Our first feelgood foray into translational research: Perampanel can be therapeutic for patients with overactive GRIA variants.
Half the length of the first submission, but I still like it and it takes less time to read... @CureGrin@JulieZiobro@uclnpp
https://t.co/52zoj0vQ17
@Annalisa4fun Honorary? Hah!
I was wondering what might be in there after all these years... but then I couldn't help admiring the correctly used apostrohe...
Just out – our new paper on the actions of the TARP γ8-selective AMPAR blocker JNJ-55511118. Great work from (the far speedier tweeter) @IanDCoombs and Craig Sexton @uclnpp.
https://t.co/6ol4DAWi1h
Just posted @medRxivpreprint – the use of perampanel in a patient with a #GRIA2 gain-of-function variant. Enormous thanks to the patient and family, and to @JulieZiobro and @CureGRIN. All driven by the excellent @IanDCoombs@uclnpp.
https://t.co/VHErtO9CEs
3/3 For mEPSCs in neurons cultured from GluA2 KO mice, NASPM, unlike spermine, blocked all outward currents. Thus, NASPM-dependent full rectification offers a clear advantage over use of spermine and should allow a more quantitative assessment of the CP-AMPAR content of synapses.
2/3 Starting from the question “Can we do better than 100 μM intracellular spermine?”, we examined other blockers and found that 100 μM intracellular NASPM produces complete block of outward currents through CP-AMPARs – regardless of their co-assembly with auxiliary subunits.
1/3 New at @biorxiv_neursci, our @IanDCoombs-led study of CP-AMPAR block.
https://t.co/fwvNQpcaKK
Spermine-dependent rectification is widely used to reveal CP-AMPARs, but auxiliary proteins alter spermine block/permeation, limiting its utility as a tool for their detection.
When those figures just need those final adjustments...
At last, the missing 'Select Same' magic that kept me going back to Illustrator comes to Affinity Designer from @affinitybyserif.
Fascinating new study from the Greger Lab @MRC_LMB –
Gating transitions and modulation of a hetero-octameric AMPA glutamate receptor
"...GluA1/2 receptor assembled with both TARP-γ8 and CNIH2... in both resting and active states..."
https://t.co/xTfHWcYsNy
Fascinating new study on Shisa7 by Wei Lu and colleagues.
Han et al - Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions
"...a new dimension for understanding and reanalysis of GABAAR function and pharmacology"
https://t.co/HDlcBoR6H7
New online at @biorxiv_neursci, our @uclnpp study of homomeric Q/R edited AMPA-type glutamate receptors: desensitized but not closed! Down to the hard work and persistence of @IanDCoombs.
https://t.co/vasfIW1Daa
Now online at @SfNJournals eNeuro Early Release, our @uclnpp/@UCL_ICH study on AMPA-type glutamate receptors in a mouse model of juvenile #BattenDisease. All thanks to the hard work of DS.
https://t.co/8O64iDHgZd