Mithun Mitra

Project Scientist @UCLA | Cellular quiescence, cancer heterogeneity, gene regulation, TFs, epigenetics, aging | Previously postdoctoral fellow @NIH.

[Mithun Mitra @mitramith]

Thanks @NatureCellBio for giving us this opportunity. Our review on Transcription factor networks in cellular quiescence can be read here: https://t.co/r8rpZLJgdI #transcriptionfactor #quiescence

[Nature Cell Biology @NatureCellBio]

👋🏿Happy new year and our first 2025 issue's out!
Cover: #chromosomal instability in #cancer

👉Review on #TranscriptionFactors and #cell quiescence
🔬#heterochromatin #embryo #DNArepair #pluripotency #proteostasis #obesity #CellCycle #CellDeath & more!
https://t.co/e33NMHln7Q

[Dan Landau @landau_lab]

Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

[nature @Nature]

New-found immune cells called ‘ruptoblasts’ explode when triggered, ejecting toxic chemicals capable of delivering death to surrounding cells in just minutes. The cells’ discoverers say that this process, which they call ruptosis, seems to be a new form of cell death.

https://t.co/6JtcC1HjY0

[Tjian + Darzacq Group @TjianDarzacq]

Out now in Science! Our new study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵
https://t.co/w5mYmh4I1G

[Guolan Lu @GuolanLu]

1/8 ✨Thrilled to share that our paper is now online
@NatureBiotech
“Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors”
https://t.co/Gm5vVtduHT
(open access): https://t.co/UuxG8JJC2M

[Junyue @junyue_cao]

New preprint alert! 🚀 Across 60 human cancer cell lines spanning 20 cancer types, single-cell RNA+ATAC reveals pan-cancer cell-state heterogeneity, core gene-regulatory networks, and an EMT axis conserved across tissue origins.

Huge congrats to first author @xu_zxu, who recently defended his PhD, and Aileen Ugurbil from our lab @RockefellerUniv! https://t.co/4fNQJlJY3m

[Mithun Mitra @mitramith]

G0 or no-G0: phosphatase control of #quiescence and cell cycle entry https://t.co/s1qX8ltCTe

[Cancer Cell @Cancer_Cell]

Online Now: Engineered enhancers: Using tumor switches for precision therapy https://t.co/LYLJiIfcTY

[Nature Reviews Drug Discovery @NatRevDrugDisc]

Autophagy modulation in cancer
https://t.co/Cr3Ifpl2jD
https://t.co/XF4iioO5bl
This new Review discusses the promise and limitations of targeting autophagy to limit malignant transformation, exacerbate cancer cell death driven by conventional drugs and restore immunosurveillance

[Cell Genomics @CellGenomics]

Essential lncRNAs in the human transcriptome https://t.co/jtuWNcy3DS

[Nature Reviews Cancer @NatureRevCancer]

NEW content online! Regulation of immune checkpoint molecules in cancer immune evasion and therapy https://t.co/Akm5jtVmZd

[nature @Nature]

Nature research paper: Ecotypes of triple-negative breast cancer in response to chemotherapy
https://t.co/a7wEoOA6N2

[Epigenome Technologies Inc. @EpigenomeTech]

Epigenetics Update - An EGFR co-amplified lncRNA HELDR promotes glioblastoma malignancy through KAT7-driven gene programs https://t.co/uCwKnvAbSR

Xiaozhou Yu & Bo Hu/Shi-Yuan Cheng @NUFeinbergMed in Nat Cell Biol

#Epigenetics #KAT7A #lncRNA #GBM
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https://t.co/WmSYDGWPJD

[Rahul Satija @satijalab]

Interested in single cell and spatial genomics? Check out the agenda for our 10th Single Cell Genomics Day on Friday 6/12.

Speakers: Aviv Regev @anshulkundaje @junyue_cao @xinjin + many more! All talks are free and live-streamed at https://t.co/KJpeGwWLIr

[Mithun Mitra @mitramith]

Whole-genome doubling drives immune evasion by silencing antigen presentation: @Cancer_Cell https://t.co/LJOEGfPHF3 #epigeneticsilencing

[nature @Nature]

Nature research paper: RNA-triggered cell killing with CRISPR–Cas12a2

https://t.co/gHPUK2JsFa

[Aaron Newman Lab @AaronNewmanLab]

1/ Thrilled to share our new paper, out today in @Nature: "Non-invasive profiling of the tumour microenvironment with spatial ecotypes".

Paper (open access): https://t.co/EujZFqU7wi

[Nature Chemical Biology @nchembio]

A new Perspective discusses recent developments in RNA modifications on chromatin-associated RNAs, how they modulate chromatin states, and future direction for studying RNA regulatory elements to control gene expression

https://t.co/a2tMAH02ra

[ShorterLab @ShorterLab]

Programmable artificial RNA condensates in mammalian cells: https://t.co/Gvx81656mS

[Nature Cancer @NatureCancer]

📢Today we launch our Series on Tumor Heterogeneity and Plasticity featuring commissioned Reviews and a selection of articles published in Nature Cancer!
Read about EMT, CAF plasticity, immune cell plasticity, cellular neighborhoods and more here:
🔗https://t.co/XudgPd5Vax

[Arc Institute @arcinstitute]

Today in @Nature, the @genophoria & Vijay Ramani labs reveal that our picture of how nucleosomes regulate DNA accessibility has been too simple. They find that over 85% of nucleosomes in mammalian cells are structurally distorted, with DNA partially accessible even while wrapped.