Marko Loncarevic

[Johns Hopkins Psychedelic Research Center @JHPsychedelics]

At the College on Problems of Drug Dependence (CPDD) 86th Annual Scientific Meeting in Montreal, Quebec, post-doc Dr. Jérémie Richard (@JRichardPhD) presented on differing patterns of change in alcohol and drug use behaviors among participants who had a psilocybin experience outside of a laboratory setting.

The findings were indicative of improvements in these symptoms for most participants, although a small group indicated a pattern of worsening alcohol and drug use after psilocybin use. These have implications for the use of psilocybin in clinical trials, including the importance of pre-treatment screening, adequate preparation and the role of psychological support during psilocybin dosing sessions.

More details are available at https://t.co/3CaDx7jJyU

[Nicholas Fabiano, MD @NTFabiano]

Coffee changes connectivity in the brain.

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[Nicholas Fabiano, MD @NTFabiano]

There are six biotypes of depression.

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[Marko Loncarevic @m_loncarevic]

https://t.co/h61V1LuKT6

[Johns Hopkins Psychedelic Research Center @JHPsychedelics]

We just launched a new psilocybin study for PTSD!

We are seeking individuals with Post Traumatic Stress Disorder who are at least 21 years of age to take part in a research study. This study will take place in Baltimore, MD and will investigate whether psilocybin can improve quality of life in those diagnosed with PTSD.

Learn more and apply at https://t.co/8WSrERjlyb

[Robin Carhart-Harris @RCarhartHarris]

Psilocybin-therapy for chronic pain (fibromyalgia syndrome): @juliabornemann and @jamesbclose are heroes (among heroes). You'll be excited to learn this trial is now complete & the team are working on the first paper ("all in good time..."): https://t.co/d2HiWrYROz

[Johns Hopkins Psychedelic Research Center @JHPsychedelics]

Do you like listening to music? We are seeking individuals to participate in a research study looking at the effects of musical playlists on emotions, well-being, and brain function. Volunteers must be medically and psychiatrically healthy and must be able to travel to Johns Hopkins for up to 6 study visits. To learn more and apply, visit
https://t.co/dvAcDr9L1E

[Taylor Sterling @FatherMcKennaa]

Classic psychedelics like LSD, shrooms, DMT, & mescaline are non-addictive & impossible to overdose on. That's not why they're dangerous.

The danger is they open you up. You question your culture, your beliefs, your purpose. If you're content in life, don't try psychedelics.

[Brian Barnett @BrianBarnettMD]

Worst part of psychedelic trials is saying no to potential participants. We receive 100s of calls from ineligible folks who feel they have no options. When I discuss TMS, ECT, ketamine, MAOIs, trauma therapy, etc many are totally surprised. Makes me sad for them and psychiatry.

[Matthew W. Johnson @Drug_Researcher]

Excellent description of HPPD from psychedelics, as experienced by the fascinating journalist Andrew Callaghan, interviewed by @lexfridman . We will no doubt see HPPD cases with medical psychedelics. Likely rare but a real risk. It needs more attention. https://t.co/YP08KkgiA5

[Tim Ferriss @tferriss]

Tony Robbins believes that, in a lowered emotional state, we only see the problems, not solutions.

Let’s say you wake up feeling tired and overwhelmed. You sit down to brainstorm strategies to solve your issues, but it comes to naught, and you feel even worse afterward. This is because you started in a negative state, then attempted strategy but didn’t succeed (due to tunnel vision on the problems), and then likely told yourself self-defeating stories (e.g., “I always do this. Why am I so wound up I can’t even think straight?”).

To fix this, he encourages you to “prime” your state first. The biochemistry will help you proactively tell yourself an enabling story. Only then do you think on strategy, as you’ll see the options instead of dead ends.

“Priming” my state is often as simple as doing 5 to 10 push-ups or getting 20 minutes of sun exposure.

I often ask myself, “Is this really a problem I need to think my way out of? Or is it possible I just need to fix my biochemistry?” I’ve wasted a lot of time journaling on “problems” when I just needed to eat breakfast sooner, do 10 push-ups, or get an extra hour of sleep.

Sometimes, you think you have to figure out your life’s purpose, but you really just need some macadamia nuts and a cold fucking shower.

[Andrew D. Huberman, Ph.D. @hubermanlab]

New Huberman Lab podcast out now:
MASTERING GROWTH MINDSET•
•Beliefs About Effort Shape Outcome
•Make Stress Performance Enhancing
•Advice for Teachers & Students
•Adolescence Shapes Work Ethic
•Neuroplasticity & Growth Mindset
•Implementation
https://t.co/mdeIqyFjWQ

[Andrew D. Huberman, Ph.D. @hubermanlab]

All the Instagram users getting a real world experience of dopamine reward prediction error right now.

