Luke Goodsell @lukegoodsell.bsky.social

Director of Bioinformatics Software Development working on clinical precision immunooncology.

[Ben Dicken @BenjDicken]

You asked for it, so here it is.

Visualizing CPU cache speeds relative to RAM.

Cache optimization is important too!

[John Burn-Murdoch @jburnmurdoch]

I think this article officially marks Ultra-Processed Foods™️ graduation into full-blown pseudoscience.

Not sure if my fave is

“A red flag for UPF is if it’s made by a multinational company”

or

“Plain salted crisps are not UPFs but flavoured ones are”

https://t.co/mfBGQppyvw

[Luke Goodsell @lukegoodsell.bsky.social @luke_goodsell]

What a way to end a paper: "We believe that our new development will be a brand-new historical event that opens a new era for humankind." https://t.co/B822cAOs5r

[Luke Goodsell @lukegoodsell.bsky.social @luke_goodsell]

@pepetideo #fog2023 is a shitshow - 1h30m queueing to get in, and then there's no room to get to the keynotes. It really is just a funnel to get people to the sponsors' stands and nothing more.

[Hussein Tawbi, MD, PhD @HTawbi_MDPhD]

Incredible achievement positive Phase 3 trial with TIL congrats @HaanenJohn & colleagues @NKI. Game changer/new era to improve patient outcomes. FDA approval never too soon! Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma | NEJM https://t.co/mTjCqwGp5v

[David S. Goodsell 🏳️‍🌈 @dsgoodsell]

"HIV-Infected Cell" shows a T-cell with integrated HIV-1 DNA (thin white lines at upper right) and viruses assembling and budding at the cell surface. Full-size files, hand drawn at a scale of 1 nm/pixel, are free for use at: https://t.co/MA7Asr2SDy and https://t.co/X3Oia9l3yl.

[Adam Phillippy @aphillippy]

"The complete sequence of a human Y chromosome" ✅ thanks to @ArangRhie @sergeynurk et al! #T2T 🧵 https://t.co/RCahEaLQgC

[Luke Goodsell @lukegoodsell.bsky.social @luke_goodsell]

Miserable news, especially at this time of the year. My heart goes out to all those who lost their jobs through no fault of their own.

[James Waldron @JamesPharma]

The triple whammy yesterday from SQZ, Synlogic and Oncorus means we've recorded 22 biotech layoff announcements in November alone. Times are clearly still very tough for the sector
https://t.co/4fVq10HYdH

[Luke Goodsell @lukegoodsell.bsky.social @luke_goodsell]

New word: inclemental: weather that gets progressively worse.
#SkepticsGuideToTheUniverse

[Ed Markey @SenMarkey]

One of your companies is under an FTC consent decree. Auto safety watchdog NHTSA is investigating another for killing people. And you’re spending your time picking fights online. Fix your companies. Or Congress will.

[Lior Pachter @lpachter]

Why are they selling poppies, Mummy?
Selling poppies in town today.
The poppies, child, are flowers of love.
For the men who marched away.

[Alice R Fraser @aliterative]

The thanklessness becomes part of the pride. You must be special, because most people would need to be treated well or paid properly to hold the world on their shoulders for a thousand years. These are the Atlases who never shrug.

[Luke Goodsell @lukegoodsell.bsky.social @luke_goodsell]

British political discourse has been so jingoistic and infantile over the last few years that even a modicum of civility and talk of cooperation is a huge relief.

[Mujtaba Rahman @Mij_Europe]

The first line of @RishiSunak statement here is very good. Suggests he sees 🇫🇷🇬🇧 relationship as more than a dartboard for Tabloid point scoring which is what it became for @BorisJohnson and @trussliz . Remains to be seen whether it means anything, but good signal so far

[Luke Goodsell @lukegoodsell.bsky.social @luke_goodsell]

@PaoloDiTommaso Don't worry, Musk will be editing your tweets for you very soon: https://t.co/H7OV1bLRQj

[Read Jackson Rising @JPHilllllll]

Elon Musk is again claiming that he’s all about free speech. So let’s look at the record. Here’s thread with just a few of the countless examples showing he couldn't care about it less (🧵)

[Li Song @mourisl]

T1K can start from either FASTQ file or an BAM file. Here, we compared T1K's efficiency with arcasHLA and OptiType's on 10 large RNA-seq samples. T1K took about 40 minutes and 20G memory to process an RNA-seq sample with 100M read pairs. This was comparable to arcasHLA.

[Luke Goodsell @lukegoodsell.bsky.social @luke_goodsell]

"Fado is the Portuguese [people] in music form ... It is played with vigour not with rigour"

[Luke Goodsell @lukegoodsell.bsky.social @luke_goodsell]

@xkcdComic This will make @LHDNAHulk angry, and you won't like @LHDNAHulk when they're angry.

[Luke Goodsell @lukegoodsell.bsky.social @luke_goodsell]

This sounds like the premise for another great podcast series by @aliterative 😃

[XKCD Comic @xkcdComic]

Space Adventure https://t.co/PbqVrszow7 https://t.co/YXJLaj5DAY

[Luke Goodsell @lukegoodsell.bsky.social @luke_goodsell]

I wonder what @LHDNAHulk thinks of ham-fisted visual metaphors?

[Aaron Javitt @AaronJavitt]

Over half of the peptides in the #immunopeptidome are still unidentified!
Check out our new paper in @NatureBiotech where we develop PROMISE to identify modified HLA peptides and illuminate🔦 MS dark matter, revealing new classes of cancer antigens.
https://t.co/cYRScSyeJ6🧵1/7