Michael Gutbrod

Biotech investing, former postdoc at CSAIL/MIT - disease dissection with single cell genomics and stem cell models, CSHL PhD

[Luke Timmerman @ldtimmerman]

Timmerman Traverse for Damon Runyon Cancer Research Foundation has hit its $1M goal. One month to go before Kilimanjaro. https://t.co/xb01xFyZoG

[Michael Gutbrod @mjgutbrod]

@paul_masset @mcgillu @McGillPsych Congrats Paul!

[Shahram Seyedin-Noor @ShahramSN]

If you're a #LifeSciences VC or #founder, read this first before #JPMorgan2023.

This 2011 paper by Santé has fresh relevance as the biotech bubble has burst, and old norms return.

Big funds (>$300M) will underperform B I G.

Key take aways. 👇 (1/9) 🧵

https://t.co/fgDnyLvRUV

[Justus @JustusKebschull]

Come work with us! The Kebschull lab is looking for a postdoc to work on barcoding and comparative connectomics @JHUBME !

https://t.co/TbSJorBxOG

[Luke Timmerman @ldtimmerman]

They're hiking 20 miles, climbing 8,200 ft., and raising $500,000 to fight poverty. The Timmerman Traverse for @LS_Cares: @vintweeta @SamTruex @ksbosley @ArtKrieg Doug Fambrough @DicernaPharma Reid Huber @ThirdRockV Katherine Anderson @SVB_Financial GIVE: https://t.co/9cHhBJm2mb

[Michael Gutbrod @mjgutbrod]

This is simply a stunning achievement!

[Sek Kathiresan MD @skathire]

Does chronic disease need to equal chronic care? No

👇in @Nature from @VerveTx

One-time base editing Rx (in vivo liver),
durable⬇️LDL-C

In monkeys:

*⬇️90% PCSK9,⬇️60% LDL-C, now out to 10 mos

* VERVE-101: efficacy at LNP doses as low as 0.5 mg/kg

https://t.co/rimsHKld8c

[Ben Harris @b_harris_12]

1/ What does the resolution gained by scRNAseq, over bulk, tell us about co-expression networks in cell types? Using 7 datasets from the MOp and over 50 bulk RNAseq experiments we show how remarkably similar co-expression networks are between bulk and scRNAseq data.

[Nature Neuroscience @NatureNeuro]

Development of #BARseq2, a technique that simultaneously maps projections and detects multiplexed gene expression by in situ sequencing; new from @TonyZador and colleagues at @CSHL

https://t.co/FFmdvNd7IV

[Frank Willett @WillettNeuro]

Our new study is out today in Nature! We demonstrate a brain-computer interface that can turn thoughts about handwriting into text, enabling a person with paralysis to type 18 words per minute – doubling the prior record. 1/3
https://t.co/l3PaBnm0Uv

[Justus @JustusKebschull]

Are you interested in
BRAIN EVOLUTION, CONNECTOMICS, and SPATIAL TRANSCRIPTOMICS?

Then come join us @JHUBME @JohnsHopkins. The KEBSCHULL LAB is looking for a Postdoc!

Please RT and spread the word. #newPI #postdocjobs @jhneurostudents

[Cold Spring Harbor Laboratory @CSHL]

CSHL plant geneticist Rob Martienssen looks towards #duckweed and the scum-like forests it makes to put carbon back into the earth and drive down global warming. https://t.co/CecykxeW5U

[Johns Hopkins BME @JHUBME]

👋 Meet @JustusKebschull. He joined #HopkinsBME as an assistant professor in January. Learn about his research on organizational principles of vertebrate brains, a “eureka moment” he experienced, his goals for the future, and more. Read: https://t.co/UXst3ITtz3

[Manolis Kellis @manoliskellis]

Our #EpiMap paper is now @Nature: systematic dissection of #DiseaseCircuitry, including predicted driver variants, enhancers, regulators, target genes, and relevant tissues/cell types across 30,000 genetic loci, 540 traits, 833 tissues https://t.co/75rulhGnWr #Epigenomics #GWAS

[David R. Liu @davidrliu]

Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 https://t.co/O7dkEYpndg

[Michael Gutbrod @mjgutbrod]

Really cool work, can't wait to see what comes next! Join the new Kebschull Lab ! - https://t.co/GncQ09qEQX

[Justus @JustusKebschull]

Super happy to announce that this work analyzing how brain regions evolved is now out in Science! During review, we added STARmap data from chickens, lots more analysis, and doubled the size of our human snRNAseq dataset. Check it out below!
https://t.co/J5s8xBIsVv

[Whitehead Institute @WhiteheadInst]

Tobiloba Oni @CancerHacker, a cell biologist whose graduate research @CSHL helped open new paths for understanding, detecting, and potentially treating pancreatic cancer, has been appointed as a Whitehead Fellow. He will open his lab in Feb. 2021: https://t.co/GevKyd1Z8j

[Shahin Mohammadi @ShahinMohammadi]

After a long journey, it's finally out to share with the community!

[Jiekun (Jackie) @yangjiekun]

Thanks, Manolis! You can tune in to my live presentation and Q&A at 10:30 ET Oct. 30 (Session 40) for “Single-cell dissection of obesity-exercise interaction across four tissues”. Excited for the virtual experience of #ASHG20!

[Manolis Kellis @manoliskellis]

Don't miss our four #ASHG20 talks today/tomorrow on #SingleCell dissection of #Alzheimers #Obesity #Exercise #Schizophrenia using #scRNA #scATAC #GWAS #eQTLs #Mosaicism Big congrats to #MariaKousi #AustinWang #XushenXiong #JackieYang and our collaborators!