Marcus

Senior Data Scientist at Relation Therapeutics | Hanc marginis exiguitās nōn caperet

[Stephanie Gaglione @Steph_Gaglione]

Thrilled to share our preprint! We introduce TCRAFT, a method to assemble tens of thousands of TCRs at <$1 each, unlocking high-throughput functional TCR screening from single-cell data.
🧵@kochinstitute @MEBirnbaum @MITChemE @MIT

https://t.co/zifGBP4p7k

[Paddington @paddingtonbear]

Nothing brightens a day quite like doing something kind for another person.

[Aleksejs Sazonovs @alehins]

When Anaconda demand that you buy a per-user enterprise license for your HPC

[Marcus @marcus_NJ]

@alehins NP level xmas problem

[Bradley Harris @Bradleyomics]

Thrilled to travelling to #ASHG2024 today! If you want to hear about how we can use large scale single cell RNA sequencing to better understand susceptibility to common complex diseases - drop by my talk on Wednesday!

[Marcus @marcus_NJ]

Someone clearly removed HLA due to complex LD structure in the Cambridge plot

[Megan Gozzard @PhDood1es]

What geneticists fear the most: The Cambridge Plot.

[Marcus @marcus_NJ]

@alehins That's what he won the Nobel for right?

[Marcus @marcus_NJ]

@alehins is that equivalent to a 10 sample MR

[Marcus @marcus_NJ]

@alehins Wow, they're going to put the pints on offer too alongside the renovation?!

[Aleksejs Sazonovs @alehins]

I’d love to read the reaction to this on the Cell editorial slack

[Marcus @marcus_NJ]

Where's Selena Gomez and Richard Thaler when you need them...

[Nate Silver @NateSilver538]

And P.S. you're probably going to have to get used to this. This market basically implies that the forecast is likely only going to be 60/40 in one direction or another by Election Day.

https://t.co/YvikPMSTPo

[Marcus @marcus_NJ]

Having been previously in this position with @anderson_carl and @FachalLaura, I can fully recommend it to those wanting to expand skillset, work on fascinating multi-omic datasets and be surrounded by a really motivated and smart team!
https://t.co/JiBPsAFy9a

[Marcus @marcus_NJ]

@alehins *hatere

[Marcus @marcus_NJ]

@alehins "..."We didn't consider HLA due to its complex LD pattern leading to limited fine-mapping insights"

[Open Targets @OpenTargets]

On #WorldIBDDay, Open Targets project lead @anderson_carl introduces our most ambitious project yet: @OpenIBD!

[Open Targets @OpenTargets]

📣Introducing Open-IBD — our most ambitious project yet!

@OpenIBD will bring together genomics and immunology experts, gastroenterologists, and patients from across the UK to identify new and personalised ways to predict, monitor, and treat inflammatory bowel disease

[Marcus @marcus_NJ]

@alehins No option for B) modified by C)?
What a garbage poll

[Marcus @marcus_NJ]

@alehins People will post stuff like this on twitter and then just post the hla region to taunt you :( Bet you don't even LD prune the hits

[Aleksejs Sazonovs @alehins]

.@FachalLaura rocking the room and casually announcing doubling the number of IBD associated signals, 500 candidate effector genes and 270 potentially causal proteins #ECCO24 #ECCO2024

[Marcus @marcus_NJ]

@alehins Have you tried squinting your eyes while looking at the individual genotype calls