Marcus Mifflin

U of U chemistry grad student, AGR group- peptide and acyl chemistry enthusiast.

[a. g. roberts chemistry @agr_chemistry]

We collaborated with the @swansongroup_ut, headed by John Nguyen, to better understand principles for the abiotic design of foldable lasso peptides. In silico design of foldable lasso peptides https://t.co/MB066hTP1c (@biophysj open access for now) @utahchemistry @uutah

[a. g. roberts chemistry @agr_chemistry]

our undergraduate researchers have been busy presenting at the capital building, at Utah CUR, and at the undergraduate research symposium! nice work, Ali Nopper, Andre Gohier, and Natalia Danilla! @UtahChemistry @UUtah

[Dave Leigh @ProfDaveLeigh]

Just in time for Halloween💀☠️ skeletal editing of rotaxanes! @MaximeG43877226, Jess & Dan use @LevinChem’s N-deletion reagent to remove template site of dibenzylammonium rotaxanes enabling synthesis of otherwise inaccessible structures.Out now in @J_A_C_S https://t.co/l24lIO9d0f

[J. Am. Chem. Soc. @J_A_C_S]

Thermally Triggered Triazolinedione–Tyrosine Bioconjugation with Improved Chemo- and Site-Selectivity | Journal of the American Chemical Society @ugent #Triazolinedione #Tyrosine #Bioconjugation #Selectivity https://t.co/jWoGYgkFzH

[University of Utah @UUtah]

This year's Commencement student speaker was drawn to the U because of the research opportunities and prestige of @uofu_science. Learn more about Eron Powell: https://t.co/08m7Z5Qdu9

#UtahGrad24 🎓

[a. g. roberts chemistry @agr_chemistry]

way to go, Anh and Marcus @MCMChem ! @UtahChemistry @uutah

[J. Am. Chem. Soc. @J_A_C_S]

The latest issue of JACS is live!

On the cover this week: "Lasso Peptides: Exploring the Folding Landscape of Nature’s Smallest Interlocked Motifs". @agr_chemistry @SwansonGroup_UT

Read the article here ➡️ https://t.co/aACdZzeDRZ

[Swanson Group @SwansonGroup_UT]

Our first JACS cover! 🎉 Productive collaboration with Roberts Group @agr_chemistry unraveling what it takes to get lasso peptides to fold themselves into knots. @UtahChemistry @UUtah @uofu_science

@J_A_C_S Vol. 146 No. 7 - ACS Publications https://t.co/JG3EXk2k6w

[PerrinLab - UBC (posts do not represent UBC) @perrinlab]

Inspired by natural products: optional and efficient installation of two indole-based staples starting with one precursor (suitably protected), both installed on melanotan peptides; all show low-mid nM Kds. https://t.co/An24veNKUl, #peptides, @EurPepSoc, @ampepsoc

[Baran Lab @BaranLabReads]

Published today in @angew_chem : https://t.co/t1WOxILX26

[a. g. roberts chemistry @agr_chemistry]

incredible study to uncover these fascinating cyclization pathways, congratulations!

[a. g. roberts chemistry @agr_chemistry]

Our long-term goal is to understand abiotic lasso peptide folding to inform and enable their chemical synthesis. congratulations to the Swanson/Roberts team! @gcdahora, Myongin Oh, @MCMChem, Lori Digal, Andrew G. Roberts, and Jessica M. J. Swanson

[a. g. roberts chemistry @agr_chemistry]

We collaborated with the Swanson team to understand abiotic lasso peptide folding. Led by @gcdahora, we used new algorithms to better understand how acyclic microcin J25 peptides can adopt pre-lasso folds. https://t.co/psMH7XApof @J_A_C_S @UtahChemistry @UUtah

[Total Synthesis @TotalSynthesis]

A Platform for the #Synthesis of Corynantheine-Type Corynanthe Alkaloids by Yunchan Nam, Anthony T. Tam, Eric R. Miller, and Karl A. Scheidt @ScheidtGroup at @NUChemistry in @J_A_C_S https://t.co/qsFywaMQ47

[a. g. roberts chemistry @agr_chemistry]

Check it out! We synthesized and evaluated the properties of cyclic lasso peptide isomers to discover that the lasso motif is not a required feature to slow cancer cell migration in the sungsanpin / ulleungdin series. #acschembio @UtahChemistry @UUtah https://t.co/qiar2ywqHo

[a. g. roberts chemistry @agr_chemistry]

this awesome Cu-mediated oxidation chemistry from the @PappoDoron group will be useful for the controlled synthesis of biaryl-bridged (poly)cyclic peptides...congratulations to the team! check it out here: https://t.co/yONI9nCfhT

[a. g. roberts chemistry @agr_chemistry]

congratulations to @_EmilyKirkeby_, Zach Schwartz, & @MylesLovasz! Check out our strategy to build polycyclic aromatics involving amine-templated cyclizations and a developed deaminative contraction to seal the deal. @UtahChemistry @UUtah @chemicalscience https://t.co/xV5iId4m21

[a. g. roberts chemistry @agr_chemistry]

A promiscuous #rSAM enzyme enables diverse peptide cross-linking https://t.co/YIpsGKNgKd Working together with @taikade @MCMChem Paul Oblad, and @Vahooster (Bandarian) we show that PapB has a high tolerance for variations in the peptide substrate. @UtahChemistry @UUtah

[a. g. roberts chemistry @agr_chemistry]

the Stevens rearrangement remains useful for the synthesis of polycyclic natural products, check out the review @MylesLovasz, @ValitonChelsea, and Zach Schwartz wrote in SYNTHESIS @thiemechemistry: https://t.co/ZNELmGeh4f @UtahChemistry @UUtah

[a. g. roberts chemistry @agr_chemistry]

looking forward to this: