wu Yan 吴 衍

[wu Yan 吴 衍 @mmmmmsehbt]

@TonyDotX @Bos360face @cz_binance 你除了干这个还能干嘛

[wu Yan 吴 衍 @mmmmmsehbt]

@TonyDotX @Bos360face @cz_binance 🙄🙄

[wu Yan 吴 衍 @mmmmmsehbt]

@AgentM_Tech @BenTodar @cz_binance 帽子罪，莫须有

[wu Yan 吴 衍 @mmmmmsehbt]

@AgentM_Tech @BenTodar @cz_binance 差不多得了，真是闹麻了，天天间谍

[wu Yan 吴 衍 @mmmmmsehbt]

@liubasova_ 可能是你读的是俄语吧

[Bryan Johnson @bryan_johnson]

Plasma exchange can remove unnatural pollutants which our body including liver, kidney and immune system is not capable to remove including microplastics, and other such POPs (persistant organic polluatnts).

Age plasma proteins including albumin, lipoproteins, and cytokines also decline in quality due to various types of damage including the reaction with sugars (glycosylation).

While the body is capable of making new proteins, the old damaged proteins lurking in the plasma inhibit efficient replacement, and removing them accelerates the replacement with newly made “youthful proteins”.

Our detoxification systems take care of survival needs, waste products that need continuous removal for life to continue, but they are not as adept in dealing with age-related changes

For more background on this:

The liver and kidneys work in tandem to detoxify and eliminate waste, toxins, drugs, xenobiotics and their metabolites, this constant detoxification is essential for survival, as exemplified by the fatal consequence of missing liver or kidney functions.

Nonetheless, there are other types of harms associated with aging, that accumulate over decades, which our liver, kidneys, or even immune system are not equipped to handle. The reason is that these are not changes that threated survival, hence evolutionary processes did not take care of these; similar to how aging is there since evolution does not care to optimize for longer life.

[Bryan Johnson @bryan_johnson]

Completed my first total plasma exchange (TPE). Removing all the plasma in my body and replacing with Albumin.

This is different from what I did last year: removing 1 L of plasma from my body and then replacing it with 1 L of plasma from my blood boy @talmagejohnson_ . I gave my one liter of plasma to my father.

This time around there's no blood boy involved.

TPE removes all of my body’s plasma and replaces it with Albumin. The therapy objectives are to remove toxins from my body. The evidence is emergent.

Others use TPE for autoimmune disorders, blood disorders, neurological conditions, transplant-related complications, and replacement of missing plasma components.

As we normally do, we completed a bunch of baseline measurements before this therapy including toxins but other things too such as speed of aging, organ ages, microplastics and many other biomarkers. I'll do six total treatments.

The operator, who’s been doing TPE for 9 years, said my plasma is the cleanest he’s ever seen. By far. He couldn’t get over it. When we finished, he couldn’t bring himself to throw it away. He was imagining all the good that it could do in the world.

On people’s face as PRP therapy. In their body, rejuvenating organs. There is probably a path to auction off or donate my plasma on this next go around. Liquid gold.

Remember that when my father received 1 L of my plasma his speed of aging dropped by 25 years and stayed that way for six months. We don’t know if it was from my super plasma or if it was from removing his plasma, but the results are interesting nonetheless.

The whole procedure took just under 2 hours.

[Bryan Johnson @bryan_johnson]

Extends the medium lifespan of male mice by 22.5% and 35% in female mice.

It's a few years old, I posted about it in 2024.

Showed IL-11 as a driver of aging, and tissue inflammation and fibrosis. It climbed up with age, and was linked to fat build up and muscle loss.

It is now in Phase II human clinical trials for lung fibrosis.

[Bryan Johnson @bryan_johnson]

Blood draw today to create clones of myself and measure biomarkers for magic mushroom follow up.

On my organoid clones:
Blood sample collected for PBMCs, which will be reprogrammed into induced pluripotent stem cells (iPSCs) to generate thousands of mini-livers and hearts. these organoids will be used for high-throughput screening of my longevity protocols. Goals are:

+ creating a digital avatar for drug/supplement distribution, metabolism, and toxicity.

