El Grande GangStar

Chess aficionado - No ego here - Killer Instinct

[Adriana Flowers 🌸 @Adriana19Flower]

Women were given unlimited rights and freedom and this is what they did with that freedom:

-Kill their babies and passionately defend their right to do so
-Prostitute themselves and give their bodies to countless men
-Divorce and tear apart their children’s lives to chase rom-com fantasies
-Vote for illegal immigrants and mass migration to tear apart our country
-Support all female sexual degeneracy
-Defend women that lie about rape
-Defend female killers

The feminist experiment is over. Men and women are not equal and we will never be.

[Rahul @sairahul1]

Grok Bot is the best AI agent right now

It gives you an army of agents that can do work for you 24/7

If you set it up correctly, you gain super powers

In this article, I cover setting up Grok Bot, use cases, plugins and what makes Grok Bot so good https://t.co/4gzbtLmVbr

[Shaun Maguire @shaunmmaguire]

This legend got roasted by the French newspaper Le Monde

Then instead of putting his head down as most European elites have typically done

He penned a masterpiece articulating his heroic contributions to France

THIS IS HOW YOU SAVE EUROPE

Bravo @BernardArnault

[Danny @DjokovicFan_]

Novak Djokovic vs. Rafa Nadal vs. Roger Federer — a complete career comparison:

Grand Slams:
🇷🇸Djokovic: 24 ✅
🇪🇸Nadal: 22
🇨🇭Federer: 20

ATP Finals:
🇷🇸Djokovic: 7 ✅
🇨🇭Federer: 6
🇪🇸Nadal: 0

Masters:
🇷🇸Djokovic: 40 ✅
🇪🇸Nadal: 36
🇨🇭Federer: 28

Olympics (singles):
🇷🇸Djokovic: Gold + Bronze ✅
🇪🇸Nadal: Gold
🇨🇭Federer: Silver

Big Titles:
🇷🇸Djokovic: 72 ✅
🇪🇸Nadal: 59
🇨🇭Federer: 54

Total Titles:
🇨🇭Federer: 103 ✅
🇷🇸Djokovic: 101
🇪🇸Nadal: 92

H2H record:
🇷🇸Djokovic leads Nadal 31-29 and Federer 27-23 ✅
🇪🇸Nadal trails Djokovic 29-31 and leads Federer 24-16
🇨🇭Federer trails Djokovic 23-27 and Nadal 16-24

Weeks at #1:
🇷🇸Djokovic: 428 ✅
🇨🇭Federer: 310
🇪🇸Nadal: 209

Year-end #1:
🇷🇸Djokovic: 8 ✅
🇨🇭Federer: 5
🇪🇸Nadal: 5

Overall win %:
🇷🇸Djokovic: 83.18% ✅
🇪🇸Nadal: 82.57%
🇨🇭Federer: 81.98%

Top 10 wins:
🇷🇸Djokovic: 266
🇨🇭Federer: 224
🇪🇸Nadal: 186

Top 10 win %:
🇷🇸Djokovic: 68.56% ✅
🇨🇭Federer: 64.55%
🇪🇸Nadal: 63.92%

Top 5 wins:
🇷🇸Djokovic: 129 ✅
🇨🇭Federer: 104
🇪🇸Nadal: 93

Top 5 win %:
🇷🇸Djokovic: 60% ✅
🇪🇸Nadal: 59.62%
🇨🇭Federer: 58.1%

Peak points total:
🇷🇸Djokovic: 16,950 (#1 all-time) ✅
🇨🇭Federer: 15,495 (#2 all-time)
🇪🇸Nadal: 15,390 (#3 all-time)

Peak ELO rating:
🇷🇸Djokovic: 2629 (#1 all-time) ✅
🇪🇸Nadal: 2552 (#4 all-time)
🇨🇭Federer: 2550 (#5 all-time)

ITF World Championships:
🇷🇸Djokovic: 8 ✅
🇨🇭Federer: 5
🇪🇸Nadal: 5

Slams on a hard court:
🇷🇸Djokovic: 14 ✅
🇨🇭Federer: 11
🇪🇸Nadal: 6

Slams on a grass court:
🇨🇭Federer: 8 ✅
🇷🇸Djokovic: 7
🇪🇸Nadal: 2

Slams on a clay court:
🇪🇸Nadal: 14 ✅
🇷🇸Djokovic: 3
🇨🇭Federer: 1

Big Titles indoors:
🇷🇸Djokovic: 14 ✅
🇨🇭Federer: 6
🇪🇸Nadal: 1

Holes in resume:
🇷🇸Djokovic: None ✅
🇨🇭Federer: Olympics, Monte Carlo, Rome
🇪🇸Nadal: ATP Finals, Miami, Paris

Notable achievements:
🇷🇸Djokovic: Non-Calendar Year Grand Slam; Triple Career Grand Slam; Double Golden Masters; Channel Slam ✅
🇨🇭Federer: Channel Slam
🇪🇸Nadal: Channel Slam

Conclusion:
Novak Djokovic is the undisputed greatest ever.

