@SaranDavies Hi Saran. This is Christian the lead author on the paper. We have had good success matching MIC measurements of broth micro dilution assays to GVA-based MIC by adding the drug directly in the pipette tip. As a bonus, you can measure the degree of heteroresistance in a sample.
Pleased to share our preprint on bacterial zombies! These zombie cells are non-viable but they reshape the antibiotic tolerance of other species via paracrine secretions. Great working with @kralj_lab alumni @BruniGN and Ben. @BioFrontiers@CUBoulder
https://t.co/tMKTayb4qZ
.@meyerct6@quarantalab@ceelox4@AlexLubbock present #MuSyC, a consensus synergy metric for characterizing combinatorial drug interactions. #MuSyC overcomes several caveats associated with popular synergy metrics.
https://t.co/pfx3aL1MIV
Happy to share our paper online today at Cytometry A describing DebarcodeR - an algorithm for demultiplexing fluorescence cell barcoded (FCB) flow cytometry data. (1/12) @jonathanirish @BrianOBachmann
https://t.co/HpIk1Dw81D
New work from @BioFrontiers on machine learning applied to detecting antibiotic sensitivity. Thanks to Joel Kralj, Megan Jewel, and @eugenejomiller! Machine Learning Establishes Single-Cell Calcium Dynamics as an Early Indicator of Antibiotic Response https://t.co/xmAa6n3pSR
A Bayesian framework for intelligently deploying universal COVID testing: https://t.co/WYY2UJV81r
Related to the recent, fantastic article by @TomChivers in @guardian https://t.co/U08jeMKmhp
This week in the field of mathematical oncology: issue 105.
<glioblastoma models, drug synergistic effects, the cancer microbiome, organoid dynamics>
https://t.co/vGrl6JMmv9
Really nice overview by the @quarantalab on assumptions on biology and data made by different #DrugSynergy models. This is critical when choosing the right synergy model for your data!
https://t.co/rdKY18PVGh
@houndcl@VICB_Vanderbilt @cispt2 @CellPressNews@quarantalab@ceelox4 Thanks @houndcl for your kind words. I am the beneficiary of a great consortium of scientists, including yourself, who go to work every day trying their best to make the world a better place. "If I have seen further, it is by standing on the shoulders of Giants." -Newton
Carlos Lopez & Vito Quaranta tackle issues impacting all aspects of combination therapy discovery and deployment in this CellPress review article titled "Charting the Fragmented Landscape of Drug Synergy" https://t.co/ToJ5jUgBfG @CellPressNews@quarantalab@ceelox4@meyerct6