Mayank Gautam

Researcher @Penn • Co-founder NociHeal • Studying Somatosensation • AIIMSonian • My Tweets are My Own • RTs≠Endorsements

[Mayank Gautam @mayankneuro]

Excited to share our paper just published in
@NatureComms on distinct local and global functions of mouse Aβ low-threshold mechanoreceptors in mechanical nociception. Thanks to all the co-authors!
https://t.co/AOnxjva7lw
https://t.co/vKnT2ZFokN

[nature @Nature]

Nature research paper: Deconstruction of a spino-brain–spinal cord circuit that drives chronic pain

https://t.co/Dp1eqeBgns

[Mayank Gautam @mayankneuro]

David Kleinfeld’s Sprague Lecture at @PennMINS deeply thought-provoking. Volitional control of behavior highlights that touch isn’t passive—the brain actively samples the world. Essential thinking for somatosensory neuroscience. #ActiveSensing #Neuroscience #Touch

[Ishmail Abdus-Saboor @IshmailSaboor]

Congratulations to David and Patrick - two pioneering scientists in the touch and pain field whose work has opened up and facilitated the work of so many others.

[Mayank Gautam @mayankneuro]

@IshmailSaboor Congratulations 🎊🎉

[Mayank Gautam @mayankneuro]

@achamess @ASRA_Society Congratulations 🎊🎉

[Ishmail Abdus-Saboor @IshmailSaboor]

Cool new study from @VAbraira lab on tactile hypersensitivity associated with chronic pain. Glad we could collaborate. One cool thing Abraira lab did was use high-speed videography plus the PAWS pain detection system for uncovering pain behaviors.

https://t.co/6lruz3fXsi

[Penn Medicine CSO @PennMedCSO]

ft. @taimeimiaole, @cranphilly, @mayankneuro, @YijingSu2022, You Lu, @UPenn_SongMing, Minghong Ma, Wenqin Luo (@PennMINS), Hanying Yan, @DrMingyaoLi (@UPennDBEI), Stephen Prouty, John Seykora (Dermatology) & @hao_wu_7 (@PennGenetics) https://t.co/AWcNhGuQi1

[ITMAT @UPENN_ITMAT]

Molecular signatures reveal 16 different cell types of human DRG neurons offering #DrugDevelopment opportunities for #ChronicPain #ChronicItch. Explore at https://t.co/3rd5FYUJju #SomatoSensation #TranslationalScience

[Mayank Gautam @mayankneuro]

https://t.co/6KfVOi4VC7
Congratulations again @HuashengY at @Penn and @saadsnagi at @liu_universitet and all collaborators for the fantastic work.

[Nature Neuroscience @NatureNeuro]

Deep RNA-seq of isolated somata from individual human dorsal root ganglia (DRG) neurons identifies 16 neuronal types; molecular-profile-informed microneurography recordings revealed temperature-sensing properties across human sensory afferent types

https://t.co/9F5hfTAUPM

[Neuroscience News @NeuroscienceNew]

16 Nerve Cell Types Identified in Human Touch

In a detailed study, scientists identified 16 unique types of nerve cells involved in the human sense of touch, revealing unexpected complexities in how these cells respond to various stimuli.

Some touch-sensitive cells were found to also react to temperature and pain, challenging traditional beliefs that each nerve cell type has a specific function.

This study mapped gene expression in human sensory cells and compared them to those in mice and macaques, highlighting both similarities and unique human traits.

For instance, humans have more and faster-responding pain-signaling cells, which may be due to our larger body size and the need for quicker responses.

The findings provide new insights into sensory nerve function, showing that nerve cells may serve multiple roles.

This research could lead to better understanding and treatment of sensory processing and pain.

[Alex Chamessian @achamess]

A must read for anyone interested in pain and somatosensation. Congratulations to all the study authors.

[Ishmail Abdus-Saboor @IshmailSaboor]

Cool paper from the lab of my postdoc mentor Wenqin Luo and many other outstanding collaborators of hers including @saadsnagi. Lots to impact here, but one discovery that strikes me is that human C-LTMRs (the gentle touch detectors) also respond to noxious heat. So interesting.

[Saad Nagi @saadsnagi]

1/12 Excited to share our new paper, “Leveraging Deep Single-Soma RNA Sequencing to Explore the Neural Basis of Human Somatosensation,” now out in @NatureNeuro! 🎉 https://t.co/ifqZ2joGFE

[Mayank Gautam @mayankneuro]

@tayler_sheahan @MedicalCollege @MCW_CBNA Congratulations 🎊🎉

[@PennMedBenchmarks @PennMedBench]

Mechanical hyperalgesia is pain from things that should feel like a gentle touch, such as clothes against the skin, but @PennMedicine researchers uncovered clues about what causes this condition to happen https://t.co/4AAhWQBxyD @NatureComms

[Mayank Gautam @mayankneuro]

@IshmailSaboor Very useful for the field. Congratulations!

[Ishmail Abdus-Saboor @IshmailSaboor]

1. Excited to share our improvement of pain testing in rodents. No more back-breaking inconsistent poking of mouse paws. We present the ARM (Automated Reproducible Mechano-stimulator). 1/7

https://t.co/fVUqn19V83

[Mayank Gautam @mayankneuro]

Distinct local and global functions of mouse Aβ low-threshold mechanoreceptors in mechanical nociception. https://t.co/Xb7AMig9xB

[Mayank Gautam @mayankneuro]

@DaveHughes_Gla @IshmailSaboor @NatureComms Thanks David!

[Mayank Gautam @mayankneuro]

Excited to share our paper just published in
@NatureComms on distinct local and global functions of mouse Aβ low-threshold mechanoreceptors in mechanical nociception. Thanks to all the co-authors!
https://t.co/AOnxjva7lw
https://t.co/vKnT2ZFokN