Lena Boehme

Postdoctoral Researcher & γδ T cell fan | studying T cell development in the human thymus @taghon_lab @UGent | she/her 👩‍🔬💻 |

[Lena Boehme @lenamboehme]

Our human thymus spatial atlas is finally published in @Nature! 🥳
Using a novel common coordinate framework we explored thymic tissue organisation, cell migration trajectories and molecular composition throughout development.
https://t.co/wRrQK4CApw @humancellatlas

[T Cell Team Taghon @taghon_lab]

🚨Out now in @Nature: Our spatial atlas of the developing thymus https://t.co/oxJEISJNmI
Together with @Teichlab @MarioniLab and Germain lab we present insights into the establishment of the thymic organ structure in pre- and postnatal life through a new spatial mapping approach.

[T Cell Team Taghon @taghon_lab]

🚨 Job alert!
The @taghon_lab (@ugent 🇧🇪) is looking for a Postdoctoral Researcher in molecular & computational immunology.
Join us to explore immune cell development in the human thymus using single-cell & spatial omics.
🔗 More info here: https://t.co/g9d8FzogU6
#ScienceCareers

[Lena Boehme @lenamboehme]

I'm beyond excited and super grateful to @FWOVlaanderen for supporting me for another 3 years with a senior postdoc fellowship! 🥳
Stay tuned for cool science on lineage decisions in human T cell development and the role of the thymic microenvironment. 👩‍🔬💻
@ugent @taghon_lab

[Lena Boehme @lenamboehme]

✨ New year, new opportunities:
Come join our team for some exciting projects on human γδ T cell development using single cell and spatial multiomics!🧑‍🔬💻 We're looking for PhD students and postdocs with interest/experience in computational biology. Reach out for more info!

[T Cell Team Taghon @taghon_lab]

📢 We're hiring!
Are you:
- Looking for a PhD or postdoc position?
- Interested in human γδ T cells?
- Curious about employing single cell and spatial technologies to study their development?
Then apply now to join our lab @ugent!
https://t.co/Tt5Nd3ubCc
https://t.co/WkbP354S84

[Lena Boehme @lenamboehme]

If you like scRNA-seq, you'll love CITE-seq. 😍Exploring thymocyte development through this multimodal data set has been utterly fascinating and the level of detail captured by RNA & protein is a real game changer. Get a glimpse of it with our shiny app✨
https://t.co/CQHMubcsoH

[T Cell Team Taghon @taghon_lab]

To make our fantastic CITE-seq data set of postnatal thymocytes accessible to the community, we have launched a shiny web app for interactive exploration. Go check it out! https://t.co/qYM41PqgwF
Moreover, scRNA-seq and Visium spatial data can be found at https://t.co/IhfPWb2gvH

[Lena Boehme @lenamboehme]

Big shout out to the amazing team behind this collaborative effort! @YayonNadav @kedlian @AndreaJRadtke @teichlab @taghon_lab
Super grateful to have had such creative, talented and generous companions on this insightful journey.

[Lena Boehme @lenamboehme]

Our human thymus spatial atlas is finally published in @Nature! 🥳
Using a novel common coordinate framework we explored thymic tissue organisation, cell migration trajectories and molecular composition throughout development.
https://t.co/wRrQK4CApw @humancellatlas

[T Cell Team Taghon @taghon_lab]

🚨Out now in @Nature: Our spatial atlas of the developing thymus https://t.co/oxJEISJNmI
Together with @Teichlab @MarioniLab and Germain lab we present insights into the establishment of the thymic organ structure in pre- and postnatal life through a new spatial mapping approach.

[European Hematology Association @EHA_Hematology]

Congratulations to this year’s CBTH Scholars! Throughout the program, scholars explored a range of topics and were guided by mentors to elevate their projects to new heights. In addition to advancing their own research, they delved deeper into these key areas:

👉 Bayesian Statistics
️👉 Science Communication 
👉 Multi-Layered Data Integration
👉 Data Visualization
👉 Proteomics
👉 Epigenetics

Would you like to join our next cohort? This free program will open for applications in June 2025! Don’t miss out on this amazing opportunity to elevate your skills in Computational Biology.