[Boring_Business @BoringBiz_]

Your success in life is almost always directly correlated with how many uncomfortable conversations and situations you are willing to put yourself into

[Boring_Business @BoringBiz_]

I think about this quote often. The only alpha in markets is your difference in opinion vs consensus

If you just follow consensus, you are generating beta

That is fine for people who just want to track returns, but that is not what LPs pay you for if you are running a fund

[El Grande GangStar @lion2128]

How to survive AI mass replacement (and escape wage slavery) https://t.co/2y1go10J9u

[Ray Dalio @RayDalio]

https://t.co/ZNaQtDhoH6

[Boring_Business @BoringBiz_]

the wonders of compounding becomes visible when you pick a skill, get just a little bit better at it every day, and then realize years later that people come to ask for your expertise on that same topic

that is essentially what you sign up for when pursuing high intensity careers like banking and private equity

you get worked a ton, but start to build expertise through sheer reps. after working on 10 deals, the eleventh one starts to make a little more sense. after spending time on 4 deals in the same sector, the fifth one becomes a little easier to underwrite

after enough time, young analysts and associates come to you for advice. Clients and PMs start to value what you think and rely on you for decision making

it is probably the most satisfying part about pursuing expertise in something. all about watching your own skillset compound over time

[Sahil Bloom @SahilBloom]

I'm convinced that 99% of success is just the ability to outlast uncertainty. The one who can tolerate the most uncertainty is the one who will eventually win.

[FIFA @FIFAcom]

The reason Japan fans clean the stadium after each game. Respect. 🤝🇯🇵

[David Sacks @DavidSacks]

AI is the new Climate Change.

[Bryan Johnson @bryan_johnson]

Here's a snapshot of the biological insult from international travel. It takes your body over two weeks to fully recover.

It's a big price tag.

One international trip per quarter is a reasonable balance.

Time to recover:
> sleep duration: 2 days
> grip strength: 5 days
> mood: 1 wk
> cortisol: 9 days
> sleep quality: 2 wks
> blood glucose: 2 wks

[El Grande GangStar @lion2128]

OpenAI, Anthropic & Microsoft CEOs Call for Stricter Laws Against AI Biothreats - MIT Sloan Management Review Middle East https://t.co/OncgCIaJt4

[Brivael Le Pogam @brivael]

Dans le manifeste "techno-optimiste" de Marc Andreessen, il y a une phrase qui m'a marqué :

"Our enemies are not bad people – but rather bad ideas."

Nos ennemis ne sont pas des mauvaises personnes. Ce sont des mauvaises idées.

Prenons Jancovici. L'homme est brillant, sincère, travailleur. Il ne se lève pas le matin en se disant qu'il va nuire à l'humanité. Mais l'idée qu'il porte la décroissance, le rationnement, la frugalité érigée en horizon civilisationnel est une idée profondément destructrice. Elle prend des esprits brillants et les transforme en commissaires politiques d'un futur appauvri.

Et le plus fascinant, c'est ce que cette idée fait aux gens qui l'adoptent.

Dans mon entourage, une grosse partie de mes amis est sur cette ligne décroissantiste, avec tout le package qui va avec. L'argent c'est mal mais ils en veulent. Il faut moins prendre l'avion mais ils rêvent de voyager partout. Il faut consommer moins mais ils ne renoncent à rien de ce qu'ils aiment vraiment.

Et tous ont un point commun : ils sont déprimés. L'un d'eux m'a même confié qu'il était sous antidépresseurs.

Ce n'est pas un hasard. C'est mécanique.

Quand tu crois que ton désir de vivre, de créer, de t'élever est moralement suspect tu te détruis de l'intérieur. Tu passes ta vie à t'excuser d'exister. Tu vis dans la dissonance permanente entre ce que ton corps veut (plus, mieux, plus loin) et ce que ton idéologie t'ordonne (moins, sobre, immobile).

D'où ma théorie :

Quand on pense quelque chose de fondamentalement faux décroissance, communisme, extrémisme religieux (de tout ordre) ce n'est qu'une question de temps avant que ça devienne vraiment destructeur.

D'abord pour soi. Puis pour les autres.

Les mauvaises idées tuent. Lentement chez ceux qui y croient, brutalement chez ceux qui les subissent.

C'est pour ça que la bataille des idées n'est pas un luxe d'intellectuel. C'est la bataille la plus importante de notre époque.

[Chubby♨️ @kimmonismus]

One injection, 62% lower LDL - permanently. Gene editing for cholesterol is here.

.@cremieuxrecueil is correct. Besides GLP-1 antagonist like Ozempic or, more recently, Retatrutide, this is probably the next breakthrough that is almost impossible to put into words.

Verve Therapeutics (Eli Lilly) just published Phase 1 results for VERVE-102 in the NEJM.

It's a single-infusion base-editing therapy that inactivates PCSK9 in the liver. At the highest dose, PCSK9 dropped 88% and LDL cholesterol fell 62%. Reductions held for at least a year.

35 patients with familial hypercholesterolemia or premature coronary artery disease. No dose-limiting toxicities. Main side effects: mild infusion reactions and transient liver enzyme elevations.

Still Phase 1, still small, no cardiovascular outcome data yet. But the proof of concept for permanent, one-shot LDL reduction via gene editing is real.

This is an absolute game changer and im not exaggerting.

Elevated LDL cholesterol is responsible for an estimated 4.4 million deaths every year worldwide and remains the single biggest modifiable driver of cardiovascular disease, the leading cause of death globally.