Matthis Desoteux

#PhDstudent in #Cellbiology @Inserm, @UniversiteRennes1 #LiverCancer #EMT #CRISPRscreen

[Matthis Desoteux @mdesoteux_]

@GuyRouxxx @GreenGan4 @crapoulet77 @Huntersavant Effectivement, quelle hérésie... Vous imaginez vous, faire 10 ans d'études pour une spécialité choisie par dépit en raison de l'incompétence des dirigeants ?

[Journal of Hepatology @JHepatology]

🆕Editorial | One stone, two birds: circACTN4, a nexus for a coordinated activation of Hippo and Wnt/β-catenin pathways in cholangiocarcinoma
➡️https://t.co/a0kJnWpZVF

By @C_LOUIS1 & @CoulouarnC

Refers to👉https://t.co/CfzGKMfbGF

#HCC #circRNA #cholangiocarcinoma

[Dr. Luis E. Gomez-Quiroz @luisgomezquiroz]

The Consumption of Cholesterol-Enriched Diets Conditions the Development of a Subtype of HCC with High Aggressiveness and Poor Prognosis https://t.co/GkOXmLnB2Y via @MDPIOpenAccess @jumarquardt @CoulouarnC @arturo_vedder @Antimio @CBS_UAMIzt

[David Gilot @david_GILOT]

We performed in vivo gain‐of‐function CRISPR screens and identified SMAD3, BIRC3, .. as key actors of BRAFi resistance.
AhR‐SMAD3 axis promoted BRAFi‐resistance and cell plasticity. Inhibition of SMAD3 alone or in combination with BRAFi impaired survival of BRAFi‐resistant cells

[jobRxiv @jobRxiv]

Post-Doctoral Fellowship – lncRNA, CRISPR & Cancer

INSERM U1242, Université de Rennes 1, France

https://t.co/XBppGWPDUO

#ScienceJobs

[Andrew Payne @Andrew_C_Payne]

New paper released today at Science, introducing "in situ genome sequencing", a method we invented to sequence DNA inside intact cells using a microscope! This lets us look at the 3D spatial structure of the genome (🔬XYZ), not just its sequence (🧬ACTG). (1/4)

[Ievgenia Pastushenko @Dr_Pastushenko]

FAT1 mutations promote hybrid EMT state, metastasis and resistance to therapy. Our new paper published in @nature 🥳🥳🥳 👇👇 @CedricBlanpain @F_Helmbacher @ULB @ERC @EmbEspBelgica @FcontreleCancer @Temptia @OzTEMTIA @WELBIO @MetastasisRS @ULBRecherche https://t.co/2KjNL1AeU0

[Jean-Charles Nault @NaultJc]

Our new work on Telomere length is key to hepatocellular carcinoma diversity and telomerase addiction is an actionable therapeutic target in ⁦@JHepatology⁩ ⁦by Massih Ningarhari ⁦⁦@Zucmanrossi⁩ ⁦@SRebouissou⁩ ⁦@CRCordeliers⁩ https://t.co/jkXuONV1h5

[David Gilot @david_GILOT]

We are hiring. We are looking for a postdoctoral fellow to study the role of lncRNAs in therapy-resistance. Please RT.
CRISPR screen and long-read RNA sequencing.
Candidates should have experience in CRISPR-based gene editing and would be “RNA-friendly”. WELCOME.

[Ed Yong is not here @edyong209]

🚨I wrote about the rampant use of "strength" and "fighting" metaphors following Trump's COVID-19 diagnosis, the history of such language when talking about disease, and why it misleads, distracts, and makes things worse. 1/

https://t.co/3VULnpDfQQ

[Science Magazine @ScienceMagazine]

"You are not alone."

In a 2017 study, over 50% of doctoral students reported experiencing at least two symptoms of poor mental health in recent weeks, highlighting the mental health challenges that many graduate students face. #WorldMentalHealthDay https://t.co/a79MlXMJJ3

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

[Semaine du Cerveau_Rennes @SemCerveau35]

Stress cellulaire, glioblastome et pistes thérapeutiques: les recherches du biologiste @InsermGrdOuest Tony Avril
@Eugene_Marquis @CSignaling

[Espace des sciences | Rennes @Espace_sciences]

🍌 De l'ADN de la banane au test de dépistage Covid-19... les étudiants de @LucaRennes font la démonstration au Village des sciences @LesChampsLibres
https://t.co/NxHFMkD72B
#FDS2020 @FeteScience @metropolerennes @ille_et_vilaine

[LUCA-Association doctorants ED-SVS de Rennes @LucaRennes]

L'association LUCA reprend de l'activité ! Cela commence par la Fête de la science (@FeteScience) le 3-4 Octobre aux Champs Libres de Rennes. Nous continuerons avec la reprise des "Doct'Oral" dès le 15 Octobre ! Les infos arrivent prochainement.

[Coulouarn Cédric @CoulouarnC]

Happy to share our recent review on #lncRNA in #CCA
Long non-coding RNAs in cholangiocarcinoma https://t.co/DiLjlpblqM

[Matthis Desoteux @mdesoteux_]

Really nice poster ! Congrats @C_LOUIS1👏👏👏
@EASLnews @CharityAMMF #ILC2020 #Cholangiocarcinoma

[Coulouarn Cédric @CoulouarnC]

Congrats to @C_LOUIS1 for his great presentation on circular RNA in #CCA at #ILC2020. Pround of you on behalf of the team!

[Axel Kahn @axelkahn]

HCQ est actif en cultures de cellules sur la production de plusieurs virus. Dont CoV-2. Jamais chez les malades. Voici pourquoi : En culture, CQ et HCQ inhibent un mécanisme de réplication viral différent de celui in vivo. https://t.co/KvnaOgDb2h

[Nature Portfolio @NaturePortfolio]

Hydroxychloroquine shows no substantial antiviral activity in cynomolgus macaques infected with SARS-CoV-2 regardless of the timing of treatment initiation, either before infection, soon after infection or late after infection, according to a Nature paper. https://t.co/jwVs7Aj9HI

[David Gilot @david_GILOT]

Happy to share our first preprint. Wonderful collaboration with @lab_marine on #melanoma and #BRAF inhibitor. CRISPR screens highlight #AhR-SMAD3 pathway =>EMT. Fantastic work done by Gautron et al.