lewismessthecode

AI Research Engineer (Biology)
building

[lewismessthecode @leeeewisliu]

Introducing BioinfoFlow: bioinformatics that finally feels like 2026.

- Talk to an AI agent to start your analysis.
- Launch RNA-seq, GATK variant calling, single-cell — even run NVIDIA Parabricks whole-genome sequencing on your own RTX 4080+ rig.
- Watch every step of every run as a live, color-coded DAG.
- Organize everything into projects: runs, files, outputs, history, side by side.
- Reproduce any analysis with one click.
- Use it from the browser, the terminal (bif), or plug it into your own agent.
- English and 中文 from day one.
- Say goodbye to bioinformatics UIs stuck in the 2000s.

Know your own genome — run NVIDIA Parabricks WGS on your own PC 👇

Site: https://t.co/LkEUcnYdPf
Github: https://t.co/d7vmtDBxXe

[lewismessthecode @leeeewisliu]

@MaiYangAI 举手

[lewismessthecode @leeeewisliu]

@derrickcchoi codex desktop app 在 MacBook M1 Pro 上运行太烫了

[lewismessthecode @leeeewisliu]

this is the real basketball

[Kevin Durant @KDTrey5]

I remember asking assistant coach Mo Cheeks, what’s harder to do? Workout after practice or before?? I only asked cuz by time I would get to the gym, Russ was already done in the morning and I usually got mine in after practice. Mo like, “coming in before practice is probably harder”…since then, it’s been my routine….a lot of people looked at the emotions on the court and thought Russ was loud, nah to me, he was quiet and methodical. He lead by example and once the lights were bright, he let everything out and experienced pure freedom. It was inspiring as his teammate and everywhere I went, I seen it inspire people from all walks of life, crazy thing is, he didn’t say much, he just showed up. For 18 years. This basketball life is sacred to us as professionals, what we put into that court means everything. Some of us wish we could go back and do things with a little more intent and some can just wipe their hands and be satisfied with the time spent. Who u gonna be? We know what zero was on…keep inspiring in the next phase of life champ. I don’t care what happens, can’t erase what it was…The first YNs, finals run in our early 20s, all star games, seeing each other get injured and bounce back, the bus rides, plane rides, card games, jokes and arguments, the whole thing, memorable!! …to the whole Westbrook family, Nina, the kids, mama Westbrook, big Russ, Ray, Donnell, everybody from luezinger high and ucla and many more that I’m forgettin, much love and Congratulations on a iconic career.

[lewismessthecode @leeeewisliu]

@birdabo most of them are second hand information from english part of twitter

[lewismessthecode @leeeewisliu]

Spent a month building BioinfoFlow.

Anthropic: drops Claude Science.

Me: BioinfoFlow is cooked. 😂

[lewismessthecode @leeeewisliu]

Introducing BioinfoFlow: bioinformatics that finally feels like 2026.

- Talk to an AI agent to start your analysis.
- Launch RNA-seq, GATK variant calling, single-cell — even run NVIDIA Parabricks whole-genome sequencing on your own RTX 4080+ rig.
- Watch every step of every run as a live, color-coded DAG.
- Organize everything into projects: runs, files, outputs, history, side by side.
- Reproduce any analysis with one click.
- Use it from the browser, the terminal (bif), or plug it into your own agent.
- English and 中文 from day one.
- Say goodbye to bioinformatics UIs stuck in the 2000s.

Know your own genome — run NVIDIA Parabricks WGS on your own PC 👇

Site: https://t.co/LkEUcnYdPf
Github: https://t.co/d7vmtDBxXe

[lewismessthecode @leeeewisliu]

@FCHWPO 龙布朗牛逼

[lewismessthecode @leeeewisliu]

https://t.co/O0080Uczzp

[lewismessthecode @leeeewisliu]

My MacBook Pro M1 Pro has been getting super hot whenever I open the Codex Desktop app. After digging around, It looks more like a UI rendering issue. For now, the best fix is pretty simple: minimize the Codex window.

