Scott Matson

Pulm/ccm doctor interested in ILD and pragmatic trial design

[ATS Blue Journal @ATSBlueEditor]

Decoding Molecular Heterogeneity in Idiopathic Pulmonary Fibrosis
@atscommunity

🔗 https://t.co/hlMrD9ll7X

[Scott Matson @scott_matson]

Tough week on NIH funding front, R21 that scored 8% was “not funded” on Monday and second grant was “not discussed” this weekend. I’m undeterred, “the obstacle becomes the way,” but also

[Scott Matson @scott_matson]

@DrPujaMehta1 Def! Have left and right equal with laptop below and centered is a set up

[Scott Matson @scott_matson]

Small cohort but promising findings as an approach to cluster and classify groups of idiopathic and autoimmune ILD patients across the spectrum of inflammation and fibrosis @KaminskiMed @KerriBerriKerri @DrPujaMehta1 @EBRheum @aravindamenon @drdayjee @IPFdoc

[Scott Matson @scott_matson]

Excited to share the first paper from the Matson lab! Here we used label free quant proteomics of the lung microenviron (BALF) to ID molecular clusters across IPF and IPAF. Clusters had unique survival trajectories and outperformed GAP index.

https://t.co/ZpDst6hecG

[Scott Matson @scott_matson]

@JulesBass6 Agreed! My little dudes make my day so efficient, knowing that I have the time between dropoff and pick up to get everything done including exercise brings the priorities of my work and day so clearly into focus!

[Scott Matson @scott_matson]

@DrPujaMehta1 @IPFdoc They almost got there too, like right on the edge of realizing they were just echoing around the same idea amongst the same 20 loud voices, then they backed away back to safety inside the chamber

[Scott Matson @scott_matson]

@DrPujaMehta1 @SophieGooner @stylenat_ Hahaha! It gets worse

[Scott Matson @scott_matson]

@JayCuda @royalsreview @dlow1213

[CU Anschutz Hematology/Oncology Fellowship @CUHemeOnc]

Big congratulations to our former HemeOnc fellow and current Assistant Professor, Medicine-Medical Oncology, Dr. Tejas Patil! #CUDeptMedicine #CUCancer #CUAnschutz

[Sen. Bernie Sanders @SenSanders]

Three months after launching our investigation into the outrageously high cost of inhalers in this country, three major manufacturers agreed to cap their costs.

Soon, the vast majority of Americans with asthma and COPD will pay no more than $35 for their inhalers.

[Scott Matson @scott_matson]

@IPFdoc @KaminskiMed @KerriBerriKerri @MartinLandray There are some examples like hepatocellular carcinoma where the randomized clinical efficacy studies survival benefit far outperformed real world survival in follow-up observational studies because people in trials aren’t the same as seen in clinic.

[Scott Matson @scott_matson]

@IPFdoc @KaminskiMed @KerriBerriKerri @MartinLandray Non random comparisons are fraught, I think there’s value in retrospective studies of treatment outcomes, the ground truth of what happens on a particular treatment is ground truth, but yes data suggesting causal inference when comparing non randomly selected txtmts is useless

[Scott Matson @scott_matson]

@DrPujaMehta1 @AWIRGROUP @hugh_montgomery @gwenesta_melton @noellealicia242 @EBRheum @leticiakawano @KerriBerriKerri @KaminskiMed @katerinantoniou @smlungpathguy @jeffsparks Love it! One should probably be okay going even further than exoneration and be thankful for all the RA lung disease that MTX has prevented! Good RA drugs = good dx control = lots of patients that never developed clinically meaningful disease

[Scott Matson @scott_matson]

@KaminskiMed @IPFdoc @KerriBerriKerri It does appear that the only treatment these patients could receive was immunosuppression, so comparing treated vs non treated patients means “treatment” likely just selects for the worse and more progressive group rather than telling us anything about the impact of treatment

[Mike Putman @EBRheum]

Thanks for participating! Really enjoyed the conversation

Great thoughts on risk/benefits of screening, ideal mgmt for pts w/ILD, importance of detection, etc

Have a listen! Links: https://t.co/PzEDiBdc9P

[Scott Matson @scott_matson]

@jeffsparks @DrPujaMehta1 @KerriBerriKerri @leticiakawano

[Scott Matson @scott_matson]

I had a ton of fun with this discussion here, happy to be invited to join @RheumILD to debate screening in RA ILD on Evidence Based Rheum podcast with @EBRheum!!

https://t.co/RhzG1f2IpS

[Jeffrey Sparks MD MMSc @jeffsparks]

Our editorial about the bi-directional association of RA and COPD

Fun to write this with Dr Julia Ford (previous @BrighamWomens fellow and now U of Michigan faculty) and @mikecho95

Each disease are risk factors for the other, NOT explained by smoking

https://t.co/0yBLCChpKi

[Kristen Demoruelle @KDemoruelle]

See our new collaborative study that found elevations of peripheral Tph cells in pre-RA #rheumatoidarthritis @CURheumatology https://t.co/w7IWK235ng