Dean

Comments and opinions are my own. I don’t believe everything I say and you probably shouldn’t either. Endovascular to Neuromodulation to MCS

[Dean @mrdeanm]

@MatthewBerman @bot Is this real life?

[frank arko @farkomd]

Another Aorta Replaced. Happy to take questions

[Andrew J Sauer MD @AndrewJSauer]

Our recent online publication in @JACCJournals is relevant for clinicians because it advances a distinct, mechanistically targeted paradigm for acute decompensated heart failure (ADHF): mechanical preload regulation rather than further pharmacologic escalation.

In the multicenter, prospective VENUS-HF early feasibility experience (n=60), the next-generation preCARDIA system, designed to intermittently regulate superior vena cava (SVC) flow (roughly ~30% of venous return), was deployed and removed successfully in 100% of treated patients, with 98.3% freedom from device/procedure-related major adverse events, supporting a credible safety and real-world technical feasibility signal across diverse operators and sites.

By design, SVC-based preload reduction aims to lower right- and left-sided filling pressures without the abrupt hypotension risk seen with inferior vena cava occlusion, and the study’s physiologic results align with that premise: among patients treated for approximately 24 hours, right atrial pressure and pulmonary capillary wedge pressure fell substantially (with paired reductions persisting shortly after device removal), while urine output and net fluid output increased during support, suggesting a potentially meaningful lever on venous congestion/cardiorenal physiology in a population already receiving high-dose diuretics.

Taken together, we propose systems like the preCARDIA approach as a scalable hemodynamic unloading platform with small-profile iterations (14F to 10F) and reproducible deployment that could fill a long-standing innovation gap between diuretic-centric care (often limited by diuretic resistance and renal dysfunction) and more invasive or mixed-evidence decongestive strategies (such as ultrafiltration), while providing the rationale and design foundation for larger trials to determine whether targeted mechanical preload reduction can translate physiologic unloading into improved clinical outcomes such as faster, more complete decongestion and fewer rehospitalizations.

Check out the paper here:
https://t.co/nht1rB1SGw

[Dean @mrdeanm]

@Buckingham_Show Are you a candidate for temporary mechanical circulatory support or other supportive therapies?

[Dean @mrdeanm]

@zolfagariMD Hey dude, we got a request from someone with your name using a Facebook profile to join a relatively niche group for dad‘s married to doctors and there are two Facebook profiles with the exact same name and picture of different follower amounts. Can you DM me? Was this you?

[Dean @mrdeanm]

@GavinNewsom Would have been better served in the French Laundry or perhaps a luxury box in Los Angeles.

[Dean @mrdeanm]

@girdley Ray Cohen did this at Axonics for a very large team. Great guy, very successful and getting companies over the finish line and acquired.

[Dean @mrdeanm]

@girdley Does chef do the shopping?

[Dean @mrdeanm]

@EM_RESUS Being kind gets you most of the way there most of the time. Following-up is usually enough after that.

[Dean @mrdeanm]

@realEstateTrent Get an Au Pair

[Dean @mrdeanm]

@kidneymo Congratulations to you on taking this step and your willingness to continue focusing on a serving others. A true testament to doing right for others. I hope your time in Egypt is better than you hope it is!

[Dean @mrdeanm]

@crypto_bitlord7 I remember when XRP pumped in 2018 and then it fed most of that back into the market. Macro bullish.

[Dean @mrdeanm]

@infosec_fox power, printer, serial (mouse), monitor, USB, mouse/keyboard, modem, lock.

late 90s/early 2000s?

[Dean @mrdeanm]

15 years of feeding data to the algorithm and it still gets targeted ads wrong. #MyXAnniversary

[Dean @mrdeanm]

@RatWaste44 Ugly truth about them and others is that they tend to be accurate on valuation, whether or not they’re factually accurate they correctly identify overvalued companies more often than not

[Sam Ghali, M.D. @EM_RESUS]

Farmers be like: “I would’ve come in sooner but I didn’t wanna bother you guys.”

Their ECG:

[Dean @mrdeanm]

@NoobieDog I don’t code but the hard codes admin password stood out to me

[Dean @mrdeanm]

@realEstateTrent I got the friends parents phone numbers and message them. There’s a balance here. On the whole, social media is largely harmful to kids for a variety of reasons. Using a phone to coordinate real-life meet ups is probably one of the few healthy use cases.

[Dean @mrdeanm]

@CollinRugg The bullet had .15 seconds to travel from the barrel to Trump’s head, the average human reaction time ~.2 seconds.

So the same guy that allegedly is in relatively poor health and isn’t particularly quick also has better reaction time than an F1 driver? Doesn’t check out.

[Dean @mrdeanm]

@anothercohen @moatgoatz Minnesota is a mecha for biotech / MedTech / tons of great economic opportunity there.