+ detecting and eliminating hidden toxicities.

+ optimizing dosage and intervention combinations for maximum efficacy and minimal risk.

My PBMCs will be isolated for iPSCs. The remaining sample will be used for critical pre-protocol tests:

+ virus screening: HIV, HBV, HCV, virus testing, to ensure my cells and organoids are pathogen free and safe to work with.

+ liver function (LIV): Including enzymes (ASL/ALT), albumin, bilirubin, and CRP (systemic inflammation) to quantify liver health and function. These factors will feed into my digitalI avatar.

+ genetic CYP450 testing: To determine the type and speed of drug, supplement, and xenobiotic metabolism (e.g., CYP1A2 for caffeine, CYP2D6 for beta-blockers).

For magic mushroom follow up:
We are quantifying the effects one week post 25 mg psilocybin dose, specifically measuring:

+ relative telomerase activity and telomere length: a recent study showed psilocybin extended telomere length in human fibroblasts in cell culture. While telomere length increases take 4-6 weeks to become detectable, we are testing for an immediate increase in telomerase activity (the enzyme that regenerates telomeres) in white blood cells.

+ epigenetic markers: my epigenetic speed of aging, organ epigenetic age, and methylome epigenetic biomarker proxies.

+ serum proteome: panels measuring core aging, disease risk/protection

[Benjamin Bikman @BenBikmanPhD]

A big part of that mixed picture is insulin. Chronic rapamycin inhibits mTORC2 as well as mTORC1, and losing mTORC2 impairs insulin's ability to shut down glucose production in the liver. In mice, the lifespan benefit came from mTORC1 and was separate from the insulin resistance, but continuous dosing in a person brings both.

[Sama Hoole @SamaHoole]

The scan that finds cancer works by injecting radioactive sugar, because a tumour takes up more of it than the tissue around it.

Most cancer cells burn sugar the wasteful way, like yeast, so they need far more of it than healthy cells to keep growing.

The tracer is a fake sugar the cell swallows and cannot finish, so it gets trapped inside and glows.

On the screen, the cancer lights up from eating it.

The day before the scan, the patient is put on a low-carb, no-sugar diet.

If their blood sugar is still too high on the morning, the scan can be cancelled, because the sugar already in the blood would hide the tumour.

The hospital knows exactly what the tumour wants, and keeps it off the menu for one day.

Then Britain's biggest cancer support charity raises its money with coffee mornings full of cake.

Channel 4 raises money for Stand Up To Cancer with a celebrity Bake Off.

America's biggest breast cancer charity once sold pink buckets of fried chicken with KFC.

The tea trolley on the chemo ward comes round with biscuits.

Medicine finds the tumour with sugar, then holds a bake sale to fight it.

[Rusty ⚡️: Solar Powered ☀️ @ze_rusty]

Infrared light from the sun expands the structured water inside your cells by 3.7x in 10 minutes

Creating a -200 mV battery.

INSIDE YOU.

Your body is a light-charged battery & you’re living under LEDs that emit zero infrared?

Change that..

Go outside often and switch your bulbs to Incandescents, TODAY!

[小樱💞｜实用工具分享 @xiaoying_eth]

长寿计划公开

Bryan Johnson 每年烧掉 200 万美元抗衰老

但真正关键的，是他免费开放了一份长寿操作手册📄

👇普通人也能照着做的一套蓝图（建议收藏）🧵

[George Ferman @Helios_Movement]

Feeling anxiety physically without anxious thoughts for example, can be a common sign of histamine intolerance/MCAS.

While the average person still thinks that histamine is just something related to allergies, let’s not forget that histamine acts as a neurotransmitter in the brain, influencing things such as arousal, attention, mood, sleep, and motivation.

So when levels build up it can create:

-Restlessness and physical + mental hyperactivity

-Difficulty concentrating, brain fog, inattention

-Irritability, impulsivity, or agitation

-Sleep disturbances (insomnia or poor sleep quality)

-Anxiety or sensory sensitivities

-Hyper arousal

-Racing thoughts, anxiety/panic, or restlessness

-Insomnia or disrupted sleep cycles (common in manic phases)

-Depressive symptoms (fatigue, brain fog, low motivation) during crashes

-Emotional lability or energy fluctuations

Of course, we don’t pull all these out of our asses.

