MitophagyNews

Summarising the latest news about #mitophagy. Curated by @mkfrison92 @Aitor_Mtz.

[Martin Picard @MitoPsychoBio]

To understand aging, we need to reconcile the sub-cellular molecular hallmarks of aging with whole-body aging phenotypes

[Ganley Lab @LabGanley]

New paper out! #AMPK regulates #ULK1 to balance #mitophagy of functional vs dysfunctional mitochondria in @MolecularCell. Great work from authors, especially Marianna Longo @AnikethBishnu and collaborators @Kei_Sakamoto @CarolMacKintos1. See it here: https://t.co/BVDu2ilrQ9

[Madam Mitochondria @Madam_Mito]

Targeting organ-specific mitochondrial dysfunction to improve biological aging;

https://t.co/zRKn3MsHJE

[Luis Carlos Tábara Rodríguez @Tabara_LC]

Please have a look at our recent review on mito-dynamics!

[Anna Vainshtein, PhD @VainshteinAnna]

Hey #myotwitter enjoy this week’s selection of papers on skeletal muscle, aging, and exercise.
👇
https://t.co/TDFtpbAA9b

Featuring work from
@BowermanNMD
@AranyLab
@VIKorolchuk

[Mitochondrial Medicine @Mito_Therapy]

Good Sunday Mitofriends, don't miss this selection of papers related to Mitochondrial Medicine presorted by
@Bims_BiomedNews

https://t.co/xE6OhCmkZx
https://t.co/LcAEsI7gwk

CAPTION: Molecular mechanisms of mitochondrial dynamics

[Journal of Cell Biology @JCellBiol]

Takami Sho, Li Yu et al. @Tsinghua_Uni unveil migratory autolysosome disposal, a response to #lysosome damage where cells expel LAMP1-LC3 positive structures via autolysosome exocytosis, requiring #autophagy machinery, SNARE proteins, and cell #migration. https://t.co/4qRC6TaoRk

[Hanna Salmonowicz @HSalmonowicz]

I am honoured to coauthor one of my favourite papers of all times when it comes to #mitochondria #ageing and #senescence! https://t.co/N4O1DPxVtb

So things are not always as we dogmatically assume. Mitochondrial and "-phagy" dysfunctions are reported to occur with ageing...

[Cell Biology J-Club @cell_club]

A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy https://t.co/jnFH4qYtVV

[Roberta Filograna @RobertaFilogra2]

Our study is finally out! https://t.co/RYUgW9J8ow
We here show that PARKIN is dispensable for OXPHOS function in adult mouse tissues and in skeletal muscle from a PD-patient.
Thanks to @mitopinionated , @LabMotori, @perlmannlab and Per Svenningsson for the great collaboration!

[Juan Melero-Martin @MeleroMartinLab]

Our latest @Nature paper is out! We show that transplanting mitochondria into endothelial cells boosts their ability to form blood vessels in ischemic tissues, with mitophagy as the key mechanism. A potential game-changer for vascular cell therapies. https://t.co/ViscFIc9sv

[Mitochondrial Medicine @Mito_Therapy]

Good Sunday Mito-friends, don't miss this new selection of papers related to Mitochondrial Medicine presorted by
@Bims_BiomedNews

https://t.co/aqxG3NwYke

CAPTION: Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons

[Jean-Francois Trempe @jftrempe]

We just published our investigation on PINK1 inhibitors; PRT062607, a SYK inhibitor, also inhibits PINK1 (IC50 1 uM). The inhibitor is not selective for PINK1, but paves the way to the development of PINK1 selective chemical probes: https://t.co/tgrSOoiMlz

[Jean-Francois Trempe @jftrempe]

Our article on PINK1 forming a complex with TOM and TIM23 is out today. Congrats Mohamed and Andrew! Great collaboration with the Fon lab. https://t.co/hbGG2zd2D3

[Aitor Martinez @Aitor_Mtz]

New mitophagy BiomedNews issue to keep you updated!

Highlights:

Highthroughput proteomic assay for Parkin activators

Inner mitochondrial membrane exposure triggers apoptotic mitophagy

https://t.co/i519LF09bw

[Dr Tahnee Saunders @tahneesaunders]

And after what seems like forever, my first first-author publication is finally online for the world to read. https://t.co/GgBsLXkUM1

[Miratul Muqit @miratul_neuro]

Really enjoyable collaboration with @v_decesare and team on new high throughput assay for #Parkin activators. #Parkinsons #drugdiscovery
Click here for paper: https://t.co/CyhqsM4P5t

[FrezzaLab @FrezzaLab]

The HRI branch of the integrated stress response selectively triggers mitophagy: Molecular Cell https://t.co/JhgaZf6pgM

[Cell Biology J-Club @cell_club]

SLC-25A46 Regulates Mitochondrial Fusion through FZO-1/Mitofusin and is Essential for Maintaining Neuronal Morphology https://t.co/TzcikF2Tcx

[Cell Biology J-Club @cell_club]

Optineurin provides a mitophagy contact site for TBK1 activation | The EMBO Journal https://t.co/vHLvRawvfm