Michael V Holmes (he/him)

Pharmaceutical physician & epidemiologist, MD/PhD Genentech. Opinions are my own.

[Anna Hughes @EatSleepCycle]

If anyone would like to join the ride for @TimMcKenna01, please get in touch. It's hard to believe this even happened, but it will be so nice to come together and remember Tim, to ride the way he rode, and raise a few quid for Mind. https://t.co/B2Uu6ejF1R

These are the dates:

[Michael V Holmes (he/him) @mvholmes]

@realDaveFeldman @ethanjweiss @BioLayne @PeterAttiaMD @foundmyfitness @theproof @nicknorwitz And in MR we don’t really compare people above vs at the population average unless we specifically design it that way. It’s an effect scaled to a delta in the exposure. So assuming a linear relationship, an effect can be expressed either way.

[Michael V Holmes (he/him) @mvholmes]

@realDaveFeldman @ethanjweiss @BioLayne @PeterAttiaMD @foundmyfitness @theproof @nicknorwitz Unless there’s a threshold effect or inflection point of the exposure-outcome relationship at the population average, which would be atypical for biomarkers typically associated with disease, it’s usually a reasonable assumption to be able to flip it around.

[Adam Auton @adamauton]

Yesterday was a hard day at 23andMe, and we said goodbye to a number of tremendously talented colleagues. If people have job openings in the genetics space that they'd like me to share with the impacted folks, please do post here.

[Anne Wojcicki @annewoj23]

Thank you to our customers and the @23andMeResearch team for this work on the genetics of #longcovid

https://t.co/1UWyDHuJH6

[23andMe Research @23andMeResearch]

Our blog post on the same work, for the lay reader. https://t.co/bfBWB9KoG3

[Prof. Akiko Iwasaki @VirusesImmunity]

Much-needed data on the genetics of #longCOVID in a new preprint by @23andMeResearch - GWAS of #LongCOVID identified 3 loci pointing to immune and thrombo-inflammatory mechanisms 🔥 @ninaadsc
1) HLA-DQA1–HLA-DQB
2) ABO
3) BPTF–KPAN2–C17orf58
(1/)
https://t.co/0MUr9GbDiA

[Ninad Chaudhary @ninaadsc]

📌Publication alert: In a preprint from the @23andMeResearch team, we conducted one of the largest GWAS study of Long COVID and identified genetic links of chronic conditions with Long COVID.
https://t.co/gbVvbFXJTk

[CEL @CELovegrove]

🚴🏼‍♀️In less than 2 weeks I'll be in the saddle towards Barcelona with @DominicFurniss & some colleagues, friends, & his family. #O2B

Why? To raise 💰for @Sarcoma_UK

Why? Have a look here: 👀https://t.co/utReSxDWIJ

Able to donate? Please do here: 👏🏼https://t.co/5S5pDNX3K7

[Michael V Holmes (he/him) @mvholmes]

Thanks to the fantastic Research Team at 23andMe, with a specific shout-out to Dr Jing Shi who impressively led this project to fruition. 🙌

[Michael V Holmes (he/him) @mvholmes]

In a preprint from the @23andMeResearch team, we used Mendelian randomization to explore the genetically-predicted causal effects of Lp(a) on a range (n=489) of human traits and diseases.
https://t.co/SqwKEU4F3x

[Michael V Holmes (he/him) @mvholmes]

Importantly, levels of Lp(a) are higly genetically regulated, speaking to the need for therapeutics to lower Lp(a) when levels are elevated. This also identifies the value of genetics in identifying individuals who may have high Lp(a) levels.

[Xin Wang @XWang829]

Previous papers have shown that drug targets with supporting genetic evidence can have twice the success rate when reaching clinical trials. In our most recent paper (https://t.co/Rq5ZVaOwgj), we looked at how data from @23andMe can provide additional genetic evidence. 🧵1/8

[CEL @CELovegrove]

Excited to share what @drsarahhowles @DominicFurniss @mvholmes, collaborators, and I have been working on: https://t.co/yjevV8I9O5

We used systematic, regional #MendelianRandomisation & #Colocalisation to identify 3 genetic regions where #calcium, #phosphate, & #KSD colocalise.

[Pradeep Natarajan @pnatarajanmd]

10-year ASCVD risk prediction leads to older individuals being prioritized for statins missing opportunities for earlier risk recognition & prevention.
Our work led by @tigerstatdoc uses genetics & dynamic risk factor trajectories toward intersecting risk *early.* https://t.co/fmEN8Qb724 @NatureComms

[Michael V Holmes (he/him) @mvholmes]

A preprint from the 23andMe Research Team exploring the multi-ancestry genetics of diarrhea during acute Covid in which we find evidence that IBS subtypes influence risk.

Kudos to the 1st author, Ninad Chaudhary @ninaadsc, a postdoc in the Research Team!🙌https://t.co/lof1kmI43g

[Michael V Holmes (he/him) @mvholmes]

A preprint from the @23andMeResearch Team on the genetic architecture of sporadic and recurrent miscarriage and where we evaluate potential causal effects of modifiable exposures

TL;DR: we identify 11 novel GWAS loci and evidence smoking and caffeine potentially increase risk

[medRxiv @medrxivpreprint]

Trans-ancestral Genome Wide Association Study of Sporadic and Recurrent Miscarriage https://t.co/3Qvz4iYGia #medRxiv