There are reports noting that histamine flares can mimic manic/depressive episodes, and MCAS patients sometimes receive initial bipolar diagnoses.

More:

[Bryan Johnson @bryan_johnson]

Until I was 40, I kind of destroyed my skin.

Sunburns, poor diet, no skincare routine...

Now I'm paying the price.

Here's what I'm doing now and what I wish I'd known earlier in life... 🧵

[wu Yan 吴 衍 @mmmmmsehbt]

@tenschik @Harshit91697036 @SinghJyotirmai 并不是这么简单的理解，他存在和亚伯拉罕沙漠教相似的极度排他性

[Dalton (Analyze & Optimize) @Outdoctrination]

SIBO 101 (& how to finally fix the bloating, gas, and brain fog):

SIGNS YOU MIGHT HAVE IT:

➞ Bloating within 30 min of eating
➞ Symptoms worse 1-3 hours after meals
➞ Belching + upper GI bloating
➞ Coated / white tongue in the morning
➞ Lots of gas from onions, garlic, broccoli
➞ Energy crash after lunch
➞ Brain fog

WHICH TYPE:

➞ Bloating + diarrhea → Hydrogen SIBO
➞ Constipation → Methane SIBO
➞ Rotten egg gas (esp after garlic, onion, meat) → Hydrogen sulfide SIBO

WHAT CAUSES IT:

➞ Slow motility (the MMC is supposed to sweep bacteria out between meals)
➞ Low thyroid (slower motility, fewer enzymes, weaker gut immunity)
➞ Low stomach acid + enzymes
➞ Low B1 + poor vagal tone
➞ Excess unabsorbed iron feeding bacteria
➞ GLP-1 drugs (they work by slowing motility)
➞ Stress (enhances gut permeability / skews motility)

WHAT TO AVOID EARLY ON:

➞ High fiber foods
➞ Fermented foods + probiotics if symptoms are severe

FIXING IT:

Keep in mind these steps are not necessarily in order, and this is not a protocol to do everything here. These are tools for certain functions.

If you want to get a plan tailored specifically for your situation, comment PRISM below and I'll DM you how we can get that set up.

Kill the overgrowth:

➞ FC-Cidal + Dysbiocide, 2 caps each 2x/day for 4 weeks (statistically equivalent to rifaximin in a study)
➞ Oregano oil
➞ Allicin
➞ Mastic gum
➞ Pau D’Arco
➞ Berberine
➞ Antibiotics if needed: rifaximin is standard, neomycin+metronidazole often used for methane, other antibiotics like tetracyclines can be useful too.

Get things moving:

➞ Ginger (activates the MMC)
➞ Raw carrot
➞ Magnesium
➞ Coffee (even decaf)
➞ Triphala
➞ Vagal practices
➞ Walking

Support digestion:

➞ Digestive enzymes
➞ Betaine HCl
➞ Easily digestible diet

Heal the lining (leakiness = oxygen leak = more bacterial growth):

➞ Lactoferrin (100-1,000 mg/day)
➞ Zinc carnosine
➞ Glutamine
➞ Colostrum
➞ Butyrate

Fix the root cause:

➞ Thyroid + mitochondrial function
➞ B1
➞ Vitamins A, D + K2
➞ Chronic stress

Rebuild

➞ Probiotics (S. boulardii, spore-based) once you’ve made progress. They work WITH antimicrobials, not against them.

Often it’s less about killing bacteria and more about restoring the metabolism that keeps them in check.

