Manuel J. Carrasco

Bioengineering Ph.D student. Co-Founder AexeRNA Inc. for mRNA therapeutics. Bold philanthropist existentialist scientist. COVID19 mRNA vaccines.🇺🇸 🇵🇪🧬😼

[News from Science @NewsfromScience]

A new generation of lipid nanoparticles could lead to better mRNA vaccines for #COVID19 and other diseases. https://t.co/IglZHy1nIO

[Manuel J. Carrasco @manyucch]

@ross_stalker @MyasthenicT1D @thestephaniewat @JeanRees10 @undergroundsar4 Thanks for answering questions and clarify scientic doubts very accurately.

[Manuel J. Carrasco @manyucch]

Presenting Poster in the Biomedical Engineering Society - 2021 in Florida, US.
Link to the poster website:
https://t.co/BL1WSc9Dv5
Link to the PDF poster:
https://t.co/Uhf3GAMBGM

[SPBBC @Bioinfo_Peru]

🇵🇪Simposio del Bicentenario🇵🇪
Presentación Estudiantil #3
Manuel Carrasco presenta: "LNP ionization, charge, and ultrastructure influence mRNA Delivery Efficiency and Biodistribution in mRNA vaccines"
#bicentenario_bioinfo
@ConcytecPeru @ISCB_RSGPeru

[olivenews @olivenews]

mRNA脂質ナノ粒子のイオン化と構造特性は、筋肉内および血管内投与における発現に影響を与える
https://t.co/ubgHUwBBOi
負に帯電したLNPが多いほど、IM投与後の肝臓でmRNAのオフターゲット全身発現が高くなることを確認しました。

[The Lipid Chronicles @lipidchronicles]

Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration https://t.co/s5OLt8eaus (@CommsBio)

[Manuel J. Carrasco @manyucch]

@JeanRees10 @undergroundsar4 In general, it has been reported and estimated that several billions to trillion of nanoparticles/ml. I cant tell how many exactly in the current covid vaccines.

[Manuel J. Carrasco @manyucch]

@JeanRees10 @undergroundsar4 Hello. Sorry for the delayed response. I can point out some data if you clarify what type of measurements are you looking for. Thank you ! And thank you again for getting interested in our research :)

[Manuel J. Carrasco @manyucch]

Lipid C24 on sale was designed in our lab and tested for a new COVID19 vaccine.
#AexeRNA #COVID19 #GMU

https://t.co/up0apygaWu

[Manuel J. Carrasco @manyucch]

Our COVID19 vaccine paper is out as preprint #vaccine #COVID19

[Research Square Covid-19 Preprints @RS_COVID19]

Novel lipid nanoparticle provides potent SARS-CoV-2 mRNA vaccine at low dose with low local reactogenicity, high thermostability and limited systemic biodistribution #covid https://t.co/cIDVr0ut1h

[Manuel J. Carrasco @manyucch]

New vaccine batch based its design from our schematic in Figure 1 Buschmann et al. 2021. Thanks Paul Klinger! @Almoturg

[Microchip Makes @MicrochipMakes]

Paul Klinger's ATtiny1617-based badge blinks the RNA sequence of the Moderna and Pfizer vaccines: https://t.co/Iw6EWL44cJ

[Manuel J. Carrasco @manyucch]

New vaccine batch based its design from our schematic in Figure 1 Buschmann et al. 2021. Thanks Paul Klinger!

[Microchip Makes @MicrochipMakes]

Paul Klinger's ATtiny1617-based badge blinks the RNA sequence of the Moderna and Pfizer vaccines: https://t.co/Iw6EWL44cJ

[Manuel J. Carrasco @manyucch]

@JeanRees10 @undergroundsar4 Thanks for getting interested in our paper :)

[Communications Biology @CommsBio]

Carrasco et al. describe their method for predicting the pKa of lipid nanoparticles based on the structure of the ionizable lipid and show how it can be used to limit off-target systemic distribution and expression for mRNA LNP vaccines. https://t.co/zINBIBJcOr

[Manuel J. Carrasco @manyucch]

First research paper in our lab at George Mason University. #Carrascoetal2021
https://t.co/9sb0IkdmNp
https://t.co/uV4eGWf2ly
#research #science #mRNA
https://t.co/VGiDsKL1ad

[Manuel J. Carrasco @manyucch]

Pt. 5 Muchas sustancias generan anticuerpos y porque generen anticuerpos no significa que va a haber protección o va a funcionar en la manera adecuada. Costos.. optimizaciones.. preguntemos.
#Manolo #SARSCoV2 #farvet #COVID19 #vaccines @FSagasti @ConcytecPeru

[Manuel J. Carrasco @manyucch]

Pt. 4 La ciencia es exacta, y tiene procedimientos y métodos. Debería haber mas regulaciones y ensayos comparativos con las actuales vacunas aprobadas por el FDA.
#Manolo #SARSCoV2 #farvet #COVID19 #vaccines @FSagasti @ConcytecPeru

[Manuel J. Carrasco @manyucch]

Pt.3 @presidenciaperu deberia pedir mas información y resultados sobre la vacuna peruana, asi compartir con todos y seguir apoyando antes de financiar. Todo con claridad
#Manolo #SARSCoV2 #farvet #COVID19 #vaccines @FSagasti @ConcytecPeru

[Manuel J. Carrasco @manyucch]

Pt.2 He visto que hay mucho apoyo por sacar una vacuna eficiente proveniente del Peru. Me pregunto que data utilizaron para que la gente confíe en ella y no en otras vacunas. Que les dijeron? " si funciona " y ya?
#Manolo #SARSCoV2 #farvet #vaccines @FSagasti @ConcytecPeru

[Manuel J. Carrasco @manyucch]

Pt.1 #Manolo dijo que si habia vacunado a su familia, entre otros.... contra #SARSCoV2 (solo con data de anticuerpos y pseudoneutralizacion). Toxicidad? Targeting y activación de células del sistema inmune? Resultados del challenge? #farvet #vaccines @FSagasti @ConcytecPeru