Many years in the making - thrilled this is submitted! Convergence is driven by the acquisition of iuc and rarely results in phenotypic virulence. Complete with a one of a kind global Kpn plasmidome landscape and collection !
New preprint out! @AnjaliSapre@luluScience and co. mapped the evolutionary routes of convergence in K pneumo. Pop analysis of >1,400 global genomes & 7,500 closed plasmids to see how #AMR & virulence genes come together and impact phenotypes. https://t.co/VmUymZyskh
Brilliant talk from .@luluScience on profiling plasmids of global collection of Klebsiella pneumoniae to understand how resistance and virulence genes converge in a strain. #KLEBS2024
Training workshop for our collaborators @NMRL Zimbabwe funded by @gatesfoundation to investigate the association of #typhoid with protists in wastewater but will have a positive impact for surveillance including #AMR Thanks to @tapfumamashe, @tweakyaustin, Michaela and Petros
Our new paper with Tom Russo’s lab is out in @eBioMedicine We took out individual genes, combinations, or the whole virulence plasmid to measure their relative contribution in K. pneumoniae hypervirulence #hvkp@KlebClub https://t.co/LSmJxJBKN4
Registration for the 2024 (Oct 19-27) ICARe course https://t.co/QecUntfSPS is open until July 28. Be 1 of 40 selected participants and join Patrice Courvalin, @Faecal_flora, Heinz Moser and 30+ experts on #AMR and #drugdiscovery for a full week in #Annecy
https://t.co/QecUntfSPS
This is great paper and but I got to admit (though I am biased of course) not a single mention of the work done by DoD within the National Action Plan CARB program is a bit disappointing…
I am very excited to share my newest article on virulence of #Klebsiella pneumoniae clinical isolates published today in @NatureComms. A big thank you to all of my co authors for their hard work! Including 5 grad students and 4 undergrads. #Microbiology
https://t.co/WWGvMlgDAB
Fully funded PhD opportunity in my team; part of
@LSHTM, @NU_kouhou collaboration with Dr Daniel Inaoka and Prof. Toshio Kodama at Nagasaki Uni (https://t.co/rjQE1my5fk) dissecting the functions of the Campylobacter jejuni Type VI Secretion System (T6SS) effectors 🦠☕️🥼🧫👩🏾🔬🧑🔬
Our latest paper is out in preprint! https://t.co/1Ui9F6lnz9 With routine WGS we detected an outbreak of MDR Pseudomonas with cases spanning > 10 years! Turns out contaminated sinks in ICU rooms were part of the problem. Cases are slowing down now.
SIX extensively drug resistant isolates recovered from an injured Ukrainian soldier including ST-395 K. pneumoniae that was non-susceptible to all antibiotics tested. Long read sequencing underway!! @Fr_Lebreton@Brendan67357746 Ting Luo Patrick McGann
https://t.co/rZssO67y8L
@Fr_Lebreton@wrair All isolates are FREE and can be requested from BEI Resources under catalogue #NR-55604 (https://t.co/FcBkhZ6xDM). We are having fun seeing where they go! Stay tuned for more data on this panel! @Fr_Lebreton (3/3)
As of May 2023, our panel of 100 diverse Klebsiella pneumoniae clinical isolates have been requested and shipped to 151 academic and industry labs in 21 countries! @Fr_Lebreton@wrair (1/3)
Our paper describing these isolates/genomes for the research community was recently published in Microbial Genomics: https://t.co/FldQ1zNLdL @Fr_Lebreton@wrair (2/3)
Thrilled!
The #Klebsiella Diversity Panel ordered last weeek is already paying off .. the shipping costs!
We mined the genomes searching for a specific mutation which results in an interesting colony morphotype -similar to👇🏼👇🏼
from @schauflerlab 1/2
https://t.co/1VBlnggpM1