Seymore Glass, MD

Cytopathologist in Texas.

[Seymore Glass, MD @martinwpath]

Gliosarcoma- Biphasic variant of glioblastoma with alternating glial and mesenchymal differentiation. Tumors have traditional features of GBM including palisading necrosis, microvascular proliferation, and high mitotic rate with additional sarcomatoid features. WHO grade IV.

[Seymore Glass, MD @martinwpath]

@dmyers86 Also neurofibromas with atypia in NF1 patients!

[Seymore Glass, MD @martinwpath]

Firbroepithelioma of Pinkus: premalignant lesion composed of interconnected and branching strands of basaloid cells embedded in a loose fibrovascular stroma. Extends from epidermis to dermis.

[Seymore Glass, MD @martinwpath]

Lymphangioma: large lymphatic channels in loose connective tissue with associated lymphoid aggregates. Usually well circumscribed with focal cystic formation. May be due to lymphovascular malformation. CD31/CD34/D2-40 (+).

[Seymore Glass, MD @martinwpath]

Cool to see hematopoiesis in the hyoid bone sent with this specimen! This entity may also have squamous lining or adjacent mucous type salivary glands.

[Seymore Glass, MD @martinwpath]

Excision of a thyroglossal duct cyst attached to hyoid bone. Micro showed multilocular cyst lined by respiratory epithelium with adjacent thyroid follicular tissue and inflammation.

[David Myers @dmyers86]

Salivary gland FNA. It doesn’t get any better than this.

[Seymore Glass, MD @martinwpath]

Post ET Myelofibrosis: This BMBX shows extreme hypercellularity with increased staghorn megakaryocytes in clusters. Reticulin showed MF3 fibrosis and diffuse collagen deposition.

[Seymore Glass, MD @martinwpath]

Splenectomy! Howell-Jolly bodies were another prominent finding. A splenectomy can decrease transfusion requirements.

[Seymore Glass, MD @martinwpath]

Blood smear from a patient with pyruvate kinase deficiency. Notable for echinocytes, polychromasia, and nRBCs. What is one way this patient was treated?

[Seymore Glass, MD @martinwpath]

Asteroid body in a lymph node with sarcoidosis.

[International Journal of Gynecological Pathology @IJGynP]

Use of Immunohistochemical Markers (HNF-1β, Napsin A, ER, CTH, and ASS1) to Distinguish Endometrial Clear Cell Carcinoma From Its Morphologic Mimics Including Arias-Stella Reaction by Dr. Jennifer X. Ji, et al. #GYNPath @ISGynP https://t.co/QDWso2ANk7

[Seymore Glass, MD @martinwpath]

@TeresaScordino this is a very helpful review, thank you!

[Seymore Glass, MD @martinwpath]

@TeamCaptainJohn @AABB I would have to look into that! I think a cross match would cover them in this hypothetical situation. And spoilers, but the transfusion went well haha.

[Seymore Glass, MD @martinwpath]

Transfusion medicine in the walking dead comics!

[Seymore Glass, MD @martinwpath]

@Pathonthewing I saw one last week with hyper cooling!

[Seymore Glass, MD @martinwpath]

The differential diagnosis included metastasis from other papillary carcinoma, ependymomas, papillary meningiomas, or normal choroid plexus.

[Seymore Glass, MD @martinwpath]

An adult female presented with a 4th ventricle mass and hydrocephalus. A biopsy was done with IOC (Pic 1/2). Sections showed a neoplasm with papillary architecture and fibrovascular cores lined by flat surface epithelium (Pic 3/4).

[Seymore Glass, MD @martinwpath]

A diagnosis of choroid plexus papilloma was rendered. This tumor is a WHO Grade 1 tumor most commonly in the ventricular system that may cause hydrocephalus (d/t obstruction or CSF overproduction), developmental delay, or epilepsy in children.