Matt McCormack

Ambo, Dad

[Psychiatry Excellence @psycheureka]

Autism is not simply a disorder of ‘social communication’

Its neurobiology extends across systems involved in salience, reward, executive function, sleep and sensory processing.

Here’s how these systems can help explain the very different clinical presentations seen in ASD. 🧵👇

[Matt McCormack @mackasmatt]

@jk_rowling Taken today.

[Matt McCormack @mackasmatt]

@deeceepee80 Harrison for Schultz, rest that Achilles. Had 12 tackles in the VFL.

[Matt McCormack @mackasmatt]

@CricketopiaCom Peshawar not Karachi.

[tern @1goodtern]

For the billionth time:

Most of the 'symptoms' of an infection (fever cough tiredness etc) are your body fighting the infection.

The later symptoms are the work of the actual pathogen… and they're the ones that your body is trying to prevent.

[Matt McCormack @mackasmatt]

@NUFC Felt like I read less information by clicking read more.

[Massimo @Rainmaker1973]

We wouldn’t be here if the universe were even slightly different.

This is what scientists call the fine-tuning problem.

The more we study the cosmos, the clearer it becomes: the physical laws of our universe are finely tuned – balanced precariously atop a hill.

If the strength of gravity were just a fraction weaker, galaxies wouldn’t form. If the strong nuclear force were slightly stronger, stars wouldn’t burn. If the expansion rate of the universe were off by one part in 10⁶⁰, matter would either collapse into a single point or spread so thin no stars could ever ignite.

[Roger Seheult, MD @RogerSeheult]

They planted 8000 trees in 4 mi.². You won’t believe what happened next.

[Brain Inflammation Collaborative @BrainInflCollab]

An Epstein-Barr Virus (EBV) infection increases your susceptibility to developing multiple sclerosis (MS), among other chronic conditions such as:
- Celiac disease
- Long COVID
- Sjogren's
- ME/CFS
- Lupus
- POTS

A new study might have discovered why (at least for MS)...🧵

[Brain Inflammation Collaborative @BrainInflCollab]

Data suggest there is a broken ion channel on the surface of white blood cells in patients with (1):
- Long COVID
- ME/CFS

New evidence suggests it can be fixed.

Here is how...🧵

[Dr. Sean Mullen @drseanmullen]

179 experts. 28 countries. 1 message:

Long COVID is real, multi-systemic, and devastating. It affects over 400 million people. And we're not prepared.

New global consensus just dropped.

https://t.co/U8nsX8q360

🧵

1.
Long COVID is not "just fatigue." It’s organ damage, immune dysfunction, and neurological injury—even when tests look “normal.”
Consensus: routine labs often miss it. We need biomarker access. We need real diagnostics. Now.

2.
Functional impairment matters. Long COVID isn’t just about symptoms—it’s about how much harder life becomes even without them.
This redefines the disease. It’s invisible disability at scale.

3.
Consensus: Long COVID includes dysautonomia (POTS), mast cell activation (MCAS), mitochondrial dysfunction, endothelial damage, & more.
This isn’t one disease. It’s a syndrome of syndromes.

4.
PEM (post-exertional malaise) is real. Exercise isn’t always safe.
Consensus: “Graded exercise” can harm if POTS or PEM aren’t ruled out.
No more “just walk it off” advice from uninformed doctors.

5.
Most standard tests will come back normal. That doesn’t mean you’re fine.
Consensus: Advanced imaging, tilt tests, CPET, microclot detection, and mitochondrial function markers are needed—but rarely available.

6.
The kids aren’t okay.
Consensus: We must study how repeated infections affect kids’ brains, immune systems, hormones, and learning.
COVID is not “mild in children” if it leaves them cognitively impaired.

7.
Vaccines help—but they don’t prevent Long COVID.
Consensus: Some develop symptoms after vax. Some improve. Some get worse. We need research, not gaslighting.

8.
Mental health matters—but it doesn’t cause Long COVID.
Consensus: Psychological support can help—but this is NOT a psychiatric condition. It's physiological. And measurable.

9.
Consensus: clean indoor air reduces Long COVID.
Translation?
It’s still airborne.
If your school or workplace isn’t filtering air, they’re increasing risk of disability.

10.
Consensus: We need global investment in diagnostics, treatment, and workplace protections.
Governments cannot abandon public health because “the vibes are off.”

11.
The economy? Also infected.
Consensus: Long COVID is crushing productivity, deepening inequality, and draining healthcare systems.
Ignoring it is a policy failure.

12.
This isn’t over. Not even close.
We need trials.
We need funding.
We need prevention.
We need to listen to patients.
179 global experts agree.
Will your government?

[Massimo @Rainmaker1973]

Three new balls are generated after each one exits

[🎞️ ballzs77]
https://t.co/mTG72fWdtY

[Chicago Bulls @chicagobulls]

JOSH GIDDEY FOR THE WIN FROM HALF.

@CHSN__ | @joshgiddey

[The Heart @ZHeart11768530]

🟡 Left Bundle Branch Block

https://t.co/9k4znpVdnT
#CardioEd #Cardiology #EPeeps

[Brandon Luu, MD @BrandonLuuMD]

⏰ Your body’s metabolism follows a circadian rhythm—eating late throws it off.

In a 6-year study, those who ate most of their calories at dinner had:
⚠️ 2x higher risk of obesity
🩺 1.5x higher risk of metabolic syndrome
🍔 1.6x higher risk of fatty liver disease

🧵 1/9

[Brandon Luu, MD @BrandonLuuMD]

Disrupted sleep and circadian rhythms are deeply intertwined with mental health.

They don’t just reflect mental illness—they can drive it. And psychiatric symptoms further disrupt sleep.

Restoring circadian health could be a powerful treatment 🧵 1/12

[Ben Smith @bensmithlive]

Depression isn't a mental health disorder—it's a metabolic disease.

Antidepressants fail millions because they target brain chemistry—not the cellular metabolism where the real problem lies.

Here's why depression is a metabolic problem (and how to fix it): 🧵

[Brandon Luu, MD @BrandonLuuMD]

Lifestyle is a stronger predictor of aging and mortality than genetics.

A new Nature study of ~500,000 people found:
🎯 17% of mortality variation was linked to lifestyle (exposome).
🧬 <2% of was explained by genetics.

Here’s what you need to know 👇🧵 1/10

[IMCrit @IM_Crit_]

ICU Resuscitation Thoughts:

Every 2 y this time of the year I have to provide my hospital-employer w proof of ACLS recertification. I usually take an on-line course which I finish in a few hours. Sadly, this biennial ritual is also a reminder that we keep following the same #CPR

[Space Koala @SpaceKoala]

I will tolerate recurrent laryngeal nerve slander no longer! It's actually the result of several elegant solutions to difficult problems in embryology, and the length is a non-issue. A 🧵 1/13