[Lena Boehme @lenamboehme]

Porto with the best colleagues 🤗 Truly fascinating talks and posters at #ThymE24 and amazing to see all the different takes on our favourite organ.
@Malyamooo @VhJolien

[Lena Boehme @lenamboehme]

Big thank you to @EBItraining @EHA_Hematology for selecting me for this year's #CBTH cohort! Had a great time at the first workshop - many inspiring conversations and lots of ideas to take on board for the upcoming months of data analysis. 🧑‍💻

[EMBL-EBI Training @EBItraining]

A big thank you to everyone involved in this week's joint @EBItraining and @EHA_Hematology computational biology training in hematology (CBTH) course.

2025 applications are now open if you want to be in the next cohort of early-career researchers: https://t.co/WM6juTqJBa

[Lena Boehme @lenamboehme]

Took us long enough but after 2+ years the thymus team finally managed to meet in 3D. 🎉 Thanks for having me @YayonNadav @kedlian!

[Magali IRLA Lab @IrlaLab]

The full program of the next European thymus meeting, "ThymE 2024", is now online 👇
https://t.co/nBnv8xbwAC

[Lena Boehme @lenamboehme]

4 days of #EMBOMultiOmics have been incredibly inspiring, enlightening and fun (!). Returning home with so many new ideas - can't wait to dive back into my data. Thanks to all the fantastic trainers and other participants for the discussions and suggestions 🤗 @EMBLEvents

[Lena Boehme @lenamboehme]

Wonderful summary! 👏

[Felix C Richter @CleeteRichter]

Really pleased to share our @preprintclub #highlight on the #preprint of the @teichlab and @YayonNadav @kedlian @lenamboehme, which used a clever approach to yield a detailed #spatial molecular and cellular map of #human #thymic development. Inspiring work, opening new questions.

[Dudakov Lab @Dudakov_Lab]

@Es_cheri_chia @CellCellPress For all things #thymus, next up in the Global Thymus Network meetings is Porto in May '24. Organized by (the twitterless) Nuno Alves, with @KruegerLab @TheAbramsonLab @taghon_t @IrlaLab @Vera22380790 https://t.co/MKlVOyNSvc

[T Cell Team Taghon @taghon_lab]

Congrats to our PhD student Michaela for winning the @BDBiosciences @SING_Gent abstract competition! We're super excited to use the #BDRhapsody system to study the role of GATA3 mutations in the development of T-ALL. #singlecell #ugent

[Lena Boehme @lenamboehme]

@taghon_t @ugent https://t.co/jUA3ksOmnz

[Lena Boehme @lenamboehme]

📢Our new preprint is out: We built a spatial atlas of the developing human thymus based on a continuous organ axis.
Fantastic collaboration with the labs of Sarah Teichmann @sangerinstitute & Ron Germain @NIH & proud of @YayonNadav @kedlian @AndreaJRadtke for making this happen.

[Teichlab @teichlab]

Happy to share our work, a comprehensive single cell & spatial atlas of the human thymus, which uses our newly established common coordinate framework for the thymus, the Cortico-Medullary Axis (CMA), to spatially explore thymic development.#ThymusCCF https://t.co/4PS1MzCRkf

[Lena Boehme @lenamboehme]

Our atlas harbours a vast collection of thymus data sets: scRNA-seq, spatial transcriptomics, multiplex protein imaging and - my personal favourite - 143-plex CITE-seq data, which which allowed us to annotate paediatric thymocytes at unprecedented resolution. 🤩
@taghon_t @ugent

[bioRxiv Immunology @biorxiv_immuno]

A spatial human thymus cell atlas mapped to a continuous tissue axis https://t.co/43kGPAIy7z #biorxiv_immuno