Chimichanga

Stock/futures/options trader, free thinker, infoSEC enthusiast.

[⭕ Brock Pierson @brockpierson]

How come everyone forces introverts to leave their comfort zone for a while but no one forces extroverts to shut the fuck up for a while

[Big Tom Callahan🇺🇸 @CallahanAutoCo]

BRAKING NEWS: I just got off the phone with Mitch McConnell and he agreed to buy 500,000 Brake Pads on behalf of the Great State of Kentucky!

[Chimichanga @mcichocki]

@digijordan Surely there must be a way to resolve this issue safely and effectively?

[Chimichanga @mcichocki]

@SethLederman How do blood results look with Fibro? Are there any metabolic or habitual components to the symptoms?

[Chimichanga @mcichocki]

@SamaHoole Cmon, everyone knows it’s just bad genetics. Why would any of the countless Billions we spend in research go to metabolic root cause analysis, that would be foolish. They are surely very close to curing cancer, a few more Billion is all they need to save us. “THE Science”

[Chimichanga @mcichocki]

@ryanburge What is the sample size and refused is an interesting category, would love more info.

[Chimichanga @mcichocki]

@MetamateDaz Perhaps with inflation making cost of living an exponential, unpredictable equation they are hoping to ensure they can survive their own lifespan.

[Iñigo San Millán @doctorinigo]

For nearly three decades, cancer cachexia has been viewed primarily as an inflammatory disease.

Yet despite enormous scientific effort, therapies targeting inflammatory cytokines have largely failed to stop the devastating muscle wasting seen in patients.

What if inflammation is not where cachexia begins?

In my latest scientific hypothesis, I propose that the process may start much earlier, with cancer’s remarkable demand for glucose.

Through the Warburg effect, tumors behave like a continuous glucose drain, progressively exhausting glycogen reserves throughout the body. As glycogen availability declines, the body increasingly relies on gluconeogenesis to maintain blood glucose, using amino acids from skeletal muscle as substrate.

From this perspective, muscle loss is not simply a consequence of inflammation. It may be the predictable metabolic cost of feeding a glucose-hungry tumor.

This hypothesis connects tumor metabolism, systemic glucose homeostasis, glycogen depletion, gluconeogenesis, and muscle wasting into one integrated metabolic framework.

Whether ultimately proven or not, I hope it stimulates new discussion and perhaps new therapeutic directions, for one of oncology’s most devastating syndromes.

The full article is now available as a preprint and on my Substack 👇

https://t.co/QjyAHGOS9L

https://t.co/lKLMW2oe5B

#Cancer #CancerResearch #Cachexia #WarburgEffect #Metabolism #Mitochondria #Muscle #Oncology #MedicalResearch #Science #Physiology

[Anthony Bradley @drantbradley]

This is one of the best illustrations of what socialism (in any form) does to the poor. It promises a ladder of programs & benefits but can’t lift people out of poverty. No country on earth has made the poor better off under socialist governments.

[james hawkins @james406]

seriously be careful out there everyone

i had 2 Microsoft Copilot licenses in my car, and someone broke in and left 4 more

[Joe Rogan Podcast News @joeroganhq]

They just keep making it shorter and shorter 😂

[Chimichanga @mcichocki]

@washingtonpost

[Locktopus🐙 @LocktopusLines]

On paper Ilia Topuria Wins

Too bad Justin Gaethje can’t read

[Chimichanga @mcichocki]

@timdoke @Alan_Couzens @JohnGoldman Glad I’m not the only one that recalled that, curious on the take on this point. A not great endurance athlete at the time melting through fat caught my attention as well.

[Chimichanga @mcichocki]

@Alan_Couzens @JohnGoldman What about doing shorter cycles to increase fat burning capability/capacity? One thing that stuck out to me was his use of Reta and substantial fat burn at the start of his endurance project. Dosage should matter also, a low dose to quiet hunger seems sensible.

[Chimichanga @mcichocki]

@PenguinWeb3 Also got a pig, but not until arguing about the lack of a base image and saying “use your imagination”.

[PeachProof @PeachProof23]

Mind = BLOWN. I’ve watched Back to the Future a million times and never noticed this insane detail.

Marty McFly literally altered the timeline just by hitting that one pine tree.

The attention to detail in 1985 cinema was unmatched. Did you catch this easter egg the first time around?

[Dudes Posting Their W’s @DudespostingWs]

81-year-old Kenton Brown completing a sub-30 time in the 200m dash is insane....

[Chimichanga @mcichocki]

@pepfessions Any runners/endurance athletes on MOTS-c…what time in relation to your workouts are you taking it? Some stuff I read makes it sound like a pre-workout hit does wonders, just wondering. Thanks.