[wu Yan 吴 衍 @mmmmmsehbt]

@Harshit91697036 @SinghJyotirmai 中国一部分人把马克思主义称为亚伯拉罕第四教并认为它严重破坏了汉文明

[Dalton (Analyze & Optimize) @Outdoctrination]

Gut healing supplements tier list:

S tier:

➤ Lactoferrin
➤ Zinc carnosine
➤ Butyrate / tributyrin
➤ Glutamine

A tier:

➤ Colostrum
➤ Triple therapy probiotics (spore based, S. boulardii, L/B all in one)
➤ Glycine / collagen / bone broth
➤ Vitamin D
➤ Dysbiocide + FC-Cidal
➤ Human milk oligosaccharides
➤ Digestive enzymes
➤ C Butyricum MIYARI

B tier:

➤ Pau d’Arco
➤ Oregano oil
➤ Allicin (garlic)
➤ Spore based probiotics
➤ Taurine
➤ Mastic gum
➤ L. Reuteri
➤ PHGG

C tier:

➤ Niacinamide (Candida)
➤ Betaine HCl
➤ Berberine
➤ Lacto / bifido probiotics
➤ S Boulardii
➤ Caprylic acid
➤ Vitamin K2
➤ Triphala
➤ DGL
➤ Psyllium
➤ Magnesium

D tier:

➤ Cascara
➤ Flowers of sulfur
➤ Activated charcoal / binders
➤ Aloe
➤ DAO
➤ BPC-157

This is based off of my opinion from working with hundreds of clients and hearing hundreds of more peoples' stories, what tends to move the needle the most, ON AVERAGE.

This is NOT me saying one is necessarily better FOR YOU or in a given situation. A D tier can easily outperform an S tier in any given context.

[George Ferman @Helios_Movement]

Here's a list of some cool health facts you might not be aware of:

-Colostrum is 3 times more effective than the flu vaccine.

-Giving hospitalized COVID-19 patients 30,000 IU of vitamin D daily for 3 days reduced their risk of death by 67%.

-Taking ibuprofen for more than 60 days in a year makes men twice as likely to experience infertility.

-66.5% of bankruptcies in the US are due to medical bills.

-Mold exposure can lower the IQ of children by 10 points.

-Nattokinase can reverse carotid artery plaque by 36% at 10,800FU (taken over a year).

-Bright night light exposure is independently associated with type 2 diabetes.

-SSRIs can suppress melatonin by almost 50% under normal light conditions.

-Extending sleep by just 1.2 hours "offsets" 300 extra calories.

-The more you increase sodium fluoride, the dumber kids become.

-Exercise (aerobic) is more effective than SSRIS.

-If 15% of your daily caloric intake comes from sugar, you are 21% more likely to become depressed.

-The sauna is more effective than SSRIs and exercise for depression.

-You can become literally insane if you change your gut microbiome enough.

-Binaural beats at 20 Hz have shown a 27% improvement in word recall.

-Finasteride increase your risk of depression quite a lot.

-Stress can make you diabetic.

-Morning sickness is a sign of a healthy pregnancy.

-People with ADHD have smaller pineal glands.

-3 days of forest bathing can increase natural killer cell activity by almost 50%.

-Artificial blue light increases your blood glucose levels without you consuming a single calorie.

-Exercising 4 hours after reading something improves retention.

-Creatine is an underrated supplement for lowering triglycerides.

-Negative air ions (think being outside in nature) reduce depression by 50%.

-Thinking that depression is a response to inflammation might be correct in a lot of cases.

-Taurine deficiency causes heart failure.

-Red light might prevent skin cancer.

-ASD is probably the outcome of mitochondrial dysfunction during neurodevelopment.

-Your heart ages VERY fast if you are sedentary.

-By taking 600mg of NAC twice a day during flu season you might drop your chances of getting sick by up to 50% (note, NAC taken for weeks on end will deplete copper and harm some of the biofilms of beneficial gut bacteria)

-Licorice root extract decreases COVID mortality rate by 62% (it's a cool fact, do not start using too much licorice).

-Oral probiotics improve psoriasis.

-240mg twice daily of Fernblock may reduce the risk of sunburn by 400% and UV damage by over 300%.

-Bile treatment improves psoriasis.

-Lithium in drinking water is associated with far fewer su*cides.

-Using a smartphone for 60 minutes a day lowers fertility and testosterone quite a lot.

-Vapes can contain up to 20 times more lead than cigarettes.

-Laughter reduces cortisol levels by up to 37%.