Molecular and Cellular Biochemistry

Exploring the latest research advancements in the field of Biochemistry

[NatureStructMolBiol @NatureSMB]

ESKAPE velocity: total synthesis platforms promise to increase the pace and diversity of antibiotic development. News & Views by Jacob Mattingly & @Dunham_Lab @DunhamLabEmory @emoryuniversity on a recent paper in @Nature https://t.co/IDHvtN8EN3

[Nature Biotechnology @NatureBiotech]

Generating lineage-resolved, complete metagenome-assembled genomes from complex microbial communities https://t.co/2kxJhxNsAG

[Science Magazine @ScienceMagazine]

A recent #ScienceReview looked at research that shows how bacteria, viruses and fungi of the microbiome are pervasive among human cancers, are key actors in cancer immunotherapy, and are potentially engineerable to treat metastases. Learn more: https://t.co/Wq9Kps2k5h

[Nature Biotechnology @NatureBiotech]

Off-the-shelf allogeneic approaches can potentially treat thousands of patients from a single batch of engineered CAR-T cells instead of having to make an individualized therapy for each patient. But those gains in cost, speed and utility come at a price https://t.co/X7YuuwHgfj

[NatureStructMolBiol @NatureSMB]

#CryoEM work by Greiwe, Costa, Diffley &al @TheCrick shows how DDK selectively targets DNA-loaded MCM helicase to trigger #replication origin activation. Checkpoint kinase Rad53 blocks origin firing by impairing double hexamer engagement by DDK #openaccess https://t.co/swfSxYGKYv

[Science Magazine @ScienceMagazine]

Not only do catnip and silver vine hold a special place in felines’ hearts, research from @ScienceAdvances finds the intoxicating chemicals in these plants also protect cats from mosquito bites. https://t.co/9bkWc0avHG

[eLife - the journal @eLife]

📅 December #12DaysOfeLife

Genetic analyses recently revealed almost a thousand genes used only by the human uterus. https://t.co/eVWTl568Tg

[Science Magazine @ScienceMagazine]

Side effects of #SARSCoV2 vaccines are often troubling but may merely reflect transient production of type I interferons, a normal immune reaction to contact with pathogens. Read more in @SciImmunology: https://t.co/bkMPQVEBNE

[Nature Biotechnology @NatureBiotech]

Virtual meetings promise to eliminate geographical and administrative barriers and increase accessibility, diversity and inclusivity https://t.co/IzqnZBHAso

[eLife - the journal @eLife]

Removing a key protein from the worm Caenorhabditis elegans near the end of its life can double the worm’s lifespan, demonstrating that life-extending interventions can be made at any age. https://t.co/aP90coCblL

[Science Magazine @ScienceMagazine]

Only 1.5% to 7% of the modern human genome is uniquely human, according to a @ScienceAdvances analysis of Neanderthal, Denisovan, and human genomes. https://t.co/atRxtnBYKx

[Science Magazine @ScienceMagazine]

Pregnancy and fetal sex influence the quality of antibody responses to #SARSCoV2 infection and immunization, argues a new @ScienceTM Focus article. Read more: https://t.co/xrXUjEUYjT

[Science Immunology @SciImmunology]

Intracellular complement signaling in human and mouse #macrophages controls inflammatory response in #atherosclerosis models, a new study reports. https://t.co/Dq38Mh3sbr

[Science Magazine @ScienceMagazine]

A new method developed to reread a single polypeptide many times overcomes one of the biggest obstacles toward single-molecule proteomics.

Read more in a new #SciencePerspective: https://t.co/H5iI1ABOcD

[Nature Biotechnology @NatureBiotech]

Investment in small-molecule protein degraders is surging, but their drawbacks, limitations and risks are becoming clear. Ken Garber investigates the PROTAC gold rush https://t.co/iINCqITjEN

[eLife - the journal @eLife]

📅 August #12DaysOfeLife

A structural model of the SARS-CoV-2 spike protein as the virus fuses with host human cells revealed an opportunity to disrupt dynamics and halt transmission.
https://t.co/jmm0zQYWWL

[Science Immunology @SciImmunology]

In mice, IL-25 and CysLTs proteins from airway #TuftCells cooperate to drive #Allergen inflammation in the lungs, say @BrighamWomens @HarvardMed researchers. https://t.co/VYiUtZAoze

[Science Magazine @ScienceMagazine]

The impacts droughts will have on features like carbon and water fluxes in tropical forests are a little clearer thanks to a study in an enclosed experimental forest ecosystem.

Learn more ⬇️

#ScienceResearch: https://t.co/ix6lBrUH3V
#SciencePerspective: https://t.co/Pe768NxiWV

[NatureStructMolBiol @NatureSMB]

#ICYMI: The discovery that mRNA degradation & deadenylation are uncoupled during meiosis in budding yeast reveals that transcript length is a determinant of deadenylation rates across eukaryotes. @Dawiener5 @yaronantbi @SchragaSchwartz @WeizmannScience https://t.co/VfOYiEfb0V

[Frontiers - Immunology @FrontImmunol]

New Research: The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier: The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are… https://t.co/3TBBZB14Vk #immunology