Congratulations to Shaji, ECG-ACRIN and everyone involved - very important trial. However, since there wasn’t a clearly superior arm, the debate of RVd vs. KRD will persist. It actually opens the door for us to use either regimen based on “beliefs”.
ENURANCE Phase III trial KRd vs VRd finds no clinical benefit but added toxicity with KRd. Trial lead by @myelomaMD. Plenary presentation at #ASCO20. @eaonc@mayoclinic@vincentrk https://t.co/ATGkRl2Exm
The BCMA bispecific data are encouraging and if PFS approaches the 11-12 month mark - these OTS products would be preferred in triple class refractory. However, we still have other bispecific against others targets that may be better + hopefully we are all looking at biomarkers
Exciting results of teclistamab by @szusmani! 👍 ORR 67% in heavily pretx MM pt with long DoR even at low doses. 🙏 @myelomatom for 👍 discussion. AMG420 ORR 70%, CC93269 89% Need more data re: effectiveness of another BCMA directed tx once pt progresses through their first one.
Really promising data from DrUsmani presented at ASCO Immunotherapy special session: Teclistamab ORD 67% in those treated at 270ug - with swimmers plot showing prelim durability
Thank you to all the UVSF Nurses and nurses everywhere for doing all you do. Not a day passed that a patient doesn’t stop me to say how wonderful the nurses are!!!
1/ Covid (@UCSF) Chronicles, Day 44
Thursday, so it’s Grand Rounds day: https://t.co/Z4JMKGPC9I @YouTube. I hope you’ll watch whole 100 min: clinical updates, contact tracing, & experience in NYC. If you can spare just 35 min, watch NYC part (@ 1:04:37): fascinating & poignant.
1/ Covid (@UCSF) Chronicles, Day 38
Still stable at @UCSFHospitals & in SF. @UCSF, 15 pts, 5 on ventilators (Fig on L). In SF: 38 new cases, 23 deaths overall (up 1)(Fig R). A sad milestone: we passed 50,000 deaths in the U.S. today. Staggering, & tens of thousands more to come.
Though we don't know how many of the asymptomatic will develop symptoms this is quite a remarkable observation (obviously I am late, just a day, but in #COVID19 time, a day is like a month)