of people affected by the often-debilitating long-term consequences of COVID-19.”

❗Instead of lockdown focus BS, media need to focus on this as cause of many interconnected society problems already visible today!
❗AND AGAIN.......AVOID SARSCOV2!!
https://t.co/32YA02It1Y

[L C @lcontreras]

That feeling you get when you're done with a project and likely never work with the folks in that project again
#webdev

[L C @lcontreras]

@lacountyfair the schedules page isn't working. It's returning a 401 error when you try to change to a different date.

[L C @lcontreras]

@christinelu Omg I hope you are safe!!

[L C @lcontreras]

Pea size hail rn.... Ayyyy

[NWS Los Angeles @NWSLosAngeles]

At 515 pm, a tstm is developing over the San Gabriel Valley extending from Pasadena to Montebello. The storm is nearly stationary and could produce brief heavy downpours with local roadway flooding, gusty winds, small hail, and dangerous cloud-ground lightning. #LAWX #LArain

[L C @lcontreras]

@shanselman @HermanMiller I've had one at work for over 15 years and I bought a used one from a office furniture reseller for home. They're the best.

[L C @lcontreras]

@Timodc Very classy lol

[L C @lcontreras]

Need sun asap

[L C @lcontreras]

@Noahpinion Ohhh. Tell us more

[L C @lcontreras]

Omg. I can't imagine 3 months having that part of the 10 closed, but that's not as bad as the 10 fwy segment that collapsed during the #Northridgequake
That felt like it took forever to fix

[Freeways of Los Angeles @FreewaysLA]

The recent fire under the Santa Monica Fwy (I-10) viaduct was very similar to the 2011 tanker fire under the Pomona Fwy (CA-60) Paramount Blvd OC. That one required replacement of the entire structure, a herculean effort that took three months under an expedited schedule.

[L C @lcontreras]

@SegerstromArts Sorry, but it makes no sense providing a link to the instagram post that contains the link to the event that can't be clicked/tapped on. Just include the direct link in this post.

[L C @lcontreras]

@shanselman Wow web 2.0 is that old. Remember wikis, rss, podcasts, and blog were web 2.0??

[L C @lcontreras]

Great news about helping the unhoused
https://t.co/nMNV0aYvi0

[L C @lcontreras]

We fail our hermanos and hermanas by doing this. I've made a concerted effort NOT to do this.

[we are mitú @wearemitu]

A new study found that over half of non-Spanish speaking Latinos feel “shamed” by their community. As one user said, "People shouldn't be shamed for either speaking Spanish, or not being able to speak it."
https://t.co/AhcFavBYAh

[L C @lcontreras]

The start of something good... #webdev

[L C @lcontreras]

@christinelu Yum. Why isn't this available in the 626?

[L C @lcontreras]

Amazing and a good decision for the health of all.

[The Associated Press @AP]

A South Dakota museum is closing after almost 40 years over concerns that the chemicals in its taxidermy collection could endanger visitors and staff. https://t.co/XwqSkon6kI

[L C @lcontreras]

@ScienceMagazine @Kurz_Gesagt @SciMagBooks The art here is beautiful

[L C @lcontreras]

@IyanlaVanzant Peace be with you. I am so sorry for your loss.