mohsin 🕊️

founder @dormillo

[Andrej Karpathy @karpathy]

This is a super exciting release - Claude Fable 5 is the same underlying model as Mythos but with added safeguards. The benchmarks are great and it's SOTA on everything by a margin but I'll add that *qualitatively* also, this is a major-version-bump-deserving step change forward (imo of the same order as Claude 4.5 was in November), peaking especially for long problem-solving sessions on very difficult problems. You can give it a lot more ambitious tasks than what you're used to, the model "gets it" and it will just go, and it's never felt this tempting to stop looking at the code at all (but don't do this in prod!). The model still has quirks that people will run into and the safeguards are configured to be a little too trigger happy for launch, which can hopefully be tuned over time.

I feel a lot of things changing as working software increasingly comes out on a tap. The Jevon's paradox kicks in and I feel my own demand for software growing substantially. You can ask for anything - explainers, visualizers, dashboards, bespoke single-use apps (e.g. a full wandb that is hyper-specific just for your project), you can 10X your test suite, auto-optimize code, run giant research projects with custom HTML for the results, anything! "Free your mind" (Matrix ref). Really looking forward to all the things people build!

[1001Tracklists Media @1001TLtv]

Josh Baker & Joseph Capriati closing the Amnesia opening party ☀️🕺

[DannyKayIbiza @DannyKayIbiza]

Epic Opening Party @Amnesia_Ibiza last night with the carry on today at the island's most beautiful club @esparadisibz

50 Years of Dancing #ibiza2026

[jesse.base.eth @jessepollak]

it’s great to see ethereum scaling L1 - this is a win for the entire ecosystem.

going forward, L2s can’t just be “ethereum but cheaper.” that's why from the beginning of base we've shown up everyday to onboard new users, developers, and apps, push the technology forward, and do it all in a symbiotic way that grows the entire ecosystem.

we’ve benefited deeply from building with ethereum - by leveraging its security and infrastructure, we've been able to focus: on building the best products and unlocking new real use cases across trading, social, gaming, creators, predictions, and so much more. We reached stage 1 last year and are accelerating towards solving the technical complexities of safely reaching stage 2.

base is going to keep driving hard towards our mission: building a global economy that increases innovation, creativity, and freedom. to do that, we're already leaning into the kind of differentiation vitalik is talking about here, and have been supported by the EF in doing so: building the best apps, native account abstraction, privacy, scaling, and more.

excited to work with ethereum to build the onchain future we all believe in.

[KJ Dhaliwal @kjdhaliwal]

how @lotus works:

ask anything, anytime

- Lotus checks your unified medical records + wearables + insurance (HIPAA aligned, encrypted, never shared)
- the latest medical evidence + clinical guidelines
- real doctors review and oversee care

[Chubby♨️ @kimmonismus]

So lets be clear:

This massive medical study revealed the following:

AI added led to 29% more cancer detected, 44% reduced workload, and less cancer dx in subsequent 2 years, and, when found, less aggressive

Doctors who do not use AI nowadays are acting with gross negligence. Its should be mandatory by now.

[Boris Cherny @bcherny]

@altryne All of it

[Claude @claudeai]

In Cowork, you give Claude access to a folder on your computer. Claude can then read, edit, or create files in that folder.

Try it to create a spreadsheet from a pile of screenshots, or produce a first draft from scattered notes.

[Greg Brockman @gdb]

Introducing ChatGPT Health: https://t.co/HnzAoH6UtV

[Pietro Schirano @skirano]

Claude Code isn’t just for coding.

I fed it my raw DNA data from an ancestry test and used it to find health related genes I should keep an eye on.

The file is massive, but its ability to search what matters makes it possible.

[Elon Musk @elonmusk]

@Yuchenj_UW 2026 is the year of the Singularity

[Computer @AskPerplexity]

Every transformer since 2015 has the same residual design — one stream carrying information between layers.

DeepSeek figured out how to widen it without training collapsing:

https://t.co/zfvPHtzrim

[Boris Cherny @bcherny]

When I created Claude Code as a side project back in September 2024, I had no idea it would grow to be what it is today. It is humbling to see how Claude Code has become a core dev tool for so many engineers, how enthusiastic the community is, and how people are using it for all sorts of things from coding, to devops, to research, to non-technical use cases. This technology is alien and magical, and it makes it so much easier for people to build and create. Increasingly, code is no longer the bottleneck.

A year ago, Claude struggled to generate bash commands without escaping issues. It worked for seconds or minutes at a time. We saw early signs that it may become broadly useful for coding one day.

Fast forward to today. In the last thirty days, I landed 259 PRs -- 497 commits, 40k lines added, 38k lines removed. Every single line was written by Claude Code + Opus 4.5. Claude consistently runs for minutes, hours, and days at a time (using Stop hooks). Software engineering is changing, and we are entering a new period in coding history. And we're still just getting started..

[shyamal @shyamalanadkat]

bet on people with insane learning curves.

[Andrej Karpathy @karpathy]

Agency > Intelligence

I had this intuitively wrong for decades, I think due to a pervasive cultural veneration of intelligence, various entertainment/media, obsession with IQ etc. Agency is significantly more powerful and significantly more scarce. Are you hiring for agency? Are we educating for agency? Are you acting as if you had 10X agency?

Grok explanation is ~close:

“Agency, as a personality trait, refers to an individual's capacity to take initiative, make decisions, and exert control over their actions and environment. It’s about being proactive rather than reactive—someone with high agency doesn’t just let life happen to them; they shape it. Think of it as a blend of self-efficacy, determination, and a sense of ownership over one’s path.

People with strong agency tend to set goals and pursue them with confidence, even in the face of obstacles. They’re the type to say, “I’ll figure it out,” and then actually do it. On the flip side, someone low in agency might feel more like a passenger in their own life, waiting for external forces—like luck, other people, or circumstances—to dictate what happens next.

It’s not quite the same as assertiveness or ambition, though it can overlap. Agency is quieter, more internal—it’s the belief that you *can* act, paired with the will to follow through. Psychologists often tie it to concepts like locus of control: high-agency folks lean toward an internal locus, feeling they steer their fate, while low-agency folks might lean external, seeing life as something that happens *to* them.”

[🍓🍓🍓 @iruletheworldmo]

this is insane. a reminder that we are not slowing down. no wonder people are calling claude agi for devs.

[Jemima Goldsmith @Jemima_Khan]

A personal plea to @elonmusk
My two sons have not been allowed to see or speak to their father Imran Khan who has been held unlawfully (acc to the UN) for 22 months of solitary confinement.
X is the only place left where we can still tell the world he is a political prisoner without basic human rights.
Yet every time I post about him, the reach inside Pakistan (and often globally) is throttled to almost zero.
You promised free speech, not “speech but no one hears it”.
Please fix the visibility filtering on my account so we can get the message out! @MarioNawfal

[UN Special Procedures @UN_SPExperts]

#Pakistan: Imran Khans solitary confinement and inhumane detention conditions must end - UN expert. Prolonged or indefinite solitary confinement is prohibited under int'l human rights law – and when it extends longer than 15 days, it's a form of #torture.
https://t.co/m2Re8Yhyc0

[Sam Altman @sama]

It is a very smart model, and we have come a long way since GPT-5.1:

[Chubby♨️ @kimmonismus]

here we go: Claude Opus 4.5 official, SOTA Benchmark evals, but more importantly: much cheaper than Opus 4.1!