Abhijit (Jeet) Naik

Physician-Scientist at large @UMich, Informatician, always in flux regardless of pore size. Tweets are my own views and not medical opinion.

[Journal of Clinical Investigation @jclinicalinvest]

Metabolic #BariatricSurgery in youth with #diabetes and obesity is associated with improved kidney outcomes. However, the mechanisms underlying kidney protection is unclear.

https://t.co/qmmUULuOR7
Here, Abhijit S Naik @minimalchange & team @UMichMedSchool explore structural and transcriptomic changes before and after vertical sleeve gastrectomy in kidneys of obese youth with diabetes, revealing targets for non-surgical interventions against #KidneyDisease.

[Abhijit (Jeet) Naik @minimalchange]

JCI Insight - The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure https://t.co/6vwktJ8nvx

[Abhijit (Jeet) Naik @minimalchange]

We propose GH-IGF1 mediated signaling as a potential risk factor for long term kidney allograft survival.

https://t.co/nN7m7RlL9b

[Abhijit (Jeet) Naik @minimalchange]

Glomerular Elasticity and Gene Expression Patterns Define Two Phases of Alport Nephropathy https://t.co/YSkxxrWrqh

[AJKD @AJKDonline]

In the Literature commentary by @minimalchange and Frank C. Brosius:

Cannabinoid Signaling in the Diabetic Proximal Tubule: Of Mice and Men

https://t.co/1CqYF80ziZ (FREE)

[Abhijit (Jeet) Naik @minimalchange]

https://t.co/MMVDhdepTM
Identification of glomerular cell type stress after kidney transplant at a single cell resolution. We observed significant reduction in nephrin and key integrin (ITGA3) both at an mRNA and protein level. Thanks KPMP, HCA, NIDDK

@MiKTMC @UMichKidney

[Abhijit (Jeet) Naik @minimalchange]

@SamiAlasfar @hopkinsneph That’s signature Dan.

[Abhijit (Jeet) Naik @minimalchange]

@AlanB_16 @GovWhitmer If you don’t understand rhe concept of how mRNA Technology is used in making a vaccine-then 1. Repeat highschool 2. Study, read the science. Or just shut up.

[Abhijit (Jeet) Naik @minimalchange]

@AndrewFMalone @WUTransplant thanks for the awesome resource Andrew.

[Abhijit (Jeet) Naik @minimalchange]

https://t.co/ZlbehyH5pv

The timing of ACE inhibition in relation to uni-nephrectomy has significant impact on hypertrophic stress associated single kidney outcomes. Ramifications for kidney transplantation and live donors?
@UMichKidney @UMIntMed

[Abhijit (Jeet) Naik @minimalchange]

Urine marker analysis identifies evidence for persistent glomerular podocyte injury across allograft lifespan https://t.co/jRwfDgTLou

Our heuristic approach in testing the idea that podocyte injury and detachment continue across lifespan of allograft. @UMichKidney

[Abhijit (Jeet) Naik @minimalchange]

Urine marker analysis identifies evidence for persistent glomerular podocyte injury across allograft lifespan https://t.co/jRwfDgTLou

Our heuristic approach in testing the idea that podocyte injury and detachment continue across lifespan of allograft. @UMichKidney

[Abhijit (Jeet) Naik @minimalchange]

SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease https://t.co/ogwSMSKybT . @MiKTMC @UMichKidney @umichmedicine @Berthiercc @OlgaTroyanskaya .

[Kidney International @Kidney_Int]

#GraphicalAbstract
https://t.co/icYtAfW5kU
@minimalchange @UMichKidney

[Nada Alachkar @NadaAlachkar]

I think it is a very important cause of late kidney allograft failure! #ATC2020Virtual

[Abhijit (Jeet) Naik @minimalchange]

New from a fantastic group @MiKTMC /Princeton as preprint that leverages the power of scRNAseq to demonstrate how cells in pathologic environments (e.g. diabetes) have their cellular machinery primed for viral (SARS-CoV-2) entry. https://t.co/u4ivBcgeeU

[Abhijit (Jeet) Naik @minimalchange]

@jaykoyner @rheault_m Non randomized, non controlled data= Believe what you want to believe.

[Abhijit (Jeet) Naik @minimalchange]

@jaykoyner @rheault_m I have seen unbelievable crap published in the last month and half.

[Abhijit (Jeet) Naik @minimalchange]

See our paper in KI that uses nephron segment specific urine mRNAs to explore how systemic blood pressure might initiate and drive subclinical glomerular injury and affects glomerulus >> tubular compartments. https://t.co/lT34ebyQ8z
@UMichKidney @UMIntMed @MiKTMC @Kidney_Int

[Michigan Kidney Translational Med. Center (MiKTMC) @MiKTMC]

1/7 We just published a new single-cell transcriptomics study in @JCI_Insight using @KPMP, #NEPTUNE, and #ERCB data. https://t.co/G4rnp7rMwL Check out the single-cell data in our new tool: https://t.co/Td235Zo6Lh