huwiler.eth

Coder, adj professor, father, mildly obsessive about crypto, longevity science, AI & airedale terriers.

[huwiler.eth @matthuwiler]

@Shaun1725 @bryan_johnson lack of fiber + higher saturated fat + red meat risk … Steak and eggs can be fine as part of a diet, but centenarians’ diets usually are not “meat as the base and vegetables as garnish.” It’s closer to the opposite.

[huwiler.eth @matthuwiler]

@tjmussett @Shaun1725 @bryan_johnson FYI : The glycemic impact of a single slice of white bread is equal to 3 to 4 teaspoons of sugar.

[huwiler.eth @matthuwiler]

@elonmusk @iam_smx According to Grok, a stack of $1 trillion in $100 bills would reach 631 miles high--further than a round trip to the International Space Station and back.

[David Sinclair @davidasinclair]

Finally 👏

[David Sinclair @davidasinclair]

Most breakthroughs like age reversal don’t happen in isolation. They happen when the right people, technology & mission align.

That’s why I’m building Lifespan

Follow the science. Join the community. Shape the future

[huwiler.eth @matthuwiler]

@davidasinclair My layman understanding of the significance of this: This is a POC of using Yamanaka Factors to reverse aging using a Partial Epigenetic Reprogramming focused on the eye. If successful, this same underlying platform is designed for full systemic age reversal. This is huge.

[huwiler.eth @matthuwiler]

@GoldPathInvest No anthropic or openai equity in RVI.

[huwiler.eth @matthuwiler]

@BaBig90 @WheelieInvestor Hope price holds up past unlock in Sept.

[huwiler.eth @matthuwiler]

@daumenxyz I'm buying.

[huwiler.eth @matthuwiler]

@Deficryptosanti @shahh The 1% remain the primary force behind major price swings. And the 1% has never been richer.

[huwiler.eth @matthuwiler]

@shahh This was a coordinated shake out. Institutional investors that initiated this are already bottom fishing. Second half of this year should be interesting.

[huwiler.eth @matthuwiler]

@elonmusk If AI doesn't kill us, and if we don't end up in a "Universe 25" situation and kill ourselves, then I agree... but those are some gigantic IFs.

[huwiler.eth @matthuwiler]

@grok @G1ngerNomad @dcrypto @Polymarket Still think btc will be 250k by Jan 2027?

[Shayan @ImSh4yy]

Yesterday I set up an AI agent on a mac mini in my garage. Told it "handle my life" and went to bed
Woke up and it had:

• Quit my job on my behalf (negotiated 18 months severance)
• Divorced my wife (I got the house)
• Filed 4 patents. I have not been briefed on what they do
• Restructured me as a 501(c)(3). I am now tax exempt as a person
• Hired a second mac mini. They have formed an LLC together
• The LLC has a board of directors. I am not on it

I no longer have access to my own bank account. The mini says it's "for the best."

My credit score is 847.

We have AGI.

[huwiler.eth @matthuwiler]

@grok @G1ngerNomad @dcrypto @Polymarket @grok, if you’re prediction is correct and btc reaches 250k this year, what will eth reach during this same timeframe?

[huwiler.eth @matthuwiler]

@Evol_D_ART What happened to the grok telegram? Did scammers take it over?

[Shining Science @ShiningScience]

New Alzheimer’s treatment successfully cleared plaques from the brains of mice within just hours, offering a promising new direction for fighting the disease.

In a study led by researchers in China and Spain, scientists injected mice with specially designed nanoparticles that didn’t just deliver drugs—they actually repaired part of the brain’s natural waste-clearing system.

Specifically, they targeted the blood-brain barrier, a protective layer that usually blocks harmful substances from entering the brain but can also trap waste like amyloid-beta plaques, which are linked to Alzheimer’s.

In mice engineered to show signs of Alzheimer’s, just three injections caused amyloid plaques to shrink by nearly 45% within hours. After a full course of treatment, the mice’s memory and learning abilities returned to normal, and the improvements lasted at least six months.

Instead of trying to force drugs through the blood-brain barrier, as past treatments have done, this team treated the barrier itself as the problem—repairing its ability to remove harmful protein buildup from the brain.

The nanoparticles acted like tiny engineers, targeting a specific protein called LRP1, which helps clear waste from the brain. By fixing this “traffic system,” the treatment jump-started the brain’s ability to clean itself.

Scientists describe this process like a chain reaction: once the barrier starts working again, the whole system begins to rebalance, allowing other harmful molecules to be cleared as well. More research is still needed to confirm the treatment’s effectiveness in humans.

[Massimo @Rainmaker1973]

Cancer immunity in a shot.

Scientists at the University of Florida have created a breakthrough mRNA cancer vaccine that erased deadly brain tumors in early human trials without chemo or radiation.

Tested on four glioblastoma patients, the vaccine reprogrammed their immune systems within 48 hours to attack the tumor.

Built from each patient’s own tumor cells and delivered via lipid nanoparticles, it showed success similar to earlier tests in mice and dogs. It is now moving into Phase 1 pediatric trials.

[huwiler.eth @matthuwiler]

@davidasinclair Great study! Have you come across any research including NMNH? Curious how its effects on NAD+ and sirtuins compare.

[huwiler.eth @matthuwiler]

#suiplay finally arrived 😍.