Josh Marn

Baseball pitching, and catching Business=Oncology professional, leader, and motivator. purpose= loving husband and father.

[Brooklyn Marn '25 @brooklynmarn]

🔥BIG NEWS 🔥Excited to share that I am entering in the transfer portal‼️Can’t wait to make an impact at my future home. Thank you Ole Miss🫶
@ImYouthSoccer @ImCollegeSoccer @TopDrawerSoccer @NCAASoccer @247SportsPortal @TransferPortal @transferportal @TheSoccerWire @TopPreps

[Josh Marn @Marn220]

@TheDailyGold @Sorenthek @jameshenryand @Brien_Lundin @SeanBrodrick My strategy plan!

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[Dr Rishabh Jain @DrRishabhOnco]

💧 Not all bladder cancer patients need adjuvant IO!

In IMvigor011 (NEJM 2025), adjuvant atezolizumab was given only to patients with ctDNA positivity after cystectomy 🧬

🧪 Trial design:
•MIBC pts post-cystectomy → serial ctDNA monitoring (Signatera)
•ctDNA ➕ randomized 2 : 1 → Atezolizumab 🆚 Placebo
•ctDNA ➖ just observed 👀

📊 Results (ctDNA ➕ cohort):
•🕒 DFS: 9.9 mo vs 4.8 mo → HR 0.64 (P = 0.005)
•❤️ OS: 32.8 mo vs 21.1 mo → HR 0.59 (P = 0.01)
•⚠️ Grade 3-4 AEs: 28 % vs 22 % (fatal 2 % vs 0 %)

🌿 ctDNA ➖ cohort: DFS 95 % at 1 yr & 88 % at 2 yrs — safely spared adjuvant therapy 🙌

💡 Takeaway:
First phase III trial showing OS benefit with adjuvant IO guided by ctDNA in MIBC!
Precision-based adjuvant era is here 🚀

#OncoTwitter #ESMO25 #BladderCancer #Immunotherapy
@OncoAlert @myesmo @esmo_open @ASCO @NEJM

📚 Powles T et al. New Engl J Med. 2025
DOI: https://t.co/HsQDMl8ydD

[NEJM @NEJM]

Presented at #ESMO25:

In muscle-invasive bladder cancer, ctDNA-guided atezolizumab led to longer disease-free survival (9.9 vs. 4.8 months), as well as to longer overall survival (32.8 vs. 21.1 months), than placebo among ctDNA-positive patients. Full IMvigor011 phase 3 trial results: https://t.co/nbCPzF4Pxy

@myESMO

[Ole Miss Soccer @OleMissSoccer]

B Money💸💸

#HottyToddy

[Tom Powles @tompowles1]

In the future we won’t rely on pathology at surgery +/- luck to select patients for adjuvant treatment across cancers. Instead, the identification of residual disease by ctDNA/other biomarkers will be used. These data are a step towards that goal IMO. https://t.co/dPqlvr2rnV

[Ole Miss Soccer @OleMissSoccer]

Top shelf for your first career collegiate goal 🤯

@brooklynmarn | #HottyToddy

[Ole Miss Soccer @OleMissSoccer]

𝑺𝒕𝒂𝒓𝒕𝒊𝒏𝒈 𝑿𝑰

#HottyToddy

[Ole Miss Soccer @OleMissSoccer]

4+4= 🎱

#HottyToddy

[Maddox Marn @MaddoxMarn]

Finished up the UAA finals here are some highlights @UANextBHoops @RiseCircuit @BVSW_Hoops @GradyMajors @AYSABasketball @Coach_MBright @KevinMoses38 @PrepHoopsKS @TopPreps @RL_HoopsKS

[STA Saints Girls Soccer @stasaints_GSCR]

#BelieVeandAchieVe

[Brooklyn Marn '25 @brooklynmarn]

👀👀who's ready??
@stasaints_GSCR @HSSoccerKC @ImYouthSoccer @MaxPreps @810varsity @SSN_NCAASoccer @UnitedCoaches @KSHSAA @SpectrumNewsKC @metrosports_mk @TopDrawerSoccer @ImCollegeSoccer @GoAquinasSaints
#StateChamps

[STA Saints Girls Soccer @stasaints_GSCR]

@brooklynmarn takes down Omar in sudden death to advance to tonight's final at halftime of the Saints vs Thunder state semifinal FB game. She will take on the Thunder representative for *FREE* @ChickfilA for a year!! Let's go B!!

[Josh Marn @Marn220]

@NTebelak @StrengthDebates PWO are gone with roster limits everyone will be on a scholarship/NIL.

[Ole Miss Soccer @OleMissSoccer]

Culture, Traditions, People!

[Ole Miss Soccer @OleMissSoccer]

𝙒𝙚𝙡𝙘𝙤𝙢𝙚 𝙩𝙤 𝙩𝙝𝙚 𝙎𝙞𝙥: @brooklynmarn!

#HottyToddy x #BUILD

[Brooklyn Marn '25 @brooklynmarn]

🫣 🫣 who's ready??
@stasaints_GSCR @HSSoccerKC @ImYouthSoccer @MaxPreps @810varsity @SSN_NCAASoccer @UnitedCoaches @KSHSAA @SpectrumNewsKC @metrosports_mk @TopDrawerSoccer @PrepSoccer @GoAquinasSaints @SoccerMomInt @ImCollegeSoccer
#StateChamps

[Kansas Rush GA 06/07 @ksrushga0607]

2nd game of the weekend against Salvo SC! Right now up 2-1. Brooklyn w both goals!

[Kansas Rush GA 06/07 @ksrushga0607]

Goal Brooklyn M 1-2… Let’s go!

[Josh Marn @Marn220]

@missyMmcbeth These same people are concerned with creatine as well. Any lift can be dangerous if done incorrectly, just as any supplement can be dangerous if taken incorrectly. Most Drs. and Parents have very limited knowledge of weight training for performance.