Mukund Sharma

postdoc @westermarcklab @BioscienceTurku exploring #Epigenetic targets for #Cancer therapy

[Scott Kopetz @skopetz]

Shared some insights on #ctDNA’s power to guide clinical decisions in GI cancers—enabling precision treatment, improved surveillance, and earlier intervention for colorectal cancer patients. Excited by the field’s rapid progress towards personalized care!
https://t.co/dSznBGCkSM

[OserLab @Oser_Lab]

Excited to share our new work in Dev Cell (https://t.co/BjVkuDiBXi), led by my highly talented postdoc Deli Hong! We find that loss of NOTCH2 creates a dependency on TRIM28, highlighting TRIM28 as a potential therapeutic target in NOTCH2-deficient or low-NOTCH2 SCLC.

[Eric Topol @EricTopol]

Is there a basis for very high protein intake, like 1 g per pound per day?

[David Sinclair @davidasinclair]

NEW STUDY: β-hydroxybutyrate is made during exercise, keto & intermittent fasting. Rats treated with the precursor 1,3-butanediol had lower body weight, blood pressure & blood glucose, ostensibly due to chromatin remodeling 👏👏 https://t.co/g2XaVcTnMU

[Yang Zhao @YangZhao102]

Excited to share our @Nature papers exploiting the receptor pairing code to expand the cytokine receptor alphabet in T cells. Nonnatual receptors reprograms T cells into myeloid lineage. Grateful for the amazing collaborators @xrtcell , @MasatoOgishi

[Chad Pecot, MD @ChadPecot]

What’s better than drugging one “undruggable” target? How about drugging 2 at the same time!

Now out in JCI our group reports the development of the first dual KRAS+MYC inhibitor

https://t.co/ydcUUmQKEi

Here are some key highlights 👇

[nature @Nature]

Hidden in the lungs of some breast cancer survivors are tumour cells that can remain dormant for decades — until they one day trigger a relapse

https://t.co/Hy9WDMY6cO

[Di Zhao MDA @Dr_Di_Zhao]

Thrilled to share our latest work published in #NatureCancer! 🥳We uncover the metabolic vulnerability of and develop novel therapy for advanced prostate cancer with SPOP and CHD1 defects! Grateful to my amazing team, collaborators, and supporters! 🙏@MDAndersonNews Read it here: https://t.co/DKrZwn5ew1

[Linghua Wang, MD, PhD @IamLinghua]

📢 Now live at ⁦@Nature⁩
Our team discovered that PPP2R1A mutations are linked to improved response to immunotherapy in ovarian clear cell carcinoma. ⁦@Yibo_Dai⁩ ⁦@AmirJazaeri⁩ ⁦@ZhangLabMDA⁩ ⁦⁦@MDAndersonNews⁩ https://t.co/7hQ7wCqz4e

[Polyak Lab @LabPolyak]

Our study on histone tail cleavage is out today in @NatureGenet . We found KDM4C prevents CTSL-mediated histone H3 tail clipping by modulating its recruiter GRHL2, reducing oxidative stress and promoting basal tumor growth. Congrats to @ZheqiL @nellage
https://t.co/Lllx8afviz

[Mukund Sharma @musharma2602]

🚨 New preprint!

We uncover how phosphorylation at Ser166 of LSD1 acts as a switch between gene repression and activation, controlling the epigenetic landscape and shaping the tumor immune microenvironment in non-hormonal cancers.
#Epigenetics #CancerResearch #LSD1 #PP2A #RAS

[bioRxiv Genomics @biorxiv_genomic]

LSD1 serine 166 is a phosphorylation switch for chromatinlandscaping, gene activation, and tissue remodeling https://t.co/IvTuABxnC4 #biorxiv_genomic

[Fuks_Lab @FuksLab]

Very excited to share our recent paper in @Cell, revealing an elegant mechanism where RNA modification and DNA methylation work together to regulate gene expression and influence differentiation. https://t.co/gIiJgGIlnE

[BioCity Turku @BioCityTurku]

NEXT WEEK Thursday at 12:00, Frontiers of Science seminar in Presidentti, BioCity. Come and listen to Prof. Saverio Minucci from @IFOMresearch when he tells us about cellular responses to genomic stress.
☕️+🥪at 11:45
@BioscienceTurku @westermarcklab @UniTurku @AboAkademi

[Mukund Sharma @musharma2602]

Thrilled to represent the @westermarcklab & present our latest research on #PP2A and #RAS mediated regulation of #KDM1A in #NSCLC at #AACR2024!

[Mukund Sharma @musharma2602]

@_India_Research @westermarcklab @TilmanBrummer Thank you very much for your wishes, Manoj. I appreciate it and hope to catch up with you soon.

[Mukund Sharma @musharma2602]

It's been an incredible journey. Sincere thanks to my mentor Prof. Westermarck @westermarcklab for your incredible supervision and guidance and my opponent @TilmanBrummer for the lively discussion!

[Manoj Saxena @_India_Research]

@musharma2602 @westermarcklab @TilmanBrummer Dear Friend: We've been in school together in India. And both of us now have a PhD thanks to guidance that our supervisors and departments afforded to us, and our own work ethic. My very best wishes to your work on biotechnology. And much partying is definitely due from your side

[Mukund Sharma @musharma2602]

@TilmanBrummer Thank you, Professor Brummer! Your valuable feedback will undoubtedly contribute towards enhancing my understanding of the field."

[Mukund Sharma @musharma2602]

Thank you, Jukka! could not have done it without your support, guidance, and encouragement. Big thanks for being such an awesome mentor and I'm immensely grateful for everything you've done for me.

[Whetstine Lab @WhetstineLab]

~Please Re-post~
Free Hybrid @CeiFccc #Epigenetics Sympoium featuring world-leaders in #academia & #Industry
We aim to allow anyone, anywhere at any educational level to see top-notch science @ a meeting @ least 1 time per year
Free registration- scan QR code
@FoxChaseCancer