Marcos Nava

For science!!!! & the metric system!

[Marcos Nava @marcosalioth]

@CFE_Contigo reporte urgente, sin suministro contrato 533090104720, Mazatlan, Sinaloa

[Bryan Johnson @bryan_johnson]

Three exciting longevity results came back from my first dose of mushrooms: >35% decrease in inflammation, a deeply relaxed state and neuroprotective effects.

Inflammation (hsCRP)
My systematic inflammation levels dropped from elite to undetectable. This decrease is significant, aligning with clinical reports of reduced inflammation markers (CRP, TNF-alpha, and IL6) seven days post high dose psilocybin.

+ pre-mushrooms: 0.23mg/dL
+ post-mushrooms: < detection limit 0.15mg/dL
+ >35% decrease

Deep low stress state (HPA Axis)
My cortisol and DHEA-S dropped by 42% and 45%, respectively, suggesting a profound inhibition of the Hypothalamus-Pituitary-Adrenal (HPA) axis, which corresponds with the "after-glow" effect.

+ DHEA-S: 287µg/dL to 157 µg/dL
+ morning cortisol: 10.3 µg/dL to 5.9 µg/dL

While cortisol spikes acutely during the trip, the post-session drop indicates a shift from sympathetic to parasympathetic dominance. This aligns with my sustained relaxed and joyful state.

Neuroprotection (Estradiol)
Estradiol increased 3x (11.3 to 36 pg/ml). This may be due to peripheral activation of 5HT2A receptors stimulating aromatase activity, the enzyme that converts testosterone to estradiol.

A study has shown 5HT2A stimulation in human placental cells can drive aromatase gene expression and activity. My testosterone levels remained unchanged, indicating my body compensated for the minor conversion to estradiol.

The increase is within the normal male range and is generally positive, as estradiol provides anti-inflammatory, neuroprotective and cardiovascular protective effects.

Conclusion
Taken together, these data suggest that a single high dose psilocybin experience can transiently push my biology into a low inflammation, low stress configuration that is theoretically favorable for longevity.

Measurement window: 4 days before vs. 5 days post-dose

[Marcos Nava @marcosalioth]

@elonmusk u should build a mechanical wristwatch as a hobby project: engineered with Falcon/Starship materials, spacecraft-level precision, &amp; durability that survives atmospheric re-entry. Something that makes AP, Rolex &amp; Cartier look overpriced toys compared 2 real engineering.

[Marcos Nava @marcosalioth]

@dw_espanol He literally said in a Piers Morgan interview weeks before that he wanted to visit the White House and meet Donald Trump. And now DW acts like he was dragged there as some kind of propaganda puppet? Seriously, what’s going on with their editors?

[Elon Musk @elonmusk]

The Sun is 99.8% of all mass in our solar system.

Even if you somehow burned Jupiter and everything that is not the Sun in a fusion reactor, the Sun would still round up to 100% of all energy.

The Sun is all that matters long-term.

[Marcos Nava @marcosalioth]

@elonmusk impressive image, many people are becoming enviously evil as the photo become popular.

[Marcos Nava @marcosalioth]

@bryan_johnson Super cool diet! do you use probiotics? any specific strain? collagen peptides are from beef or any specific animal? the origin was grain fed free?

[Cayetana Álvarez de Toledo @cayetanaAT]

La presidenta @Claudiashein

Exige disculpas a España por los muertos de hace 500 años cuando debería ofrecerlas ella por los mexicanos que mueren hoy.

Carlos Manzo, joven y valiente alcalde de Uruapan, última víctima de la violencia que desangra México.

Descanse en paz.

[Marcos Nava @marcosalioth]

@DavidSacks You are the best!!! Big fan!

[Marcos Nava @marcosalioth]

@DavidSacks ChatGPT is infected with woke virus!

[Marcos Nava @marcosalioth]

@dw_espanol Woke virus

[Marcos Nava @marcosalioth]

@uncledoomer Clever right???? He is cool!

[Bryan Johnson @bryan_johnson]

5g of magic mushrooms https://t.co/vYDQ7egWAJ

[Marcos Nava @marcosalioth]

@elonmusk I’m pretty sure ChatGPT is infected with woke virus!!! I had a big discussion today with it. It doesn’t have problems having tampons in boys restrooms.

[Marcos Nava @marcosalioth]

@bryan_johnson @elonmusk Congrats!!! Now you are wiser!

[Marcos Nava @marcosalioth]

@mdantus @SharkTankMx @paradiseshopmx @startupmexico Mil disculpas, Lorena Llerandi.

[Marcos Nava @marcosalioth]

@mdantus te sigo desde @SharkTankMx y @paradiseshopmx de una ponencia en Monterrey. A través de @startupmexico traté contactarte. Paola L se puso en contacto, sus cuestionamientos vía mail parecen más para piratear ideas que para entender el proyecto. No da buena espina #startups

[Marcos Nava @marcosalioth]

@PauOropeza @SChecoPerez Mejor “Vamos Checo!”

[Marcos Nava @marcosalioth]

@elonmusk please manage a F1 Team!!! We want to see F1 cars to another level even if they are hybrid. Would be super interesting and challenging with a low budget team (your expertise). 🏎💨💨💨

[Marcos Nava @marcosalioth]

@avis you have a big customer line waiting in San Antonio Airport and only one person to service.