Ralph Mazitschek

ChemicalBiologists, all things small molecule at the corner of science and nature

[Ralph Mazitschek @mazit]

In the recent issue of @nchembio we report the development of #CoraFluors, a #novel class of bright and stable TR-FRET donors optimized for biological #application, including measuring the binding of drug molecules to their targets, directly in #livecells and in real time 🧪(1/n)

[Nature Chemical Biology @nchembio]

The cover of our November issue (https://t.co/d1d755lpIS) features a class of luminescent terbium-based probes called CoraFluors (https://t.co/gPKTURHuuk) used for detecting ligand-bound protein targets by TR-FRET.

[Cell Chemical Biology @CellChemBiol]

Voices: @antolin_aa, Yimon Aye, @LironBarPeled, @Elena_De_Vita, @nata_dudkina, @MichaelCJewett, @hannahjanekc, @mazit, and @SZhangJerry define "What is Chemical Biology." https://t.co/7ueYDNTxUG

[Ralph Mazitschek @mazit]

@KRHornberger @ArvinasInc Congrats

[Ralph Mazitschek @mazit]

@AhmedHBadran @cenmag @scrippsresearch @davidrliu Congrats Ahmed.

[Brian Liau @brian_b_liau]

Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17
#1: https://t.co/8UA8tJ2iti
#2: https://t.co/QOgfdXaxW7

[Ralph Mazitschek @mazit]

@CrisMayorRuiz @NataliaCM___ @Luis_NietoB @adomostegui @ferran_jose99 @BarbMGBarbosa @KarenSfyaki @ines_4412

[Ralph Mazitschek @mazit]

@doc_jlmeier @VRBoombatzMDPhD Sorry my bad. Yes, arsetyl-CoA

[Ralph Mazitschek @mazit]

@doc_jlmeier @VRBoombatzMDPhD Don’t be fooled. Hoechst has as many “r” sounds as “acetyl”

[Ralph Mazitschek @mazit]

@KRHornberger

[Massimo @Rainmaker1973]

What if great scientists had logos

[✏️ Kapil Bhagat & Prateek Lala]

[Ralph Mazitschek @mazit]

Rockstar work championed by @Chemist_Payne and Saki Ichikawa synergistically combines #CoraFluors and #Cyclimids into a powerful platform approach to accelerate degrader development and comprehensive characterization.

[Connor Payne @Chemist_Payne]

Our newest work in collaboration with Saki Ichikawa and @drcmwoo @mazit is now online @CellChemBiol! Here is a free-to-read link:
https://t.co/7b92WWuPGD

[Ralph Mazitschek @mazit]

@RPNowak @IsbBonn @UniklinikBonn @UniBonn @ImmunoSens Congrats Radek. UniBonn is lucky

[Ralph Mazitschek @mazit]

@MichelleFrancl X-Chem probably would not mind

[Ralph Mazitschek @mazit]

Awesome collaboration with #BullockLab and @Chemist_Payne! Combining our complementary expertise, we shed new light on the CUL-3-KEAP1 complex, establish a straightforward assay to measure CUL3 binding to its adaptor proteins, and reveal CDDO’s activity as a “partial antagonist”.

[Centre for Medicines Discovery @CmdOxford]

The Bullock lab @CMDOxford has a new paper on KEAP1-CUL3 structure, TR-FRET and inhibition by CDDO. Great collaboration with Ralph Mazitschek @mazit DOI: https://t.co/yvcZv96X0j

[Ralph Mazitschek @mazit]

@jaybradner Especially Jay-pirca

[Ralph Mazitschek @mazit]

I wonder if we will see certain footage played in reverse to suggest some “visitors” just came to fix things that were broken.

[Ralph Mazitschek @mazit]

@BagPhos From Wikipedia: The official SI unit is the megagram (symbol: Mg), a less common way to express the same mass. - Now, of course, “Mg” is messing with our heads. How many mol are 1 Mg Mg?

[Dan Szymborski @DSzymborski]

My Saturday fun project: using AI, every US president as a Pixar character.

[Connor Payne @Chemist_Payne]

Preprint out!

KEAP1-CUL3 structure, an awesome new assay platform for BTB domain-containing proteins, and elucidating the mode of inhibition of CDDO...what a fantastic collaboration @mazit @MGHCSB @CmdOxford

https://t.co/V63uQ0l2Aq

[Ralph Mazitschek @mazit]

@14Kountz Sorry, this reminded me of Robin Williams in Awakenings. Better luck to you. https://t.co/Nnt5GLiNtb

[Ralph Mazitschek @mazit]

@andpru Not ownership but responsibility