lipio

[Rohan Paul @rohanpaul_ai]

Truly wild story 🤯. A new era of "citizen science" is beginning.

An engineer with no medical training used ChatGPT and Google’s Alphafold (AI protein sequencer) to build a working cancer vaccine from scratch.

He turned raw genetic data into a custom mRNA vaccine that shrank his dying dog's tumor by 50%.

Paul Conyngham spent $3000 to get the DNA sequences of his dog's healthy blood and the cancerous tumor.

He was staring at gigabytes of raw genetic code without having any clue how to read biological data.

This is exactly where ChatGPT became the crucial missing link in his process.

He used ChatGPT as a high-level biological consultant to figure out how to compare the two DNA samples and spot the exact mutations causing the cancer.

ChatGPT gave him the step-by-step instructions to run the data pipelines and pointed him toward an AI tool called AlphaFold to map the physical shape of the damaged proteins.

The chatbot basically translated complex oncology concepts so he could write a half-page chemical recipe for an mRNA vaccine.

This mRNA is just a genetic instruction manual that tells the immune system how to recognize and attack those specific mutated cancer cells.

University researchers were blown away by his formula and manufactured the physical vaccine for him.

A veterinary expert then injected the dog, and within weeks the massive tumor had halved in size.

[lipio @lipio]

다시 사회 초년생이 되어 회사를 선택할 수 있다면 1초의 망설임도 없이 뉴럴링크를 택하겠다. https://t.co/YxbMg3gLam

[lipio @lipio]

도구로서의 AI와 존재로서의 AI

[Yishan @yishan]

My AI investment thesis is that every AI application startup is likely to be crushed by rapid expansion of the foundational model providers.

App functionality will be added to the foundational models' offerings, because the big players aren't slow incumbents (it is wrong to apply the analogy of "fast startup, slow incumbent" here), they are just big. Far more so than with any other prior new technology, there is a massive and fast-moving wave that obsoletes every new app almost as fast as it can be invented. There is almost no time to build a company and scale it.

There are two ways AI application startup founders can make money:
- Make a flash-in-the-pan app that generates a ton of cash and bank the cash (my estimate is that you have about 12-18 months cashflow generation)
- Make a good enough app that you get acquired by one of the big players for sufficient equity

The situation is highly unstable - we don't know if it's going to crash or go to the moon but both scenarios make it very unlikely that any AI application startup will independently become a generational supercompany (baseline odds are low to begin with).

The best odds are finding an application niche in a highly specialized field with extremely unique and specific data barriers, ideally ones relating to real atoms (hardware or world-related) data and not software/finance.

[けん🇯🇵🇺🇸🇮🇱 @ken_sword_ken]

今の老人は村上春樹だ
老人のイメージをいい加減アップデートしろよ
ビートルズ聴いてマック食ってジーパン履いて過ごしてきたのが今の老人なの

[lipio @lipio]

창업자 모드와 관리자 모드 https://t.co/6uxoovAhzI

[ChrisUniverse 🗽 @ChrisUniverse]

This is Apple’s Microchip under a microscope 🔬😳

Now do you believe we can build UFO’s? 🛸

[MATT GRAY @matt_gray_]

This is what great writing looks like:

[Journey @atmostbeautiful]

깊이 읽기를 위한 매체로서 책의 고유한 가치는 내용보다는 오히려 형식에 있다고 할 수 있다. 독서는 그 형식에 정신이 충실히 조응하면서 이뤄진다.

[하워드🍟⚡️ @Notesfor_X]

스트레스는 ‘해야하는 것’을 알면서도 ‘주저할 때’ 찾아온다.

[George from 🕹prodmgmt.world @nurijanian]

Jeff Bezos on writing well

[리유 @R_E_Y_O_U]

UI 구리면 눈이 썩는 것
UX 구리면 속이 썩는 것

[The Culturist @the_culturist_]

This church has been under construction for 124 years. In 2026, it will become the tallest in the world.

It isn't funded by the state or even the Church — it's being built entirely by the people.

And it's far more impressive than you realize... (thread) 🧵

[Kelsey Smith 💛🎞️ @NotKelseySmith]

A good night on 35mm film (open for a surprise)

[북토피아 @book_nutshell]

"상대가 말하는 중에 치고 들어갈 기회를 엿보거나 말이 언제 끝날지 조바심을 낸다면 나는 듣지 않는 것이다. 이는 상대의 말을 경청의 대상이 아닌 내가 할 말의 재료로 삼는 것이다."

<듣기의 말들>박총

[Andrej Karpathy @karpathy]

Reading a tweet is a bit like downloading an (attacker-controlled) executable that you instantly run on your brain. Each one elicits emotions, suggests knowledge, nudges world-view.

In the future it might feel surprising that we allowed direct, untrusted information to brain.

[Aravind Srinivas @AravSrinivas]

1998-2023: Search
2023-?: Ask
?- : Do

[Drex⚡️ @drex_dsgn]

Life comes with a great game pre-installed.

It’s called Walking.

All you have to do to start is go for a walk outside.

Then it’s somewhat random, but every few thousand steps or so you will find yourself reliably rewarded with a great idea.

It’s free to play, forever.

@0FJAKE