"Universal principles of cell population growth follow from local contact inhibition."
We just published an integrative experimental-mathematical approach to defining growth laws in the context of cell-cell interactions:
https://t.co/ieOv7inrrs
"Modelling cancer cell dormancy in mice: Heavy-tailed distributions and the role of cancer cell death in reactivation times" - Journal of Theoretical Biology.
With thanks to fantastic co-authors Nikos Sfakianakis and Dimitris Katsaounis
https://t.co/k3Fo7ohfHl
We just published a paper on drug-drug synergy and cell-cell interactions in combination therapy -- and we also assess single drug, combination, and sequential dosing. Such a fun collaboration!
Emond, Molec Sys Bio, 2026
https://t.co/dgz2KIC1dS
Joint work with Rena Emond, Aritro Nath, @ara_anderson, @AndreaBildLab!
1/ We are thrilled to share our latest research in Cancer Discovery! Grateful to all collaborators in this work, work led by Paul Mischel and Ben Werner, and to @drimrannoorani and @magnushaughey for driving this work! Special thanks: team eDyNAmic, UCL, @TheCrick , and CGC/CRUK
A very well-written and thoughtful piece from Itai Yanai and Martin Lercher, with a nice visual showing how we “trim the tree” of the process, for publication.
On a related note, I’d like to see more Math Onco papers show the discovery process within papers — e.g. the process of model selection!
Still at #ASTRO24? I’m presenting shortly the work of @keyurmedphys who developed an accurate model for toxicity-informed selection of proton therapy for prostate cancer. Join us in Room 145. @MGH_RI @HarvardRadOnc
Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️
https://t.co/Jgx79K3i3a @Gustavo_SFranca
Does cancer #evolution & intra-tumour heterogeneity predict long-term relapse? We tested the evolutionary paradigm in prostate cancer clinical trials with long follow-up, combining genomics with digital histopathology: https://t.co/76aiiba2eP
I’m delighted that our paper on the Multicellularity Long Term Evolution Experiment (MuLTEE) has, at long last, been published. This paper establishes the foundations of what I’d like to work on for the rest of my career. 1/25
Free, full access link: https://t.co/lWh33eHQrf
Happy to share our latest preprint. It’s started from failed attempts to find an effect of stroma on drug sensitivity in TNBC and made us revise our approach to chemo sensitivity assay, digging into tissue imaging&segmentation and some cool math modeling. https://t.co/6A7ZuewcJC
Postdoc position opening at City of Hope in ☀️☀️ California in #systemsbiology and #mathonco with a great interdisciplinary team
https://t.co/NaDipqQfj8
Our preprint about differences in somatic mutation accumulation in oligodendrocytes vs. neurons in the aging human brain is out! A beautiful collaboration between @ChrisAWalsh1 and @peter_j_park labs, co-led together with @luquette_j and @sarabiz86. https://t.co/BiyzEsBXqn