Marc Gastonguay MRG

Chairman, Board of Directors at Metrum Research Group

[Marc Gastonguay MRG @marcg_MetrumRG]

With great pleasure, I am handing over the leadership reins of @MetrumRG to @adprmichelle. The company’s future is bright and our mission to defeat disease remains.

[MetrumRG @MetrumRG]

MetrumRG’s co-founder Marc Gastonguay shares his reflections on today’s company announcement–read it here: https://t.co/ZOyFzVodHn

[Marc Gastonguay MRG @marcg_MetrumRG]

@MetrumRG Thank you to ISoP and the nominators for this great honor. I believe this award is a reflection of the meaningful impact made by our entire mission-driven team at MetrumRG. I am so grateful to each one of them for the important work they do every day.

[MetrumRG @MetrumRG]

Congratulations Dr. Marc Gastonguay, recipient of the 2022 ISoP Leadership Award! Marc is a dedicated, service-driven leader of our company and our community. Well done, Marc!

[MetrumRG @MetrumRG]

Join our team at MetrumRG! Check out our job posting for the Vice President of Product: https://t.co/i1RMyOkA1O

[MetrumRG @MetrumRG]

MetrumRG is proud to be a founding sponsor of the recently launched CT chapter of Women In Bio!
https://t.co/8Oh6OEXG7d

[Marc Gastonguay MRG @marcg_MetrumRG]

Sharing my heartfelt gratitude for each and every member of the team @MetrumRG. Thank you for your dedication, efforts, and amazing contributions to our mission. #EmployeeAppreciationDay

[Marc Gastonguay MRG @marcg_MetrumRG]

Thank you @SDuffull for the opportunity to participate in this exciting seminar series! I enjoyed the thought-provoking interaction with faculty and students. In case anyone is interested, the presentation is openly available here: https://t.co/iQ2uI2tPDq

[Stephen Duffull @SDuffull]

A fantastic talk from Marc @marcg_MetrumRG on Pharmacometrics and health economics at our Te AO International seminar series. @HeshamAlSallami @wrida959 (A silver lining of Covid [we never did this series before lockdown])

[Marc Gastonguay MRG @marcg_MetrumRG]

Another one of several #openscience examples at #ACoP11! Riggs et al implemented the work with the #opensource modeling tool @mrgsolve, and shared the modeling and simulation source code: https://t.co/LYVPpCo6F9

[MetrumRG @MetrumRG]

Today at #ACOP11 don't miss Matthew Riggs' poster #Tue-055 at 12:30 PM EDT. Learn how our Bone Health and Mineral Model was extended to explore hyperphosphatemia induced by FGFR inhibition.

[Marc Gastonguay MRG @marcg_MetrumRG]

Statistical M&S Scientists - If you're seeking a challenging and fulfilling career, join our team's efforts to fight diseases and grow the science of biomedical modeling and simulation. #Statistics #openscience #opensource https://t.co/WxmvDemEDG

[MetrumRG @MetrumRG]

Happy to support StanCon again this year! Lots of great sessions to check out today. Have a great meeting, everyone! @mcmc_stan https://t.co/VBDhWv44y5

[Ya-Feng Wen @YaFengWen]

Check out our very first issue of the ISoP Student Newsletter to learn more about the upcoming webinars, events, interns/post-doc positions!

Shout out to all the efforts from the Commincation team to make it happen! Thank you @zaid_temrikar @anne8rete @JaberTaz @ShenCheng20

[Kyle Baron @kylebtwin]

New in mrgsolve 0.10.4: $NMEXT that works like $NMXML, but reads the nonmem root.ext file rather than root.xml. This speeds up mread when the model was estimated with METHOD=BAYES. Thanks @thwaterhouse for collaborating on this feature. https://t.co/G7NhIHpgr2

[Marc Gastonguay MRG @marcg_MetrumRG]

I’m grateful to Roger for his impactful and pioneering contributions to our field. His 1990 AMIA workshop was my first exposure to mixed effects models & Bayesian estimation - opened my eyes to the tremendous potential for mathematical modeling in clinical pharmacology.

[MetrumRG @MetrumRG]

We’re looking for a senior level Translational and Systems Pharmacology M&S Scientist to join our team! Apply today at https://t.co/IY5M8jVJQl

[MetrumRG @MetrumRG]

We're hiring a Quality Manager! Join us in our mission to defeat diseases! https://t.co/Nt6i5zXhjB

[Marc Gastonguay MRG @marcg_MetrumRG]

@theRealDrWeber It may have been valuable to explore the decision process via simulation at the time when criteria were set. Include sim scenarios such as the border case you described. What additional evidence would be required to override original criteria?

[Marc Gastonguay MRG @marcg_MetrumRG]

@MikeKSmith @MetrumRG Sure. We'll capture key points in a blog next week.

[Marc Gastonguay MRG @marcg_MetrumRG]

@vijay_ivaturi @ISOP1 Good point @vijay_ivaturi . A shift in standards for publication in medical literature would help. We can contribute by presenting alternative measures of evidence (e.g. posterior predictive probability) when we have the opportunity.

[Marc Gastonguay MRG @marcg_MetrumRG]

Calling on pharma/biotech modeling and simulation scientists @ISOP1 to sign the petition, or better yet, abandon the use statistical significance in your work. #PMX #QSP #stats

[Andrew Gelman et al. @StatModeling]

“Abandon / Retire Statistical Significance”: Your chance to sign a petition! https://t.co/jJyXqVfT2B

[Marc Gastonguay MRG @marcg_MetrumRG]

Agreed! Trying to make inferences about exposure-response relationships from a study with single dose level (exposure is an outcome) is a similarly atrocious approach; risk of confusing disease severity for pharmacodynamics.

[Frank Harrell @f2harrell]

Using tertiles to analyze biomarkers is an absolutely atrocious approach, confusing demography for physiology. @DanMarkMD