Luke Blagdon Snell

Clinical lecturer, pathogen genomics & complex COVID @KingsCollegeLon @GSTTnhs @kingscollegenhs

[Cabinet Office @cabinetofficeuk]

Minister @patmcfaddenmp & Lord Vallance visited @GSTTnhs to see UK tech enabling rapid bedside diagnosis of respiratory infections.

The project with @OxfordNanopore is being rolled out to up to 30 NHS Trusts.

[Luke Blagdon Snell @lukebsnell]

@LongDesertTrain The main thing we need is an nsp5 inhibitor that has limited drug-drug interactions (ie is not dependent on CYP3A4 metabolism). Interested in ibuzatrelavir’s progress.

[Luke Blagdon Snell @lukebsnell]

@BMA_JuniorDocs ‘If this offer is accepted… we will remain on average 20.8% behind’ -BMA … Get serious.

[Luke Blagdon Snell @lukebsnell]

@DevanSinha Hard disagree. ‘If this offer is accepted… we will remain on average 20.8% behind’ -BMA. Who accepts the first offer? The real trade unions are laughing.

[LGC in partnership with ATCC @ATCC_LGC]

For this week's #MicrobeMonday, we wanted to share this fascinating podcast from @Letstalkmicro1 🦠 🎙️

Listen now to hear @LaraPayne85, @lukebsnell and @madelaam discuss how the novel species Variovorax durovernensis was discovered and the story behind its name ⬇️

[Journal of Hospital Infection @jhieditor]

💦@lukebsnell & team use nanopore metagenomics & other measures to assess the microbiome, resistome & effects of decontamination in hospital sinks
💧Metagenomics can measure the composition of the drainome & assess decontamination interventions
https://t.co/TsJrGXTWyW

[Luke Blagdon Snell @lukebsnell]

Massive congrats to @madelaam & @jonathanCIDR for @Synnovis, @KCLImmunoMicro and @GSTTnhs.

[Luke Blagdon Snell @lukebsnell]

Same day @nanopore respiratory metagenomics for pneumonia; bacteria, fungi and viruses in one tube. We are approaching the holy grail of infectious diseases diagnostics https://t.co/uFWUwqcQ65

[Luke Blagdon Snell @lukebsnell]

Our workflow picked up antimicrobial resistance genes and plasmids. Also a hint of novel resistance genes, we are investigating...

[Luke Blagdon Snell @lukebsnell]

'The drainome' - just published by @jhieditor: using @nanopore metagenomics and other measures to assess the microbiome, resistome and effects of decontamination in hospital sinks. https://t.co/ylg9Gkq3b4 @simon999 @madelaam @jonotter @jonathanCIDR

[Luke Blagdon Snell @lukebsnell]

we need to make sure our decontamination interventions are effective - this decontamination did not change microbial counts and led to expansion of Pseudomonas - what's the point?

[Luke Blagdon Snell @lukebsnell]

@GaiaNebbia and @jonathanCIDR discussing our implementation of rapid, unified metagenomics for detection of bacteria, viruses, and fungus in pneumonia. Manuscript coming soon! @madelaam @nanopore #nanoporeconf

[Alfredo Maldonado-Barrueco @alfredomaldo]

Congrats to @lukebsnell @madelaam for your oral presentation at #ECCMID2024 #ESCMIDGlobal 👏🏼

🧬| The drainome: metagenomics of sink wastewater on hospital wards can monitor antimicrobial resistance and identify reservoirs of carbapenamase-producing organisms |🚰

[Letstalkmicro @Letstalkmicro1]

Happy Friday! A new episode is now available. Tune in to learn about Variovorax durovernensis, a novel species . Link in comments.

@lukebsnell @LaraPayne85 @madelaam @GoodpodsHQ

#microbiology #MedTwitter #IDtwitter #medlabsci #podcast #Science #nhs #stem

[Eoghan de Barra @EoghandeB]

Great to collaborate with UK partners & share our experience of therapies for severe and persistent COVID in B cell deplete patients @RCSI_Irl @UCD_Research @GSTTnhs @IDSIreland @AimeeMcgreal @HIVTox https://t.co/GIWlTWHLNz

[Michael Calderwood, MD, MPH @CalderwoodMD]

Multicenter case series data in patients with persistent SARS-CoV-2 infection (median 103 days) in the setting of CD20 depleting therapy. Most received prolong Paxlovid (median 10 days, as long as 18 days) plus sotrovimab or IVIG. Lesser # got remdesivir. https://t.co/hgl3rQlIBW

[Paddy Mallon @HIVTox]

Great to see this case series published. Difficult to treat - persistent #COVID19 infection. Great collaboration across UK and Ireland - the All #Ireland Infectious Diseases Cohort @CEPHR_UCD @RCSI_Irl @ucddublin