Mukta Deobagkar

Immunologist, Book Lover, Wanderer

[Mukta Deobagkar @MDeobagkar]

Check out our new @SciImmunology paper about the role of DOCK8 in the survival and differentiation of B cells activated by low amounts of antigen: https://t.co/1GleROZMZf
A big shoutout to @CornallLab & @BetterKidneys Thank you @MRC_TIDU @HumanGeneticsOx @NDMOxford @CAMS_COI_Ox

[Rahul Satija @satijalab]

Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at https://t.co/JqaO6urVPF

[Immunity @ImmunityCP]

Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs https://t.co/d2pzIqiiRY

[Garvan Institute of Medical Research @GarvanInstitute]

New Garvan research reveals how hepatitis C triggers autoimmunity through B cell mutations – not molecular mimicry as previously thought.

Published in @ImmunityCP, this could transform treatment approaches for a range of autoimmune diseases.

https://t.co/EQvJpVWgR0

[Waggoner Lab @LabWaggoner]

The molecular reach of antibodies crucially underpins their viral neutralization capacity
https://t.co/qkQLHRXMGy
@NatureComms @Dushek @annagesine

[Waggoner Lab @LabWaggoner]

Metagenomic immunoglobulin sequencing reveals IgA coating of microbial strains in the healthy human gut
@NatureMicrobiol @GutBugs2 @MattagenOlmics
https://t.co/ZnikG8jMqB

[Journal of Experimental Medicine @JExpMed]

Cao, Burrows, @nkg2d1 @theonlylabever et al. show that Tritrichomonas musculis-driven IgA modifies the commensal bacterial microbiota and improves the generation & dissemination of IgA-secreting plasma cells reactive against orally ingested food antigens. https://t.co/nk1MhHT3x1

[Science Immunology @SciImmunology]

New research from @YaleIBIO reveals that natural antibodies secreted by a subset of #Bcells prevent reactivation of endogenous #retroviruses in mice.
@VirusesImmunity @YYexin

Read more in Science #Immunology: https://t.co/GlSf9GlYh7

[Waggoner Lab @LabWaggoner]

Integrin-αV restricts tissue-resident airway B cell responses by reducing persistence of germinal center reactions locally in the lungs, limiting lung-resident IgA+ memory B cells that are cross-reactive to antigenic variants
https://t.co/gBa4I9nz2J

[Ejv @ejvillablanca]

A must read!

The renaissance of oral tolerance: merging tradition and new insights | Nature Reviews Immunology https://t.co/qf5iwVsJMC

[Saligrama lab_WUSTL @SaligramaLab]

If one believes in #TCR #crossreactivity, read this #1000times or even more. T Cell Receptor Cross-Reactivity between Similar Foreign and Self Pept... https://t.co/McPikxzAZ0

[Science Immunology @SciImmunology]

A two-shot #vaccine regimen, delivered a week apart in increasing doses, prolongs antigen capture and boosts T cell priming and #Bcell responses in mice.

Read more in Science #Immunology: https://t.co/3YRq6yoZWq

[Casanova Lab @casanova_lab]

Monumental paper by Helen C. Su and collaborators, with profound biochemical, immunological, and clinical implications:
Germline mutations in a G protein identify signaling cross-talk in T cells | Science https://t.co/9tUSBBSIuK

[Waggoner Lab @LabWaggoner]

Vaccine delivery in two doses, synchronized to germinal center dynamics and T cell priming, enhances humoral immunity @SciImmunology #Chakraborty #Irvine @sachinbhag
https://t.co/UFCFyN1Z7G

[Waggoner Lab @LabWaggoner]

Trained immunity-based vaccines for infections and allergic diseases @jacionline @Palomares_Lab
https://t.co/noiJMi3nq1

[Sachin Bhagchandani (he/him) @sachinbhag]

I'm excited to share the final piece of my doctoral research published today wherein we demonstrate that a two-dose priming vaccine regimen amplifies humoral responses by synchronizing delivery with germinal center dynamics https://t.co/eJspUYaPnA

[Ali Dvorscek @Ali_Dvorscek]

Incredibly excited that our work is now out in @ImmunityCP!

Here we reveal the mechanistic principles of antibody (Ab)-mediated B cell response regulation, ultimately highlighting the utility of Abs to enhance both protein- and mRNA-based vaccines

https://t.co/WFo8eq7w7w

[Waggoner Lab @LabWaggoner]

Mechanistic framework of how antibodies can optimize protective immunity, regulating B cell response participation and duration in a way that can be harnessed for vaccine design @ImmunityCP @isaak_quast
https://t.co/DA8VPZdQ5q

[Waggoner Lab @LabWaggoner]

Changes in transcript isoforms can alter the function of interferon stimulated genes in human B cells @CellGenomics
https://t.co/RYzOEk2X0W

[Nature Rev Immunol @NatRevImmunol]

Towards a unifying model for B-cell receptor triggering https://t.co/y5bNBaWP3r

[Adán Pinto Fernández @adanpinto]

Preprint alert 🚨 . Another great collaboration with Aysegul Sapmaz and Paul Geurink in Leiden. This time we identified and characterised USP24 as a deISGylating enzyme with roles in IFN-I production and potential use as an antiviral target. #ubiquitomics