[lewismessthecode @leeeewisliu]

@sickdotdev Maybe it’s time to start a petition: bring back the Touch Bar on MacBooks.

[lewismessthecode @leeeewisliu]

@opencode no minimax sucks

[lewismessthecode @leeeewisliu]

@aleabitoreddit 你用中文写了这条推文，哈哈，是因为中文受众多吗？就让中文粉丝来助力你超过马斯克吧

[lewismessthecode @leeeewisliu]

The Chinese translation on X seriously sucks.

I end up copying and pasting posts into ChatGPT all the time because the translations from Grok are often inaccurate and unnatural.

please improve Grok’s Chinese translation quality @nikitabier @elonmusk

[lewismessthecode @leeeewisliu]

@FarzaTV @ycombinator soooooooo quick, it’s Jarvis

[lewismessthecode @leeeewisliu]

@LottoLabs but those open source models toC are bad, and chinese data are full of garbage, seldom people can use glm, deepseek’s website is hard to use. most chinese maybe using Doubao which is not a open source model

[lewismessthecode @leeeewisliu]

@EasonnLi 请问 Grok 生成这种不是有限制会和谐吗，请问你是怎么绕过去的

[lewismessthecode @leeeewisliu]

@elonmusk Elon is pushing again

[lewismessthecode @leeeewisliu]

笑死了， 突然想到 Aha moment 可以翻译成“卧槽时刻”

[lewismessthecode @leeeewisliu]

这两年旧金山的氛围，越来越有一种躁动甚至失衡的感觉。

我感觉结果上的分化，已经严重到前所未见的程度了。

过去五年里，大概有一小撮人——可能也就一万人左右——包括 Anthropic、OpenAI、xAI、Nvidia、Meta（也许还包括未来的一些公司）的员工，以及部分创业者，已经在 AI 浪潮里实现了远超“财富自由”的跃迁。粗略估算，他们很多人的净资产都已经超过了 2000 万美元。

而这群人之外的大多数人，会明显地产生一种感觉：

哪怕自己拿着一份已经相当高薪的工作（但年收入低于 50 万美元），老老实实干一辈子，好像也永远到不了那个层级。

更糟糕的是，裁员潮正在全面发生。很多软件工程师第一次开始怀疑，自己赖以生存十几年的核心技能，会不会突然就不再重要了。AI 几乎在一夜之间改写了大量岗位的日常工作方式。

于是，很多人的心理状态都开始发生变化。

第一，传统的职业晋升路径，突然看起来像爬错了楼。

越来越多人开始重新校准自己的人生路线：

我是不是该去创业？
现在加入 Anthropic / OpenAI 还来得及吗？
我是不是必须转 AI？
下一家会涨十倍的公司是哪家？

于是大家开始更频繁跳槽、更激进地谈薪，也越来越难安心待在原来的轨道里。

第二，是一种非常深层的“工作虚无感”。

很多人会想：

我为什么还要为了这点“零钱”拼命工作？
几年后我的岗位还存在吗？
如果 AI 最终会替代我，那现在努力的意义是什么？

尤其年轻人之间，“永久下层阶级（permanent underclass）”这种讨论越来越常见。你会发现，当一个人脑子里不断想着：

“如果我两年前加入 Anthropic，我现在可能已经退休了。”

那他其实很难再专注于眼前工作的价值感。

第三，是中层和偏资深管理者的集体瘫痪感。

他们很多人已经有家庭，有孩子，也没有精力或者社交网络再去“重新创业”一次。他们通常也并不具备真正的 AI 技能。

但与此同时，他们又隐约看得出来：

很多公司的 middle management，正在被 AI 一层层掏空。

于是他们处在一种非常尴尬的位置：
知道时代在变，但自己已经没有足够的可塑性了。

第四，其实连已经“赢了”的那群人，也未必快乐。

当然，没人会同情他们——这也很正常。

但很多突然暴富的人，其实会经历一种巨大的目的感坍塌。

有些人几年前年薪还不到 15 万美元，结果短短几年，资产直接变成五千万美元以上，而且中间几乎没有任何缓冲期。这种变化会直接把一个人的人生规划彻底打乱。

有的人开始陷入更强的比较心理；
有的人跑去纽约，“体验人生”；
还有一些人继续创业，但理由已经不是为了钱，而更像是在追逐身份感和存在感。

我曾经问过一个已经彻底“财富无意义化”的创业者：

“你为什么不直接把公司卖掉？”

他说：

“卖了以后呢？现在所有人都愿意跟我聊天。如果我卖掉公司，那我就只剩下钱了。”

我知道，很多人看到这些，会觉得这不过是硅谷的“香槟烦恼”。

但科技泡沫里的社会结构，本来就是扭曲的。

很多在世界其他地方已经算非常成功、非常富裕的人，放到湾区，其实也只是“普通”。

而且湾区有一个很特殊的地方在于：

长期以来，人们多少是相信“能力、智力、努力”和最终结果之间存在关联的。

所以，当你恰好生活在一次改变社会结构的技术淘金潮里，而你又隐约感觉：

“也许我差一点就能上船。”

那种心理折磨其实非常强烈。

很多人每天脑子里都在循环：

“我是不是站错地方了？”
“我是不是该搬去别的城市？”
“现在入场还来得及吗？”
“我最终会成功吗？”

对于那些怀着“改变命运”期待来到湾区的人来说，这种焦虑几乎是持续性的。

而最讽刺的是：

这种焦虑本身，往往又会进一步推动大家去创造那些让别人暴富的 AI 产品——因为每个人都希望，自己也能靠 vibecoding，写出通往财富自由的那段代码。

[Deedy @deedydas]

The vibes in SF feel pretty frenetic right now. The divide in outcomes is the worst I've ever seen.

Over the last 5yrs, a group of ~10k people - employees at Anthropic, OpenAI, xAI, Nvidia, Meta TBD, founders - have hit retirement wealth of well above $20M (back of the envelope AI estimation).

Everyone outside that group feels like they can work their well-paying (but <$500k) job for their whole life and never get there.

Worse yet, layoffs are in full swing. Many software engineers feel like their life's skill is no longer useful. The day to day role of most jobs has changed overnight with AI.

As a result,
1. The corporate ladder looks like the wrong building to climb.
Everyone's trying to align with a new set of career "paths": should I be a founder? Is it too late to join Anthropic / OpenAI? should I get into AI? what company stock will 10x next? People are demanding higher salaries and switching jobs more and more.

2. There’s a deep malaise about work (and its future).
Why even work at all for “peanuts”? Will my job even exist in a few years? Many feel helpless. You hear the “permanent underclass” conversation a lot, esp from young people. It's hard to focus on doing good work when you think "man, if I joined Anthropic 2yrs ago, I could retire"

3. The mid to late middle managers feel paralyzed.
Many have families and don't feel like they have the energy or network to just "start a company". They don't particularly have any AI skills. They see the writing on the wall: middle management is being hollowed out in many companies.

4. The rich aren’t particularly happy either.
No one is shedding tears for them (and rightfully so). But those who have "made it" experience a profound lack of purpose too. Some have gone from <$150k to >$50M in a few years with no ramp. It flips your life plans upside down. For some, comparison is the thief of joy. For some, they escape to NYC to "live life". For others still, they start companies "just cuz", often to win status points. They never imagined that by age 30, they'd be set. I once asked a post-economic founder friend why they didn't just sell the co and they said "and do what? right now, everyone wants to talk to me. if i sell, I will only have money."

I understand that many reading this scoff at the champagne problems of the valley. Society is warped in this tech bubble. What is often well-off anywhere else in the world is bang average here.

