Plasminogen Degradation by Neutrophil Elastase in Pleural Infection, Not High Plasminogen Activator Inhibitor 1, Is the Cause of Intrapleural Lytic Failure - CHEST https://t.co/gk0khuHSnq
@ChrisBarrettMD@HBuMoore
Moore et al. show during LPS-induced #inflammation, there are distinct populations of interstitial macrophages with unique functions. Folate Receptor β+ IMs = stable resident population. FRβ- ΙΜs = mixed population of resident & recruited IMs https://t.co/iUK4lo6b0Z
@MoorePeterK
@rabihmgeha @DxRxEdu I would add pulm htn to vascular, obesity to increased A-a (microatelectasis) and neuromuscular to normal A-a (when hypoventilation from low Vt causes hypoxemia). Not sure how crazy you want to get with filled alveoli: lymphocytes, eosinophils, lipid, protein, calcium
Testing for blood clotting abnormalities reveals which critically ill COVID-19 patients are at risk for thrombotic events and need hemodialysis.
https://t.co/tYlgc6GdLx
#ACSCOVID19#COVID19surgery@AmCollSurgeons
The NIH is looking for volunteers to quantify undetected cases of the coronavirus. They will send you an at-home blood collection kit and you can send it back to them to see if you have antibodies to the virus. Consider registering
https://t.co/tpJmAZymaO
Wrong question: "Should we treat #COVID19 like ARDS or not?"
A (slightly) better question: "What is the prevailing microvascular phenotype that will guide the best treatment for our patient's respiratory failure?" A work in progress with @RogerAlvarezDO:
@rabihmgeha@k_vaishnani This is awesome Rabih! Idiopathic pulmonary hemosiderosis is tricky to categorize- I agree that vasculopathy is most accurate but may be inflammatory as steroids are the mainstay of treatment and it is associated with autoimmune diseases (like celiac)