@jryckman3 Agree here on your concerns about differences in baseline characteristics given the secondary analyses of CREST
👉 extent of extrathoracic disease?
👉 use of elective nodal irradiation?
👉 large volumes irradiated (outliers?)
@jryckman3 My radiology department asked just the week before ESTRO if we could upload RT plans with dose distribution and structure sets to PACS. They eagerly wanted to evaluate the CT with that information available
Danish #breastcancer partial breast #radiotherapy “natural” trial.
➡️ No postoperative treatment had highest risk of recurrence
➡️either tamoxifen or #radonc reduced recurrence
➡️combined tamoxifen + RT had no recurrences
In context of EUROPA trial, RT has best QoL vs endocrine Tx
Those who pray are aware of their own limitations; they do not kill or threaten with death. Instead, death enslaves those who have turned their backs on the living God, turning themselves and their own power into a mute, blind and deaf idol (Ps 115:4–8), to which they sacrifice every value, demanding that the whole world bend its knee. Enough of the idolatry of self and money! Enough of the display of power! Enough of war! True strength is shown in serving life. #Peace
🔔 The European Medicines Agency's CHMP has issued positive recommendations for two new treatment options in ES-SCLC — a disease where our patients have historically faced very limited options and poor prognosis.
⭕ Tarlatamab by @Amgen
A bispecific T-cell engager (BiTE) now recommended for relapsed ES-SCLC, addressing a clear unmet need for patients who have progressed after prior therapy.
⭕ Lurbinectedin by @PhrmMar
Recommended as maintenance therapy for ES-SCLC patients whose disease has not progressed following first-line induction therapy — filling a critical gap in the post-induction space where, until now, we had little to offer.
Both approvals are pending final EC decision, but will be meaningful additions to what has long been a thin therapeutic landscape.
https://t.co/DKy4yGTJtm
@peters_solange@LuisPaz_Ares@HosseinBorghaei@DrRoyHerbst@MartinReck2@g_mountzios@StephenVLiu@charlesrudin@JulienMazieres@teekayowo
🔬 Should histology preclude comprehensive molecular profiling in squamous NSCLC?
We present what is, to our knowledge, the first reported case of a ROS1 fusion-driven metastatic lung squamous cell carcinoma (LUSC)
https://t.co/l2PNDRbU0T
Statement from the Nobel Foundation
One of the core missions of the Nobel Foundation is to safeguard the dignity of the Nobel Prizes and their administration. The Foundation upholds Alfred Nobel’s will and its stipulations. It states that the prizes shall be awarded to those who "have conferred the greatest benefit to humankind," and it specifies who has the right to award each respective prize. A prize can therefore not, even symbolically, be passed on or further distributed.
For additional information, please refer to the Norwegian Nobel Committee: https://t.co/HqL1ZR8Bos
@WhiteHouse Incredible that NATO has been “telling Denmark for 20 years” to fix a “Russian threat” in Greenland—while the U.S. Air Force has literally been stationed there the entire time. Guess everyone just forgot.
Wow USA, this one must hurt!!!
“We do not want to be rich like Americans. Look how greedy they are, even trying to invade their friends. We would not sell ourselves. We know what happened to Indigenous people in Alaska and Native Americans. Their land was taken, and they were not treated well.”
— Greenlandic politician Tillie Martinussen
That is not a throwaway jab, it is a full moral indictment. It flips the usual American self image on its head: wealth is not automatically admired, and power is not automatically respected. When someone says they would rather stay themselves than become “rich like Americans,” they are basically saying the brand is broken, and the history is part of the reason.
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