Unlike many other places, tenure, intelligence and hard work can be loosely correlated with outcomes in the Bay. Living through a societally transformative gold rush in that environment can be paralyzing. "Am I in the right place? Should I move? Is there time still left? Am I gonna make it?" It psychologically torments many who have moved here in search of "success".

Ironically, a frequent side effect of this torment is to spin up the very products making everyone rich in hopes that you too can vibecode your path to economic enlightenment.

[lewismessthecode @leeeewisliu]

通过 Mole 清理的时候不小心发现了Google Chrome浏览器的 4GB 本地大模型的权重，看来去年6月份到8月份就有了

[Tw93 @HiTw93]

顺着最近发布的 Mole Mac 这个事情，想给大伙分享一下我这两天经历的神奇时刻。感谢这个去年在三亚泳池边的小玩具项目，让我认识了很多海外有趣的开发者，各个国家的。

Mac 客户端陆续做了两个周末休息日。之前有不少国外用户提过，家里的父母、兄妹不会使用 CLI 但很想要这个功能，问能否出一个简单好用的桌面端，由于时间加上认为当时 Mole CLI 还没有达到我认为成熟的地步，一直拖到了现在。

Mole 发布也才半年，居然超过 50K star，500 个用户提交的 issue 清理建议、300 个高质量的功能 PR、100 位全球开发者的贡献，带来了可能比现在 CleanMyMac 这类工具更强大的清理能力。甚至因为在 README 挂了 2 张我用 Vercel 加速的图片，一周跑了 60T 流量，直接欠了 Vercel 80 刀，我才意识到用的人真的很多，那桌面端就可以做了。

Mole 桌面端的很多巧思都是开始做的时候才想到的。比如用行星来代表每一个功能，和我小时候喜欢看各种行星运行有关系，加上 10 年前学会前端后第一个特别想学的就是 WebGL，开始用 WebGL 来画行星，行星的特征和 Mole 做的事情可以很好呼应，所以把这个主题加了进来：

清理用地球，「雨洗旧土，尘随潮去」
卸载用火星，「红尘覆旧，轻装再行」
优化用水星，「近轨疾行，小修有声」
分析用木星，「远目成图，微处可见」
状态用太阳，「光不合眼，心跳长明」

好比小鼹鼠的挖掘探索从小地方到了大世界的感觉，但是依然很清静，不会打扰你。

还有一个设计小巧思，各个行星的贴面图我换了不下 10 次，从 NASA 官网下载挑选了很多，找到最合适的。其实每一个行星转的方向方位、转速、完成后的飞行效果特征均有参考实际的行星运行情况，这个过程也算是 AI Coding 中很有乐趣的部分。虽然感觉这些东西和 Mole 鼹鼠好像没有那么大的联系，完全可以做一个很简单的菜单栏点啥清理啥就行，但还是想着不能这样，用 AI 产生的赛博垃圾已经太多了，我需要做一个舒服一点的东西出来，让我的 token 不浪费，也为了不污染你的时间线。

当天晚上大概 10 点发布，很感谢很多朋友自发转发，也特别感谢很多用户来购买，甚至有不少小伙伴仅仅是因为 CLI 带来的好处特地来购买的。从晚上发布开始，这段时间我的手机几乎每 10 秒就有一次购买通知，iPhone Air 直接发烫掉电，欧美用户特别多，法国、德国各种币种，真的很神奇。购买量太高了，为了睡觉最后不得已把邮箱通知关了，早上起来还有非常多的持续购买。其实 Mac 桌面端还有很多需要补充的功能，也很感谢大家的包容，为了一个漂亮小玩具预付了 9 刀，我继续加油把功能做好才行。

我做事情很喜欢水到渠成，不喜欢短时间急切追求结果。这种长期持续迭代，持续认识很多新朋友，给到我很多的输入交流讨论，才是最宝贵的财富，特别有意思。

[lewismessthecode @leeeewisliu]

ChatGPT 现在免费版的模型好喜欢换行，像写现代诗一样，Custom instructions 好像也没办法限制他。