[Julie Holland, MD @BellevueDoc]

Altered states and social bonds: Effects of MDMA and serotonergic psychedelics on social behavior as a mechanism underlying substance-assisted therapy
https://t.co/FKHD0eOp8o

[Brandon Weiss @BWe1ss]

Wonderful to have been a part of this new study 🔭 finding evidence of expectancy predicting dep response in the Escitalopram tx arm, but *Not* the Psilocybin Therapy arm

Led by @psybalazs & @RCarhartHarris @DavidErritzoe @_fernando_rosas @ProfDavidNutt

https://t.co/9liymcJgDO

[Andrew Steinberg @DrSteinberg_Uro]

Lower testosterone levels are associated with higher risk of death in men https://t.co/Lh4n8bv3vj

[Andrew Steinberg @DrSteinberg_Uro]

🔬 New Study Alert: Understanding TRTs Role in Men's Mood 🧠

Did you know low testosterone can affect your mood? A recent study (TRAVERSE Trial) explored how testosterone-replacement therapy (TRT) might help men with low testosterone levels who feel persistently down or depressed.

Key Takeaways:
👨‍⚕️ Participants: Men aged 45-80 with low testosterone levels and heart disease risk.
🔍 Focus: Examining if TRT improves mood and energy levels.
📊 Results: Significant mood and energy boost noted in many,

Remember, mental health is crucial at every age. If you're feeling down, it might be more than just a mood. Let's talk about how your testosterone levels could be playing a part.

#MensHealth #TestosteroneTherapy #MentalWellness #TRT

https://t.co/qSOfBFKJEw

[Dr. Rhonda Patrick @foundmyfitness]

NEW EPISODE WITH @PeterAttiaMD
Can we age more slowly and evade or forestall the diseases of aging?

In today’s episode, the brilliant @PeterAttiaMD equips us with some of his favorite strategies and tools designed to delay or potentially prevent cardiovascular disease, cancer, and Alzheimer’s disease, aiming to preserve health, longevity, and ultimately win the ‘centenarian olympics.’

TIMESTAMPS:
(00:08:02) What is cholesterol?
(00:15:03) Why ApoB is a superior predictor of cardiovascular disease over LDL particle number
(00:33:31) Whether there’s an ApoB level low enough that it’s impossible to die from atherosclerosis
(00:37:20) Which dietary factors increase ApoB
(00:51:04) Whether or not low LDL is a risk for cancer – and a variety of other surprising facts about LDL biology you really can’t find anywhere else
(00:56:52) How statins and other lipid-lowering pharmacotherapies work, including their side effects and costs
(01:23:51) Statin alternatives pros & cons: PCSK9 inhibitors, ezetimibe, & bempedoic acid
(01:36:35) How increased muscle mass helps achieve lower blood sugar levels – reducing overall mortality – and the potential for suboptimal glycemic control long before doctors identify it
(01:52:28) Peter’s 80% zone 2 / 20% VO2 max training protocol
(02:08:08) The danger of visceral fat and why it correlates with increased cancer risk
(02:12:03) Benefits & risks of aggressive cancer screening
(02:24:49) Recommended mammogram & ultrasound frequency for women
(02:31:41) Radiation from CT scans & mammograms
(02:37:27) Menopause (hormonal changes, hot flashes, sexual changes, & bone loss) & hormone replacement therapy
(02:59:57) How hormone replacement affects dementia, cancer, & heart disease risk in women
(03:05:35) Vitamin D: Sunlight vs. supplements & optimal levels
(03:23:01) Is it safe for a woman who’s 10 years post-menopause to do HRT?
(03:21:45) Why symptoms of low testosterone are often more important than the actual levels when deciding whether or not to go on TRT
(03:28:07) Why Peter’s recommended TRT dosing schedule differs from the standard
(03:37:00) Methods for lowering blood pressure: exercise, nitrates, hot tubs, & cocoa flavanols
(03:49:44) Peter’s exercise, sleep, nutrition, & alcohol routines for optimizing longevity

You can find Dr. Peter Attia's book "Outlive: The Science and Art of Longevity” here: https://t.co/J04aF5dO2e

Full episode available on YouTube and where ever podcasts can be downloaded:
https://t.co/pVHvW8F2Wp

[Alex | The Testosterone Consultant @TestoConsultant]

High T benefit:

Naturally high testosterone men have a FAR higher stress tolerance than lower T men and basically every woman on the planet.

It protects you against chronic cortisol elevation.

It's a superpower, in a sense.

[Andrew D. Huberman, Ph.D. @hubermanlab]

New Huberman Lab podcast out now:
HOW TO BUILD IMMENSE INNER STRENGTH w/David Goggins @davidgoggins
•Transmuting Trauma & Pain
•Mastering Your Inner Dialogue
•Taking on Mental Challenges
•Resetting Resolve Daily
•The Power of Confronting Darkness
https://t.co/xP4xcVWjWt